In vivo antioxidant status: A putative target of antidepressant action

Zafir, Ayesha; Ara, Anjum; Banu, Naheed

doi:10.1016/j.pnpbp.2008.11.010

Cited by 183Treatment of Major DepressionAntioxidant Activity and Oxidative StressTryptophan and brain disorders

In vivo antioxidant status: A putative target of antidepressant action

Zafir, Ayesha, Ara, Anjum, Banu, Naheed·2009·Progress in Neuro-Psychopharmacology and Biological Psychiatry

DOI 10.1016/j.pnpbp.2008.11.010

Open this paper in CoChat — free account

Abstract

Oxidative stress is a critical route of damage in various psychological stress-induced disorders, such as depression. Antidepressants are widely prescribed to treat these conditions; however, few animal studies have investigated the effect of these drugs on endogenous antioxidant status in the brain. The present study employed a 21-day chronic regimen of random exposure to restraint stress to induce oxidative stress in brain, and behavioural aberrations, in rodents. The forced swimming (FST) and sucrose preference tests were used to identify depression-like phenotypes, and reversal in these indices indicated the effectiveness of treatment with fluoxetine (FLU; 20 mg/kg/day, p.o.; selective serotonin reuptake inhibitor), imipramine (IMI; 10 mg/kg/day, p.o.; tricyclic antidepressant) and venlafaxine (VEN; 10 mg/kg/day, p.o.; dual serotonin/norepinephrine reuptake inhibitor) following restraint stress. The antioxidant status was investigated in the brain of these animals. The results evidenced a significant recovery in the activities of superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST), glutathione reductase (GR) and glutathione (GSH) levels by antidepressant treatments following a restraint stress-induced decline of these parameters. The severely accumulated lipid peroxidation product malondialdehyde (MDA) and protein carbonyl contents in stressed animals were significantly normalized by antidepressant treatments. The altered oxidative status is implicated in various aspects of cellular function affecting the brain. Thus, it is possible that augmentation of in vivo antioxidant defenses could serve as a convergence point for multiple classes of antidepressants as an important mechanism underlying the neuroprotective pharmacological effects of these drugs observed clinically in the treatment of various stress disorders. Consequently, pharmacological modulation of stress-induced oxidative damage as a possible stress-management approach should be an important avenue of further research.

Integrity signals

Registry

Crossref · 10.1016/j.pnpbp.2008.11.010

Cites

84 of 84 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Fluoxetine and venlafaxine treatment prevents lipid and protein oxidative damage induced by stress.
“Also, fluoxetine and venlafaxine treatment prevented lipid and protein oxidative damage induced by stress [24].”
From Preclinical and Clinical Evidence of Antioxidant Effects of Antidepressant Agents: Implications for the Pathophysiology of Major Depressive Disorder (2012) · cites this paper as [24]
Fluoxetine and venlafaxine produce significant recovery in activities of SOD, CAT, GST, GR, and GSH levels after restraint stress in rat brain.
“The results evidenced a significant recovery in the activities of SOD, CAT, GST, GR, and GSH levels by these antidepressants after restraint stress.”
From Preclinical and Clinical Evidence of Antioxidant Effects of Antidepressant Agents: Implications for the Pathophysiology of Major Depressive Disorder (2012) · cites this paper as [24]

