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Examining the Cultivation, Degradation Characteristics and Health Effects of the Golden Oyster Mushroom Pleurotus citrinopileatus (Agaricomycetes): A Review

Tao, Z., & Zheng, Q. (2023) · International journal of medicinal mushrooms · doi:10.1615/intjmedmushrooms.2023047581 · Cited by 10 · see citing works

A novel antioxidant ergothioneine PET radioligand for in vivo imaging applications

Behof, W. J., Whitmore, C. A., Haynes, J. R., Rosenberg, A. J., Tantawy, M. N., Peterson, T. E., Harrison, F. E., Beelman, R. B., & Pham, W. N. (2021) · Scientific Reports · doi:10.1038/s41598-021-97925-w · Cited by 10 · see citing works

Systematic metabolic characterization of mental disorders reveals age‐related metabolic disturbances as potential risk factors for depression in older adults

Liu, Y., Zhao, W., Lu, Y., Zhao, Y., Zhang, Y., Dai, M., Hai, S., Ge, N., Zhang, S., Huang, M., et al. (2022) · MedComm · doi:10.1002/mco2.165 · Cited by 9 · see citing works

Ganoderma Fusions with High Yield of Ergothioneine and Comparative Analysis of Its Genomics

Xie, J., Yu, Y., You, J., Ye, Z., Zhou, F., Wang, N., Zhong, J., Guo, L., & Lin, J. (2023) · Journal of Fungi · doi:10.3390/jof9111072 · Cited by 9 · see citing works

Enhanced production of ergothioneine in Aspergillus oryzae

Wang, L., Tian, X., Xue, P., Deng, Y., Gao, R., & Hu, Z. (2025) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-025-13505-2 · Cited by 9 · see citing works

Improved synthesis of an ergothioneine PET radioligand for imaging oxidative stress in Alzheimer’s disease

Behof, W. J., Whitmore, C. A., Haynes, J. R., Rosenberg, A. J., Tantawy, M. N., Peterson, T. E., Harrison, F. E., Beelman, R. B., Wijesinghe, P., Matsubara, J. A., et al. (2022) · FEBS Letters · doi:10.1002/1873-3468.14303 · Cited by 9 · see citing works

Effects of Consuming White Button and Oyster Mushrooms within a Healthy Mediterranean-Style Dietary Pattern on Changes in Subjective Indexes of Brain Health or Cognitive Function in Healthy Middle-Aged and Older Adults

Uffelman, C. N., Harold, R., Hodson, E. S., Chan, N. I., Foti, D., & Campbell, W. W. (2024) · Foods · doi:10.3390/foods13152319 · Cited by 8 · see citing works

Golden Oyster Mushroom Extract Ameliorates Oxidative Stress-Induced Cell Death in Neurons and Scopolamine-Induced Cholinergic System Impairment in Mice

Ryu, H.-S., Sanjay, S., Choi, S.-K., Lee, K.-H., Jang, S.-S., Yang, S.-Y., Kwon, Y.-S., Ku, S., & Lee, H. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05223-7 · Cited by 8 · see citing works

Construction of a genetic linkage map and detection of quantitative trait locus for the ergothioneine content in tamogitake mushroom (Pleurotus cornucopiae var. citrinopileatus)

Yoneyama, S., Maeda, K., Sadamori, A., Saitoh, S., Tsuda, M., Azuma, T., Nagano, A. J., Tomiyama, T., & Matsumoto, T. (2021) · Mycoscience · doi:10.47371/mycosci.2020.11.003 · Cited by 8 · see citing works

Aminothioneine, a product derived from golden oyster mushrooms (Pleurotus cornucopiae var. citrinopileatus), activates Ca2+ signal-mediated brain-derived neurotrophic factor expression in cultured cortical neurons

Fukuchi, M., Watanabe, K., Mitazaki, S., Fukuda, M., & Matsumoto, S. (2021) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2021.101185 · Cited by 8 · see citing works

L -Ergothioneine ameliorates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson’s disease in C57BL/6J mice by activating DJ-1

Meng, X., Meng, H., Hou, S., Yin, Z., Wang, X., Gong, K., Zhang, F., Li, Q., Zhang, S., Chen, Y., et al. (2024) · Food Science and Human Wellness · doi:10.26599/fshw.2024.9250068 · Cited by 7 · see citing works

Ergothioneine: A Multifunctional Dietary Antioxidant with Emerging Therapeutic Potential

