Soya phospholipid complex of mangiferin enhances its hepatoprotectivity by improving its bioavailability and pharmacokinetics
Abstract
Background Mangiferin is a xanthonoid present in Mangifera indica. It has been reported for a variety of pharmacological activities, including hepatoprotection. However, the major disadvantage of mangiferin is its reduced biological activity due to poor absorption, low bioavailability and rapid elimination from the body after administration. The aim of this study was to prepare a phospholipid complex of mangiferin to overcome these limitations and to investigate the impact of the complex on hepatoprotective activity and bioavailability. Results The results showed that the complex has an enhanced hepatoprotective and in vivo antioxidant activity as compared to pure mangiferin at the same dose level (30 and 60 mg kg⁻¹). The complex restored the levels of serum hepatic marker enzymes and liver antioxidant enzymes with respect to carbon tetrachloride-treated animals. The complex also increased the bioavailability of mangiferin in rat serum by 9.75-fold compared to pure mangiferin at the same dose level and enhanced the elimination half-life (t(1/2 el)) from 1.71 ± 0.12 h⁻¹ to 3.52 ± 0.27 h⁻¹. Conclusion The results suggested that the complexation of mangiferin with soya phospholipid enhanced the hepatoprotection and in vivo antioxidant activity, which may be due to the improved bioavailability and pharmacokinetics of mangiferin in rat serum.
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MGF has low water solubility (0.111 mg/ml) and poor oral bioavailability (~1.2%) due to limited lipophilicity and intestinal permeability.
“Despite its low water solubility (0.111 mg/ml) (1) and poor oral bioavailability (~1.2%) (2,3), due to its limited lipophilicity and intestinal permeability (4), MGF has been identified in 96 species, 28 genera and 19 families of angiosperms (5).”
From Mangiferin in human disease: Multifaceted mechanisms and applications (Review) (2026) · cites this paper as [2]
Multiple delivery approaches (nanostructured lipid carriers, polymeric and chitosan-based nanogels, phospholipid complexes, targeted nanoparticles) have improved MGF exposure in preclinical systems.
“Multiple approaches have improved exposure in preclinical systems, including nanostructured lipid carriers, polymeric and chitosan-based nanogels, phospholipid complexes (2,172,173), and targeted nanoparticles designed to enhance intestinal uptake or lymphatic transport and to stabilize MGF against rapid metabolism (172,174-176).”
From Mangiferin in human disease: Multifaceted mechanisms and applications (Review) (2026) · cites this paper as [2]
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- Authors
- Bhattacharyya, S., Ahmmed, S. M., Saha, B. P., & Mukherjee, P. K.
- Affiliations
- Jadavpur University (IN)
- Corresponding author
- Mukherjee, Pulok K
- Venue
- Journal of the Science of Food and Agriculture
- Publisher
- Wiley
- Published
- 2013-10-31
- Volume
- 94
- Issue
- 7
- Pages
- 1380-1388
- ISSN
- 0022-5142 (ISSN-L)
- 1097-0010
- OpenAlex
- W2164221544
- Cited by
- 56
- References
- 38
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 8 · 2023: 4 · 2022: 7 · 2021: 5 · 2020: 6 · 2019: 3 · 2018: 2 · 2017: 3 · 2016: 4 · 2015: 2 · 2014: 1 · 2013: 1
- FWCI
- 6.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the Science of Food and Agriculture (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Mangiferin and Mango Extracts
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pineapple and bromelain studies
- Keywords
- mangiferin, hepatoprotection, bioavailability, pharmacokinetics, antioxidant activity, carbon tetrachloride-induced liver injury, elimination half-life, mango, drug delivery
- MeSH terms
- Animals, Antioxidants, Carbon Tetrachloride Poisoning, Dietary Fats, Half-Life, Kinetics, Liver, Male, Nutritive Value, Particle Size, Phospholipids, Seeds, Glycine max, Biomarkers, Rats, Wistar, Oxidative Stress, Dietary Supplements, Protective Agents, Xanthones, Hepatic Insufficiency
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