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 315,771 · see citing works
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works
[13] Catalase in vitro
Aebi, H. (1984) · Methods in Enzymology · doi:10.1016/s0076-6879(84)05016-3 · Cited by 25,696 · see citing works
Diagnostic and Statistical Manual of Mental Disorders
(2012) · Springer eBooks · doi:10.1007/springerreference_121117 · Cited by 20,769 · see citing works
Glutathione S-Transferases
Habig, W. H., Pabst, M. J., & Jakoby, W. B. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)42083-8 · Cited by 18,396 · see citing works
[30] Microsomal lipid peroxidation
Buege, J. A., & Aust, S. D. (1978) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(78)52032-6 · Cited by 13,437 · see citing works
Involvement of the Superoxide Anion Radical in the Autoxidation of Pyrogallol and a Convenient Assay for Superoxide Dismutase
Marklund, S. L., & MARKLUND, G. (1974) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1974.tb03714.x · Cited by 10,382 · see citing works
How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions
Sapolsky, R. M., Romero, L. M., & Munck, A. U. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.1.0389 · Cited by 7,541 · see citing works
How Do Glucocorticoids Influence Stress Responses? Integrating Permissive, Suppressive, Stimulatory, and Preparative Actions
Sapolsky, R. M. (2000) · Endocrine Reviews · doi:10.1210/er.21.1.55 · Cited by 7,533 · see citing works
[49] Determination of carbonyl content in oxidatively modified proteins
Levine, R. L., Garland, D. L., Oliver, C. N., Amici, A., Climent, I., Lenz, A.-G., Ahn, B. W., Shaltiel, S., & Stadtman, E. R. (1990) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(90)86141-h · Cited by 5,895 · see citing works
Stress and the brain: from adaptation to disease
de Kloet, E. R., Joëls, M., & Holsboer, F. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1683 · Cited by 4,621 · see citing works
Depression: a new animal model sensitive to antidepressant treatments
PORSOLT, R. D., LE PICHON, M., & JALFRE, M. (1977) · Nature · doi:10.1038/266730a0 · Cited by 4,451 · see citing works
Bromobenzene-Induced Liver Necrosis. Protective Role of Glutathione and Evidence for 3,4-Bromobenzene Oxide as the Hepatotoxic Metabolite
Jollow, D. J., Mitchell, J. R., ZAMPAGLIONE, N. G., & Gillette, J. R. (2008) · Pharmacology · doi:10.1159/000136485 · Cited by 3,291 · see citing works
Behavioural despair in rats: A new model sensitive to antidepressant treatments
Porsolt, R. D., Anton, G., Blavet, N., & Jalfre, M. (1978) · European Journal of Pharmacology · doi:10.1016/0014-2999(78)90118-8 · Cited by 3,138 · see citing works
Subgenual prefrontal cortex abnormalities in mood disorders
Drevets, W. C., Price, J. L., Simpson, J. R., Todd, R. D., Reich, T., Vannier, M., & Raichle, M. E. (1997) · Nature · doi:10.1038/386824a0 · Cited by 2,693 · see citing works
Protein carbonyl groups as biomarkers of oxidative stress
Dalle‐Donne, I., Rossi, R., Giustarini, D., Milzani, A., & Colombo, R. (2003) · Clinica Chimica Acta · doi:10.1016/s0009-8981(03)00003-2 · Cited by 2,352 · see citing works
Purification and characterization of the flavoenzyme glutathione reductase from rat liver.
Carlberg, I., & Mannervik, B. (1975) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)41206-4 · Cited by 2,024 · see citing works
Hippocampal atrophy in recurrent major depression
Sheline, Y. I., Wang, P. W., Gado, M. H., Csernansky, J. G., & Vannier, M. W. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.9.3908 · Cited by 1,932 · see citing works
The proto-oncogene Bcl-2 and its role in regulating apoptosis
Kroemer, G. (1997) · Nature Medicine · doi:10.1038/nm0697-614 · Cited by 1,739 · see citing works
Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species
Kane, D. J., Sarafian, T. A., Anton, R., Hahn, H., Gralla, E. B., Valentine, J. S., Örd, T., & Bredesen, D. E. (1993) · Science · doi:10.1126/science.8235659 · Cited by 1,671 · see citing works