Chen, K., Chen, X., He, W., Deng, W., Wu, M., Li, H., Shen, Y., & Zhang, L. (2025) · Food Reviews International · doi:10.1080/87559129.2025.2513568 · Cited by 7 · see citing works

Novel fava bean 11S nanofiber gels for sustained ergothioneine delivery: a calcium ion and κ-carrageenan approach

Chen, H., Zhou, M., Xu, Z., Dong, X., Ding, X., Zhou, X., & Cui, P. (2025) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2025.111604 · Cited by 7 · see citing works

Ergothioneine boosts mitochondrial respiration and exercise performance via direct activation of MPSTPreprint

Sprenger, H., Mittenbühler, M. J., Sun, Y., Vranken, J. G. V., Schindler, S., Jayaraj, A., Khetarpal, S. A., Vargas‐Castillo, A., Puszynska, A. M., Spinelli, J. B., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.04.10.588849 · Cited by 7 · see citing works

HIV and the Antiviral Role of Mushroom Nutraceuticals

Fernandes, T. H., Chaquisse, E., & Ferrão, J. (2020) · European journal of applied sciences · doi:10.14738/aivp.83.8650 · Cited by 6 · see citing works

Determination of L-ergothioneine in food by UPLC-MS/MS method

Zhai, H., Sun, L., Fan, S., Wang, J., Cao, M., Ma, H., Li, Q., & Zhang, Y. (2023) · Journal of Future Foods · doi:10.1016/j.jfutfo.2022.12.007 · Cited by 6 · see citing works

Ergothioneine alleviates osteoporosis via the ROS-MAPK signaling Axis

Guo, Z., Huang, Y., Wang, X., Han, Y., Li, A., Qu, Y., Chen, L., Du, M., Zhang, Y., & Xu, Y. (2025) · Bone · doi:10.1016/j.bone.2025.117496 · Cited by 5 · see citing works

Engineering Kluyveromyces lactis for de novo production of ergothioneine

Chen, Z., Guo, K., Liu, H., & Qiu, Y. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.106963 · Cited by 5 · see citing works

Scalable ergothioneine production via integrating chemical methylation and rhodanese-catalyzed CS bond formation

Lü, J., Sun, X., Weng, H., Ding, W., Yang, F., Du, G., Xu, R., & Kang, Z. (2026) · Chemical Engineering Journal · doi:10.1016/j.cej.2026.172593 · Cited by 5 · see citing works

The Association Between Serum Ergothioneine Concentration and Japanese Dietary Habits: The Third Survey of the ROAD Study

Suzuki, K., Kaneda, Y., Izumo, T., Nakao, Y., Iidaka, T., Horii, C., Muraki, S., Oka, H., Kawaguchi, H., Akune, T., et al. (2025) · Nutrients · doi:10.3390/nu17030517 · Cited by 5 · see citing works

The Role of Antioxidant on Health and Age-Related Diseases in Aging

Tan, B. L., & Norhaizan, M. E. (2021) · Springer eBooks · doi:10.1007/978-3-030-82859-2_7 · Cited by 5 · see citing works

L-ergothioneine; a potential adjuvant in the management of diabetic nephropathy

Dare, A., Channa, M. L., & Nadar, A. (2021) · Pharmacological Research - Modern Chinese Medicine · doi:10.1016/j.prmcm.2021.100033 · Cited by 5 · see citing works

Effects of ergothioneine on oxidative DNA damage and immune response induced by circadian rhythm disturbance in mice

Li, Y., Fujihara, H., Fujisawa, K., & Kawai, K. (2024) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.24-220 · Cited by 4 · see citing works

A review on therapeutic potential of wild mushrooms with their relative status in Chhattisgarh, Central India

Verma, S., Tirkey, S., & Shukla, K. K. (2023) · Oriental Pharmacy and Experimental Medicine · doi:10.1007/s13596-023-00713-2 · Cited by 4 · see citing works

The Potentials of Ergothioneine in the management of diseases in animals

Adah, A. S. (2023) · Media Kedokteran Hewan · doi:10.20473/mkh.v34i1.2023.36-52 · Cited by 4 · see citing works

Ergothioneine as a potential geroprotector: Targeting molecular hallmarks of ageing and age-related diseases

Zhao, P., & Qi, Y. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103158 · Cited by 3 · see citing works

Edible Mushrooms as Neuro-nutraceuticals: Basis of Therapeutics

Remya, V. R., Chandra, G., & Mohanakumar, K. P. (2019) · Springer eBooks · doi:10.1007/978-981-13-6382-5_2 · Cited by 3 · see citing works

