The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Vitamins E plus C and interacting conutrients required for optimal health
Abstract
Antioxidants are crucial components of fruit/vegetable‐rich diets preventing cardiovascular disease (CVD) and cancer: —plasma vitamins C, E, carotenoids from diet correlate prevalence of CVD and cancer inversely, low levels predict an increased risk of individuals which is potentiated by combined inadequacy (e.g., vitamins C+E, C+carotene, A+carotene); —self‐prescribed rectification of vitamins C and E at adequacy of other micronutrients reduce forthcoming CVD, of vitamins A, C, E, carotene and conutrients also cancer; —randomized exclusive supplementation of β‐carotene±vitamin A or E lack benefits except prostate cancer reduction by vitamin E, and overall cancer reduction by selenium; —randomized intervention with synchronous rectification of vitamins A+C+E+B+minerals reduces CVD and counteracts precancerous lesions; —high vitamin E supplements reveal potentials in secondary CVD prevention. Plasma values desirable for primary prevention: ≥30μmol/l lipid‐standardized vitamin E (α‐tocopherol/cholesterol ≥5.0μmol/mmol); ≥50μmol/l vitamin C aiming at vitamin C/vitamin E ratio >1.3–1.5; ≥0.4μmol/l β‐ (≥0.5μmol/l α+β‐) carotene. Conclusions: —in CVD vitamin E acts as first risk discriminator, vitamin C as second one; —optimal health requires synchronously optimized vitamins C+E, A, carotenoids and vegetable conutrients.
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Cites
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Sick individuals and sick populations
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Cited by
PlantL-ascorbic acid: chemistry, function, metabolism, bioavailability and effects of processing
Davey, M. W., Montagu, M. V., Inz�, D., Sanmartin, M., Kanellis, A., Smirnoff, N., Benzie, I. J., Strain, J. J., Favell, D., & Fletcher, J. (2000) · Journal of the Science of Food and Agriculture · doi:10.1002/(sici)1097-0010(20000515)80:7<825::aid-jsfa598>3.0.co;2-6 · Cited by 1,427
Ascorbic acid: Chemistry, biology and the treatment of cancer
Du, J., Cullen, J. J., & Buettner, G. R. (2012) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2012.06.003 · Cited by 1,070
New hypotheses for the health-protective mechanisms of whole-grain cereals: what is beyond fibre?
Fardet, A. (2010) · Nutrition Research Reviews · doi:10.1017/s0954422410000041 · Cited by 1,030
Carr, A. C., & Frei, B. (1999) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/69.6.1086 · Cited by 940
Vitamin E: non-antioxidant roles
Azzi, A., & Stocker, A. (2000) · Progress in Lipid Research · doi:10.1016/s0163-7827(00)00006-0 · Cited by 488
Metadata
- Authors
- Fred Gey, K.
- Venue
- BioFactors
- Publisher
- Wiley
- Published
- 1998-01
- Volume
- 7
- Issue
- 1-2
- Pages
- 113-174
- ISSN
- 0951-6433 (ISSN-L)
- 1872-8081
- OpenAlex
- W2074039575
- Cited by
- 240
- References
- 22
- FWCI
- 9.50
- Type
- journal article
- Language
- en
- Open access
- closed
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