Mangiferin-Loaded Polymeric Nanoparticles: Optical Characterization, Effect of Anti-topoisomerase I, and Cytotoxicity
Open accessAbstract
Mangiferin is an important xanthone compound presenting various biological activities. The objective of this study was to develop, characterize physicochemical properties, and evaluate the anti-topoisomerase activity of poly(lactic-co-glycolic acid) (PLGA) nanoparticles containing mangiferin. The nanoparticles were developed by the emulsion solvent evaporation method and the optimal formulation was obtained with a response surface methodology (RSM); this formulation showed a mean size of 176.7 ± 1.021 nm with a 0.153 polydispersibility index (PDI) value, and mangiferin encapsulation efficiency was about 55%. The optimal conditions (6000 rpm, 10 min, and 300 μg of mangiferin) obtained 77% and the highest entrapment efficiency (97%). The in vitro release profile demonstrated a gradual release of mangiferin from 15 to 180 min in acidic conditions (pH 1.5). The fingerprint showed a modification in the maximum absorption wavelength of both the polymer and the mangiferin. Results of anti-toposiomerase assay showed that the optimal formulation (MG4, 25 µg/mL) had antiproliferative activity. High concentrations (2500 µg/mL) of MG4 showed non-in vitro cytotoxic effect on BEAS 2B and HEPG2. Finally, this study showed an encapsulation process with in vitro gastric digestion resistance (1.5 h) and without interfering with the metabolism of healthy cells and their biological activity.
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Multiple delivery approaches (nanostructured lipid carriers, polymeric and chitosan-based nanogels, phospholipid complexes, targeted nanoparticles) have improved MGF exposure in preclinical systems.
“Multiple approaches have improved exposure in preclinical systems, including nanostructured lipid carriers, polymeric and chitosan-based nanogels, phospholipid complexes (2,172,173), and targeted nanoparticles designed to enhance intestinal uptake or lymphatic transport and to stabilize MGF against rapid metabolism (172,174-176).”
From Mangiferin in human disease: Multifaceted mechanisms and applications (Review) (2026) · cites this paper as [172]
The Methods and Results describe mangiferin-loaded PLGA nanoparticles with controlled release under simulated acidic gastrointestinal conditions. They do not show improved mangiferin exposure in a preclinical system or demonstrate enhanced intestinal uptake, lymphatic transport, or protection against rapid metabolism. The other delivery approaches listed in the citing sentence are not findings of this study. (LLM, conf=0.86)
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“…exposure in preclinical systems, including nanostruc‑ tured lipid carriers, polymeric and chitosan‑based nanogels, phospholipid complexes (2,172,173), and targeted nanoparticles designed to enhance intestinal uptake or lymphatic transport and to stabilize MGF against rapid metabolism…”
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Chomchoei, N., Leelapornpisid, P., Tipduangta, P., Sirithunyalug, J., Sirithunyalug, B., & Samutrtai, P. (2024) · Cosmetics · doi:10.3390/cosmetics11030093 · Cited by 3 · see citing works
A review on formulation and analytical aspect of mangiferin a natural phenolic xanthonoid
Shaikh, I., & Tatapudi, H. K. (2025) · Discover Chemistry · doi:10.1007/s44371-025-00193-0 · Cited by 3 · see citing works
Liu, C., Niu, M., Wang, Y., Ren, L., Li, Y., Jiang, N., Wu, C., Liu, N., Zhang, Y., & He, J. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5c05528 · Cited by 3 · see citing works
JAIN, R., Tiwari, R., Agrawal, O. P., & Shukla, A. K. (2023) · Asian Journal of Chemistry · doi:10.14233/ajchem.2023.28268 · Cited by 3 · see citing works
Mangiferin potentiates the activity of antifungal agents against fluconazole-resistant Candida spp.