Chronic Mild Stress (CMS) Revisited: Consistency and Behavioural-Neurobiological Concordance in the Effects of CMS
Willner, P. (2005) · Neuropsychobiology · doi:10.1159/000087097 · Cited by 1,605 · see citing works
Toxicity of iron and hydrogen peroxide: the Fenton reaction
Winterbourn, C. C. (1995) · Toxicology Letters · doi:10.1016/0378-4274(95)03532-x · Cited by 1,415 · see citing works
Depression Duration But Not Age Predicts Hippocampal Volume Loss in Medically Healthy Women with Recurrent Major Depression
Sheline, Y. I., Sanghavi, M., Mintun, M. A., & Gado, M. H. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-12-05034.1999 · Cited by 1,382 · see citing works
Chronic mild stress-induced anhedonia: A realistic animal model of depression
Willner, P., Muscat, R., & Papp, M. (1992) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80194-0 · Cited by 1,160 · see citing works
Is the forced swimming test a suitable model for revealing antidepressant activity?
Borsini, F., & Meli, A. (1988) · Psychopharmacology · doi:10.1007/bf00176837 · Cited by 1,054 · see citing works
The forced swimming test as a model for core and component behavioral effects of antidepressant drugs
Lucki, I. (1997) · Behavioural Pharmacology · doi:10.1097/00008877-199711000-00010 · Cited by 803 · see citing works
Superoxide dismutase delays neuronal apoptosis: A role for reactive oxygen species in programmed neuronal death
Greenlund, L. J. S., Deckwerth, T. L., & Johnson, E. M. (1995) · Neuron · doi:10.1016/0896-6273(95)90287-2 · Cited by 738 · see citing works
Antioxidative enzyme activities and lipid peroxidation in major depression: alterations by antidepressant treatments
Bilici, M., Efe, H., Köroğlu, M. A., Uydu, H. A., Bekaroğlu, M., & Değer, O. (2001) · Journal of Affective Disorders · doi:10.1016/s0165-0327(00)00199-3 · Cited by 718 · see citing works
Animal Model of Depression
McKinney, W. T. (1969) · Archives of General Psychiatry · doi:10.1001/archpsyc.1969.01740200112015 · Cited by 710 · see citing works
Reduced neuronal size and glial cell density in area 9 of the dorsolateral prefrontal cortex in subjects with major depressive disorder
Cotter, D. (2002) · Cerebral Cortex · doi:10.1093/cercor/12.4.386 · Cited by 634 · see citing works
An animal model of anhedonia: attenuation of sucrose consumption and place preference conditioning by chronic unpredictable mild stress
Papp, M., Willner, P., & Muscat, R. (1991) · Psychopharmacology · doi:10.1007/bf02244188 · Cited by 542 · see citing works
Major depressive disorder is accompanied with oxidative stress: short-term antidepressant treatment does not alter oxidative-antioxidative systems
Sarandol, A., Sarandol, E., Eker, S. S., Erdinc, S., Vatansever, E., & Kirli, S. (2007) · Human Psychopharmacology: Clinical and Experimental · doi:10.1002/hup.829 · Cited by 486 · see citing works
Animal model of depression: Pharmacological sensitivity of a hedonic deficit
Katz, R. J. (1982) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(82)90053-3 · Cited by 480 · see citing works
Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death
Cregan, S. P., Fortin, A., MacLaurin, J. G., Callaghan, S. M., Cecconi, F., Yu, S.-W., Dawson, T. M., Dawson, V. L., Park, D. S., Kroemer, G., et al. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200202130 · Cited by 477 · see citing works
Regulation of adult neurogenesis by antidepressant treatment
Duman, R. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00358-x · Cited by 463 · see citing works
Oxidative damage and major depression: the potential antioxidant action of selective serotonin re-uptake inhibitors
Khanzode, S. D., Dakhale, G. N., Khanzode, S. S., Saoji, A., & Palasodkar, R. (2003) · Redox Report · doi:10.1179/135100003225003393 · Cited by 458 · see citing works
Antioxidant enzyme activities and oxidative stress in affective disorders
Erkan Ozcan, M., Gulec, M., Ozerol, E., Polat, R., & Akyol, O. (2004) · International Clinical Psychopharmacology · doi:10.1097/00004850-200403000-00006 · Cited by 368 · see citing works