Possible Treatment of Neuropsychiatric Disorders by Promotion of Neuronal Differentiation through Organic Cation Transporters

Nakamichi, N., Masuo, Y., & Kato, Y. (2019) · YAKUGAKU ZASSHI · doi:10.1248/yakushi.18-00173-1 · Cited by 3 · see citing works

A scoping review of the effects of mushroom and fungus extracts in rodent models of depression and tests of antidepressant activity

Wang, C. K., Kim, G., Aleksandrova, L. R., Panenka, W. J., & Barr, A. M. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1387158 · Cited by 3 · see citing works

Exploring the causal association between serum metabolites and erectile dysfunction: a bidirectional Mendelian randomisation study

Xu, R., Liu, S., Li, L., Bu, Y., Bai, P., Luo, G., & Wang, X. (2024) · International Journal of Impotence Research · doi:10.1038/s41443-024-00926-2 · Cited by 4 · see citing works

Functional Expression of Carnitine/Organic Cation Transporter 1 in Murine Choroid Plexus

Ishimoto, T., Nakamichi, N., Taguchi, T., Nishiyama, M., & Kato, Y. (2024) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b24-00451 · Cited by 2 · see citing works

Protective Effects of Pleurotus Species on UVB-Induced Skin Disorders at Clinically Relevant Plasma Concentrations of the Antioxidant Ergothioneine in Hairless Mice

Hanayama, M., Ishimoto, T., Moritomo, A., Yamashita, R., Kawai, J., Mori, K., & Kato, Y. (2025) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b24-00893 · Cited by 2 · see citing works

Neuronal differentiation of human dental pulp stem cells induced by co-treatment of ergothioneine

Thongsuk, A., Seemaung, P., Phanthong, P., Janebodin, K., Ruangsawasdi, N., Gonmanee, T., Phruksaniyom, C., Chodchavanchai, T., Balit, T., White, K. L., et al. (2025) · PLoS ONE · doi:10.1371/journal.pone.0331120 · Cited by 2 · see citing works

Multifunctional Roles and Microbial Production Bottlenecks of Ergothioneine

Ma, Z., Qin, C., Deng, Y., Guo, X., Zhu, L., Zhu, D., & Chen, X. (2026) · ACS Synthetic Biology · doi:10.1021/acssynbio.5c00735 · Cited by 2 · see citing works

Trideoxycytidine Diphosphate Promotes Neural Stem Cell Proliferation and Neurogenesis in Mice

Ishimoto, T., Hayashi, F., Yamamoto, Y., Kiriyama, K., Yamashita, R., Matsumura, N., Nishiuchi, T., Masuo, Y., Fujita, M., Sutoh, K., et al. (2024) · Journal of Nutrition · doi:10.1016/j.tjnut.2024.12.021 · Cited by 1 · see citing works

Profiling the metabolome of older adults who live with overweight/obesity and undiagnosed cognitive impairment

Alvarez, K. L. F., Ortiz-Manrique, M. M., Dávila-Del-Carpio, G., Peralta-Mestas, A., & Cardenas, C. L. L. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.07.037 · Cited by 1 · see citing works

Ergothioneine promotes osteogenesis and angiogenesis through PI3K/AKT pathway and prevents glucocorticoid-induced osteonecrosis of the femoral head

Xuecheng, S., Gaoxin, J., Hang, L., & Xinlong, M. (2026) · Scientific Reports · doi:10.1038/s41598-026-38834-8 · Cited by 1 · see citing works

Ergothioneine as an emerging food-derived bioactive compound protecting against age-related diseases: issues needing more research

Halliwell, B. B. (2026) · American Journal of Clinical Nutrition · doi:10.1016/j.ajcnut.2026.101488 · Cited by 1 · see citing works

Ergothioneine, collagen peptides, and sodium hyaluronate ameliorate facial skin aging via modulating oxidative stress, inflammation, and extracellular matrix homeostasis

Zhou, Z., Zhao, L., Chen, L., Zhao, X., Xinwei, L., Luo, X., Zhang, B., Miao, J., & Liu, F. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1888269 · Cited by 1 · see citing works

Ergothioneine: An integrated perspective from biosynthetic strategies to health-promoting applications

Liu, M., & 罗云波 (2026) · Food Bioscience · doi:10.1016/j.fbio.2026.109875 · Cited by 1 · see citing works

