Zinc-based biomaterials for regeneration and therapy
Open accessAbstract
Zinc has been described as the 'calcium of the twenty-first century'. Zinc-based degradable biomaterials have recently emerged thanks to their intrinsic physiological relevance, biocompatibility, biodegradability, and pro-regeneration properties. Zinc-based biomaterials mainly include: metallic zinc alloys, zinc ceramic nanomaterials, and zinc metal-organic frameworks (MOFs). Metallic zinc implants degrade at a desirable rate, matching the healing pace of local tissues, and stimulating remodeling and formation of new tissues. Zinc ceramic nanomaterials are also beneficial for tissue engineering and therapy thanks to their nanostructures and antibacterial properties. MOFs have large surface areas and are easily functionalized, making them ideal for drug delivery and cancer therapy. This review highlights recent developments in zinc-based biomaterials, discusses obstacles to overcome, and pinpoints directions for future research.
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Mg-Zn alloy substrate is preferred for zinc's multifunctional bioactivity in osteogenic gene expression, signal transduction, and enzyme activation, and its intrinsic antibacterial effect, enhanced mechanical stability via Zn solid-solution strengthening, and potential benefit in degradation control.
“Here, the Mg–Zn alloy substrate is preferred for zinc's multifunctional bioactivity in osteogenic gene expression, signal transduction, and enzyme activation [15,16], as well as its intrinsic antibacterial effect [15], alongside the enhanced mechanical stability via Zn solid-solution strengthening, and potential benefit in degradation control [17].”
From Nanocatalytic magnesium osteoimplants with biodegradable self-adaptive interfaces for therapeutic repair of infected bone defects (2026) · cites this paper as [16]
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“…alloy substrate is preferred for zinc ’ s multifunctional bioactivity in osteogenic gene expression, signal transduction, and enzyme activation [15,16], as well as its intrinsic antibacterial effect [15], alongside the enhanced mechanical stability via Zn solid-solution strengthening, and…”
Self-citation
- Authors
- Su, Y., Cockerill, I., Wang, Y., Qin, Y.-X., Chang, L., Zheng, Y., & Zhu, D.
- Affiliations
- University of North Texas (US)
- Cornell University (US)
- Stony Brook University (US)
- Peking University (CN)
- Corresponding author
- Chang, Lingqian
- Zheng, Yufeng
- Zhu, Donghui
- Venue
- Trends in biotechnology
- Publisher
- Elsevier BV
- Published
- 2019-04
- Volume
- 37
- Issue
- 4
- Pages
- 428-441
- ISSN
- 0167-7799 (ISSN-L)
- PMC
- PMC6421092
- OpenAlex
- W2900857934
- Cited by
- 417
- References
- 93
- Citations by year
- 2026: 48 · 2025: 63 · 2024: 60 · 2023: 57 · 2022: 58 · 2021: 63 · 2020: 42 · 2019: 24 · 2018: 1
- FWCI
- 2.64
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in biotechnology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (R01HL140562)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Materials Science › Biomaterials › Magnesium Alloys: Properties and Applications
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- biodegradable biomaterials, zinc metal-organic frameworks, tissue regeneration, biodegradability, biocompatibility, antibacterial properties, drug delivery, cancer therapy, tissue engineering
- MeSH terms
- Biocompatible Materials, Regeneration, Trace Elements, Zinc, Regenerative Medicine
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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