The interplay of glutathione-related processes in antioxidant defense
Cnubben, N. H. P., Rietjens, I. M. C. M., Wortelboer, H. M., van Zanden, J., & van BLADEREN, P. J. (2001) · Environmental Toxicology and Pharmacology · doi:10.1016/s1382-6689(01)00077-1 · Cited by 358 · see citing works
Chronic treatment of rats with the antidepressant amitriptyline attenuates the activity of the hypothalamic-pituitary-adrenocortical system
Reul, J. M. H. M., Stec, I. S. M., Söder, M., & Holsboer, F. (1993) · Endocrinology · doi:10.1210/endo.133.1.8391426 · Cited by 346 · see citing works
Modification of ion homeostasis by lipid peroxidation: roles in neuronal degeneration and adaptive plasticity
Mattson, M. P. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(97)01188-0 · Cited by 344 · see citing works
Animal models as simulations of depression
Willner, P. (1991) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(91)90529-2 · Cited by 335 · see citing works
Acute and chronic antidepressant drug treatment in the rat forced swimming test model of depression.
Detke, M. J., Johnson, J. E., & Lucki, I. (1997) · Experimental and Clinical Psychopharmacology · doi:10.1037/1064-1297.5.2.107 · Cited by 318 · see citing works
Lower serum vitamin E concentrations in major depression
Maes, M. H. J., Vos, N. D., Pioli, R., Demedts, P., Wauters, A., Neels, H. M., & Christophe, A. B. (2000) · Journal of Affective Disorders · doi:10.1016/s0165-0327(99)00121-4 · Cited by 274 · see citing works
Protein oxidation and cellular homeostasis: Emphasis on metabolism
Cecarini, V., Gee, J., Fioretti, E., Amici, M., Angeletti, M., Eleuteri, A. M., & Keller, J. N. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.08.039 · Cited by 274 · see citing works
Antioxidant potential of vitamins A, E and C in modulating oxidative stress in rat brain
Zaidi, S. K., & Banu, N. (2003) · Clinica Chimica Acta · doi:10.1016/j.cccn.2003.11.003 · Cited by 263 · see citing works
Self-citation
Enhancement of some 5-HT-dependent behavioural responses following repeated immobilization in rats
Kennett, G. A., Dickinson, S. L., & Curzon, G. (1985) · Brain Research · doi:10.1016/0006-8993(85)90684-5 · Cited by 254 · see citing works
Thiol-mediated redox regulation of apoptosis. Possible roles of cellular thiols other than glutathione in T cell apoptosis.
Sato, N., Iwata, S., Nakamura, K., et al. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.154.7.3194 · Cited by 241 · see citing works
Evidence for oxidative stress in the frontal cortex in patients with recurrent depressive disorder—A postmortem study
Michel, T. M., Frangou, S., Thiemeyer, D., Camara, S., Jecel, J., Nara, K., Brunklaus, A., Zoechling, R., & Riederer, P. (2007) · Psychiatry Research · doi:10.1016/j.psychres.2006.04.013 · Cited by 218 · see citing works
Antidepressant treatment with tianeptine reduces apoptosis in the hippocampal dentate gyrus and temporal cortex
Lucassen, P. J., Fuchs, E., & Czéh, B. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.12.014 · Cited by 201 · see citing works
Stress Impairs LTP and Hippocampal‐Dependent Memorya
Diamond, D. M., & ROSE, G. M. (1994) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1994.tb39271.x · Cited by 195 · see citing works
Modulation ofin vivooxidative status by exogenous corticosterone and restraint stress in rats
Zafir, A., & Banu, N. (2008) · Stress · doi:10.1080/10253890802234168 · Cited by 192 · see citing works
Self-citation
The course of nitric oxide and superoxide dismutase during treatment of bipolar depressive episode
Selek, S., Savas, H. A., Gergerlioglu, H. S., Bulbul, F., Uz, E., & Yumru, M. (2008) · Journal of Affective Disorders · doi:10.1016/j.jad.2007.08.006 · Cited by 172 · see citing works
Chronic disease and mental disorder
Verhaak, P. F. M., Heijmans, M. J. W. M., Peters, L., & Rijken, M. (2005) · Social Science & Medicine · doi:10.1016/j.socscimed.2004.06.012 · Cited by 164 · see citing works