Mushrooms: A Wealth of Resource for Prospective Stem Cell-Based Therapies

Shibu, M. A., Tamilselvi, S., Agrawal, D. C., & Huang, C. (2019) · Springer eBooks · doi:10.1007/978-981-13-6382-5_6 · Cited by 1 · see citing works

Regulation of Neurogenesis by Organic Cation Transporters: Potential Therapeutic Implications

Ishimoto, T., & Kato, Y. (2021) · Handbook of experimental pharmacology · doi:10.1007/164_2021_445 · Cited by 1 · see citing works

Comment on “Mushroom intake and depression: A population-based study using data from the US National Health and Nutrition Examination Survey (NHANES), 2005–2016”

Rzymski, P. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.09.008 · Cited by 1 · see citing works

Process Development of Ergothioneine by Submerged Fermentation of a Novel Medicinal Mushroom Panus ConchatusPreprint

Zhu, M., Han, Y., Hu, X., & Ren, L. (2021) · Research Square · doi:10.21203/rs.3.rs-1081981/v1

Sulfur-Containing Compounds from Fungi

Garcia, J., Silva, J., Gouvinhas, I., Guimarães, R., Bovolini, A., Saavedra, M. J., & Alves, M. J. (2023) · Springer eBooks · doi:10.1007/978-3-031-18587-8_20

Modulatory effects of ergothioneine on behavioural responses of Arabian stallions following a 2,000 m race during the rainy and hot-dry seasons in a tropical environment

Adah, A. S., Ayo, J. O., REKWOT, P. I., Aluwong, T., & Adah, D. A. (2023) · Open Veterinary Science · doi:10.1515/ovs-2022-0119

A randomised controlled study to investigate the cognitive, mood, metabolic and anti-inflammatory effects of acute oyster mushroom intervention in healthy older adults.

Cha, S., Bell, L., Fisher, D. R., Shukitt-Hale, B., Zhang, Z.-C., Rodriguez-Mateos, A., & Williams, C. M. (2025) · Food & Function · doi:10.1039/d5fo03075g

Additional file 1 of Toward more efficient ergothioneine production using the fungal ergothioneine biosynthetic pathway

Chen, Z., He, Y., Wu, X., Wang, L., Dong, Z., & Chen, X. (2022) · Figshare · doi:10.6084/m9.figshare.19728307

Medicinal Mushrooms and Mental Disorders: How Mushrooms Affect Anxiety and Depression

Tarki, A., Hajikarim‐Hamedani, A., Rassa, S., & Khosravi, S. (2025) · Nutritional neurosciences · doi:10.1007/978-981-95-2774-8_6

Ergothioneine in the brain

Ishimoto, T., & Kato, Y. (2022) · FEBS Letters · doi:10.1002/1873-3468.14271 · Cited by 55 · see citing works

Oral administration of food-derived hydrophilic antioxidant ergothioneine enhances object recognition memory and promotes neuronal maturation in murine hippocampus

Nakao, S., Nakamichi, N., Masuo, Y., Takeda, Y., Matsumoto, S., Suzuki, M., & Kato, Y. (2019) · Proceedings for Annual Meeting of The Japanese Pharmacological Society · doi:10.1254/jpssuppl.92.0_2-yia-03

PS204. Food-derived antidepressant-like compound ergothioneine promotes neuronal differentiation via activating mTORC1 and neurotrophic factor signaling in neural stem cells.

Ishimoto, T., Kato, Y., Masuo, Y., & Nakamichi, N. (2016) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyw043.204

Oral Administration of the Food-Derived Hydrophilic Antioxidant Ergothioneine Enhances Object Recognition Memory in Mice

Nakamichi, N., Nakao, S., Nishiyama, M., Takeda, Y., Ishimoto, T., Masuo, Y., Matsumoto, S., Suzuki, M., & Kato, Y. (2020) · Current Molecular Pharmacology · doi:10.2174/1874467213666200212102710 · Cited by 50 · see citing works

Longitudinal Consumption of Ergothioneine Reduces Oxidative Stress and Amyloid Plaques and Restores Glucose Metabolism in the 5XFAD Mouse Model of Alzheimer’s Disease

Whitmore, C. A., Haynes, J. R., Behof, W. J., Rosenberg, A. J., Tantawy, M. N., Hachey, B. C., Wadzinski, B. E., Spiller, B. W., Peterson, T. E., Paffenroth, K. C., et al. (2022) · Pharmaceuticals · doi:10.3390/ph15060742 · Cited by 50 · see citing works