Ferreira, T. L., Leitão, A. C., da Silva, L. J., Sá, L. G. D. A. V., Cabral, V. P. D. F., Rodrigues, D. S., Barbosa, S. A., Neto, J. B. D. A., Barbosa, A. D., Moreira, L. E. A., et al. (2024) · Future Microbiology · doi:10.1080/17460913.2024.2366627 · Cited by 2 · see citing works
Camacho-González, C. E., Cardona-Félix, C. S., Larios, A. P., Sáyago‐Ayerdi, S. G., Zamora-Gasga, V. M., López‐García, U. M., & Sánchez-Burgos, J. A. (2025) · Reactive and Functional Polymers · doi:10.1016/j.reactfunctpolym.2025.106386 · Cited by 2 · see citing works
Self-citationRazura-Carmona, F. F., Herrera-Martínez, M., Sánchez-Burgos, J. A., Larios, A. P., Díaz‐Reséndiz, K. J. G., Girón‐Pérez, M. I., & Ramı́rez-Mares, M. V. (2025) · Toxicology in Vitro · doi:10.1016/j.tiv.2025.106107 · Cited by 2 · see citing works
Self-citationPolymeric matrices for mangiferin delivery: Ways to enhance bioavailability and therapeutic effect
Shaikenov, R. O., Klimshina, V. I., Morozkina, S. N., & Snetkov, P. P. (2025) · The 5th International Electronic Conference on Applied Sciences · doi:10.3390/engproc2025087078 · Cited by 2 · see citing works
Vu, T. H. N., Morozkina, S. N., Ситникова, В. Е., Generalova, Y. E., Nguyễn, Q. S., & Uspenskaya, M. V. (2026) · Polymer Bulletin · doi:10.1007/s00289-026-06500-8 · Cited by 1 · see citing works
Camacho-González, C. E., Larios, A. P., Sáyago‐Ayerdi, S. G., Salazar-Mendoza, J., & Sánchez-Burgos, J. A. (2024) · Separations · doi:10.3390/separations11090263
Self-citationPreparation, Characterization and Quantification of Mangiferin in Mangiferin-loaded Microspheres
Yadav, S., & Harwansh, R. K. (2024) · Current Pharmaceutical Analysis · doi:10.2174/0115734129333656240905080754
Camacho-González, C. E., Larios, A. P., Cardona-Félix, C. S., Sáyago‐Ayerdi, S. G., Zamora-Gasga, V. M., López‐García, U. M., & Sánchez-Burgos, J. A. (2025) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2025.114536
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RetractedMiramontes-Escobar, H. A., Pulido-Guevara, M. A., Zárate, P. A., Michel, M. R. M., Zamora-Gasga, V. M., & Sánchez-Burgos, J. A. (2026) · ACS Food Science & Technology · doi:10.1021/acsfoodscitech.6c00557
Self-citation
- Authors
- Razura-Carmona, F. F., Pérez-Larios, A., González-Silva, N., Herrera-Martínez, M., Medina-Torres, L., Sáyago-Ayerdi, S. G., & Sánchez-Burgos, J. A.
- Affiliations
- Tecnológico Nacional de México/I.T. Tepic, Laboratorio Integran de Investigación en Alimentos, Lagos del Country, Tepic CP 63175, Nayarit, Mexico
- Division of Agricultural Sciences and Engineering, University Center of the Altos, University of Guadalajara, Tepatitlán de Morelos CP 47620, Jalisco, Mexico
- Universidad de la Cañada (MX)
- Facultad de Química, Universidad Nacional Autónoma de México, México D.F. CP 04510, Mexico
- Tecnológico Nacional de México (MX)
- Corresponding author
- Sánchez-Burgos, Jorge Alberto
- ORCID
- Venue
- Cancers
- Publisher
- MDPI AG
- Published
- 2019-12-06
- Volume
- 11
- Issue
- 12
- Pages
- 1965
- ISSN
- 2072-6694 (ISSN-L)
- PMC
- PMC6966478
- OpenAlex
- W2994331481
- Cited by
- 40
- References
- 59
- Citations by year
- 2026: 2 · 2025: 11 · 2024: 9 · 2023: 8 · 2022: 5 · 2021: 4 · 2020: 1
- FWCI
- 0.71
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Cancers (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Universidad de Guadalajara
- Consejo Nacional de Ciencia y Tecnología (787023)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Health Sciences › Medicine › Complementary and alternative medicine › Mangiferin and Mango Extracts
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- mangiferin, PLGA nanoparticles, polymeric nanoparticles, xanthones, topoisomerase I inhibition, anticancer activity, encapsulation efficiency, in vitro drug release, cytotoxicity, BEAS-2B, HepG2 cells, emulsion solvent evaporation, response surface methodology
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