Effect of oxidative stress on receptors and signal transmission
VLIET, A. V. D., & Bast, A. (1992) · Chemico-Biological Interactions · doi:10.1016/0009-2797(92)90055-p · Cited by 157 · see citing works
Antioxidant potential of fluoxetine in comparison to Curcuma longa in restraint-stressed rats
Zafir, A., & Banu, N. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.05.062 · Cited by 156 · see citing works
Self-citation
Animal models of depression: validity and applications.
Willner, P. (1995) · PubMed · Cited by 148 · see citing works
Measures of Prefrontal System Dysfunction in Posttraumatic Stress Disorder
Koenen, K. C., Driver, K. L., Oscar‐Berman, M., Wolfe, J., Folsom, S., Huang, M. T., & Schlesinger, L. (2001) · Brain and Cognition · doi:10.1006/brcg.2000.1256 · Cited by 137 · see citing works
Stressor-induced anhedonia in the mesocorticolimbic system
Zacharko, R. M., & Anisman, H. (1991) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80032-6 · Cited by 135 · see citing works
Effects of Antioxidant Vitamins on Glutathione Depletion and Lipid Peroxidation Induced by Restraint Stress in the Rat Liver
Zaidi, S. K., Al‐Qirim, T. M., & Banu, N. (2005) · Drugs in R&D · doi:10.2165/00126839-200506030-00004 · Cited by 132 · see citing works
Self-citation
Effect of various classes of antidepressants in behavioral paradigms of despair
Kulkarni, S. K., & Dhir, A. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.05.002 · Cited by 127 · see citing works
Possible connections among job stress, depressive symptoms, lipid modulation and antioxidants
Tsuboi, H., Tatsumi, A., Yamamoto, K., Kobayashi, F., Shimoi, K., & Kinae, N. (2006) · Journal of Affective Disorders · doi:10.1016/j.jad.2005.12.010 · Cited by 119 · see citing works
Amitriptyline and fluoxetine protect PC12 cells from cell death induced by hydrogen peroxide
Kolla, N. J., Wei, Z., Richardson, J. S., & Li, X. (2005) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0528 · Cited by 113 · see citing works
Vulnerability to glucose deprivation injury correlates with glutathione levels in astrocytes
Papadopoulos, M. C., Koumenis, I. L., Dugan, L. L., & Giffard, R. G. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01293-0 · Cited by 105 · see citing works
Degeneration of neuronal cells due to oxidative stress—microglial contribution
Koutsilieri, E., Scheller, C., Tribl, F., & Riederer, P. F. (2002) · Parkinsonism & Related Disorders · doi:10.1016/s1353-8020(02)00021-4 · Cited by 81 · see citing works
Interactions between endocannabinoids and stress-induced decreased sensitivity to natural reward
Rademacher, D. J., & Hillard, C. J. (2006) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.12.013 · Cited by 79 · see citing works
Shuttle-box deficits induced by chronic variable stress: Reversal by imipramine administration
Murua, V. S., Gomez, R. A., Andrea, M. E., & Molina, V. A. (1991) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(91)90599-w · Cited by 72 · see citing works
Paradoxical effects of chronic corticosterone on forced swim behaviours in aged male and female rats
Brotto, L. A., Gorzalka, B. B., & Barr, A. M. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)01148-7 · Cited by 70 · see citing works
[Validation of an animal model of anhedonia, a major symptom of depression].
Moreau, J. (1997) · PubMed · Cited by 67 · see citing works
Caffeic acid attenuates the decrease in cortical BDNF mRNA expression induced by exposure to forced swimming stress in mice
Takeda, H., Tsuji, M., Yamada, T., Masuya, J., Matsushita, K., Tahara, M., Iimori, M., & Matsumiya, T. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.01.026 · Cited by 60 · see citing works
Glutathione as a cerebral substrate in depressive behavior
Pal, S. N., & Dandiya, P. C. (1994) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(94)90191-0 · Cited by 54 · see citing works
Restraint stress-induced changes in saccharin preference: The effect of antideprressive treatment and diazepam
