Nutritional factors in inflammatory bowel disease
Abstract
Dietary antigens may act as important stimuli of the mucosal immune system and have led to the study of nutritional therapy for IBD. Patients with active CD respond to bowel rest, along with total enteral nutrition or TPN. Bowel rest and TPN are as effective as corticosteroids at inducing remission for patients with active CD, although benefits are short-lived. Enteral nutrition is consistently less effective than conventional corticosteroids for treatment of active CD. Use of palatable, liquid polymeric diets in active CD is controversial, but these diets are of equal efficacy when compared with elemental diets. UC has not been treated effectively with either elemental diets or TPN. Fish oil contains n-3-PUFA, which inhibits production of proinflammatory cytokines and has some benefit in the treatment of CD. Topical applications of short-chain fatty acids have benefited diversion colitis and distal UC, whereas probiotics hold promise in the treatment of pouchitis.
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Dietary antigens can stimulate the mucosal immune system, so bowel rest with total parenteral nutrition has been used to treat some IBD patients.
“Because dietary antigens can stimulate the mucosal immune system, bowel rest with total parenteral nutrition (TPN) has been used to treat certain patients with IBD72.”
From Diet and the Intestinal Microbiome: Associations, Functions, and Implications for Health and Disease (2014) · cites this paper as [72]
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- Authors
- Graham, T. O., & Kandil, H. M.
- Affiliations
- University of Pittsburgh Medical Center (US)
- Venue
- Gastroenterology Clinics of North America
- Publisher
- Elsevier BV
- Published
- 2002-03
- Volume
- 31
- Issue
- 1
- Pages
- 203-218
- ISSN
- 0889-8553 (ISSN-L)
- OpenAlex
- W2149240884
- Cited by
- 30
- References
- 133
- Citations by year
- 2021: 2 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 2 · 2014: 3 · 2012: 2
- FWCI
- 0.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gastroenterology Clinics of North America (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Keywords
- inflammatory bowel disease, Crohn's disease, ulcerative colitis, nutritional therapy, dietary antigens, mucosal immunity, total parenteral nutrition, enteral nutrition, bowel rest, corticosteroids, remission induction, elemental diet, polymeric diet, fish oil, omega-3 fatty acids, short-chain fatty acids, topical application, probiotics, pouchitis, diversion colitis
- MeSH terms
- Diet, Humans, Nutrition Disorders, Inflammatory Bowel Diseases
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