Płaźnik, A., Stefański, R., & Kostowski, W. (1989) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(89)90466-8 · Cited by 40 · see citing works
Antidepressants upregulate messenger RNA levels of the neuroprotective enzyme superoxide dismutase (SOD1).
Li, X.-M., Chlan‐Fourney, J., Juorio, A. V., Bennett, V. L., Shrikhande, S., & Bowen, R. (2000) · PubMed Central · Cited by 38 · see citing works
Evaluation of a salivary based combined dexamethasone/CRH test in patients with major depression
Baghai, T. C., Schüle, C., Zwanzger, P., Minov, C., Holme, C., Padberg, F., Bidlingmaier, M., Strasburger, C. J., & Rupprecht, R. (2002) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(01)00060-9 · Cited by 36 · see citing works
Ca2+‐independent caspase‐3 but not Ca2+‐dependent caspase‐2 activation induced by oxidative stress leads to SH‐SY5Y human neuroblastoma cell apoptosis
Amoroso, S., D'Alessio, A., Sirabella, R., Renzo, G. D., & Annunziato, L. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10199 · Cited by 33 · see citing works
Oxidative stress related markers in the “VITA” and the centenarian projects
Grünblatt, E., Schlosser, R. J., Fischer, P. A., Fischer, M. O., Li, J., Koutsilieri, E., Wichart, I., Sterba, N., Rujescu, D., Møller, H. J., et al. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.06.001 · Cited by 32 · see citing works
Crete, channels, cells, circuits and computers1The Crete Course in Computational Neuroscience is supported by the European Commission (ERBFMMACT950036), by The Brain Science Foundation (Tokyo), by UNESCO (96GRE302) and by Sun Microsystems. The next course will take place from 7 September — 3 October 1997. More information can be found at http://bbf-www.uia.ac.be/Crete_index.html or by writing to Prof. E. De Schutter, Born-Bunge Foundation, University of Antwerp —UIA, Universiteitsplein 1, B2610 Antwerp, Belgium.1
Ullman, S., Roth, A., Thomson, A. M., et al. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)30020-9 · Cited by 29 · see citing works
Elimination of Ascorbic Acid-Induced Membrane Lipid Peroxidation and Serotonin Receptor Loss by Trolox-c, A Water Soluble Analogue of Vitamin E
Britt, S. G., Chiu, V. W. S., Redpath, G. T., & VandenBerg, S. R. (1992) · Journal of Receptor Research · doi:10.3109/10799899209074791 · Cited by 29 · see citing works
An endogenous opiate mechanism seems to be involved in stress-induced anhedonia
Zurita, A., Murúa, S., & Molina, V. A. (1996) · European Journal of Pharmacology · doi:10.1016/0014-2999(95)00754-7 · Cited by 29 · see citing works
Prior Morphine Facilitates the Occurrence of Immobility and Anhedonia Following Stress
Zurita, A., & Molina, V. A. (1998) · Physiology & Behavior · doi:10.1016/s0031-9384(98)00247-9 · Cited by 28 · see citing works
Saiko-ka-ryukotsu-borei-to, an herbal medicine, prevents chronic stress-induced disruption of glucocorticoid negative feedback in rats
Mizoguchi, K., Yuzurihara, M., Ishige, A., et al. (2002) · Life Sciences · doi:10.1016/s0024-3205(02)02199-9 · Cited by 24 · see citing works
"Swimming-induced Head Twitching" in Rats in the Forced Swimming Test Induced by Overcrowding Stress: A New Marker in the Animal Model of Depression?
Naitoh, H., Nomura, S., Kunimi, Y., et al. (1992) · The Keio Journal of Medicine · doi:10.2302/kjm.41.221 · Cited by 23 · see citing works
Oxidative biology: new intervention opportunities in psychiatry
Berk, M. (2007) · Acta Neuropsychiatrica · doi:10.1111/j.1601-5215.2007.00224.x · Cited by 14 · see citing works
The Action Potential Clamp as a Test of Space-Clamp Effectiveness - The Lettvin Analog Axon
Starzak, M. E., & Needle, M. N. (1983) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.1983.325212 · Cited by 8 · see citing works
Regulation of neurogenesis in the aging vertebrate brain: role of oxidative stress and neuropsychiatric factors
Kim, E., Shirvalkar, P. R., & Herrera, D. G. (2003) · Clinical Neuroscience Research · doi:10.1016/s1566-2772(03)00005-7 · Cited by 4 · see citing works

Flagged first, then by citations

Sorted by citations

A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro)degenerative processes in that illness
Maes, M., Galecki, P., Chang, Y. S., & Berk, M. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.05.004 · Cited by 1,140 · see citing works
Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a role in the pathophysiology of unipolar depression
Leonard, B., & Maes, M. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.12.005 · Cited by 805 · see citing works
New drug targets in depression: inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways. And new drug candidates—Nrf2 activators and GSK-3 inhibitors
Maes, M., Fišar, Z., Medina, M., Scapagnini, G., Nowak, G., & Berk, M. (2012) · Inflammopharmacology · doi:10.1007/s10787-011-0111-7 · Cited by 325 · see citing works
Depression gets old fast: do stress and depression accelerate cell aging?
Wolkowitz, O. M., Epel, E. S., Reus, V. I., & Mellon, S. H. (2010) · Depression and Anxiety · doi:10.1002/da.20686 · Cited by 298 · see citing works
Reactive Oxygen Species: Physiological and Physiopathological Effects on Synaptic Plasticity: Supplementary Issue: Brain Plasticity and Repair
Beckhauser, T. F., Francis-Oliveira, J., & De Pasquale, R. (2016) · Journal of Experimental Neuroscience · doi:10.4137/jen.s39887 · Cited by 301 · see citing works
Oxidative stress as an etiological factor and a potential treatment target of psychiatric disorders. Part 2. Depression, anxiety, schizophrenia and autism
Smaga, I., Niedzielska, E., Gawlik, M., Moniczewski, A., Krzek, J., Przegaliński, E., Pera, J., & Filip, M. (2015) · Pharmacological Reports · doi:10.1016/j.pharep.2014.12.015 · Cited by 252 · see citing works
Neurovascular unit dysfunction with blood-brain barrier hyperpermeability contributes to major depressive disorder: a review of clinical and experimental evidence
Najjar, S., Pearlman, D. M., Devinsky, O., Najjar, A., & Zagzag, D. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-142 · Cited by 248 · see citing works
Preclinical and Clinical Evidence of Antioxidant Effects of Antidepressant Agents: Implications for the Pathophysiology of Major Depressive Disorder
Behr, G. A., Moreira, J. C. F., & Frey, B. N. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/609421 · Cited by 205 · see citing works
Effects of long-term antidepressant treatment on oxidative status in major depressive disorder: A 24-week follow-up study
Kotan, V. O., Sarandol, E., Kirhan, E., Ozkaya, G., & Kirli, S. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2011.03.021 · Cited by 149 · see citing works
Harmine and Imipramine Promote Antioxidant Activities in Prefrontal Cortex and Hippocampus
Réus, G. Z., Stringari, R. B., de Souza, B., Petronilho, F., Dal-Pizzol, F., Hallak, J. E., Zuardi, A. W., Crippa, J. A., & Quevedo, J. (2010) · Oxidative Medicine and Cellular Longevity · doi:10.4161/oxim.3.5.13109 · Cited by 110 · see citing works
Food‐derived hydrophilic antioxidant ergothioneine is distributed to the brain and exerts antidepressant effect in mice
Nakamichi, N., Nakayama, K., Ishimoto, T., Masuo, Y., Wakayama, T., Sekiguchi, H., Sutoh, K., Usumi, K., Iseki, S., & Kato, Y. (2016) · Brain and Behavior · doi:10.1002/brb3.477 · Cited by 107 · see citing works
Coenzyme Q10 displays antidepressant-like activity with reduction of hippocampal oxidative/nitrosative DNA damage in chronically stressed rats
Aboul-Fotouh, S. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2012.12.027 · Cited by 97 · see citing works
Venlafaxine protects against stress-induced oxidative DNA damage in hippocampus during antidepressant testing in mice
Abdel-Wahab, B. A., & Salama, R. H. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.07.015 · Cited by 86 · see citing works
Antidepressant-like effect of a Ginkgo biloba extract (EGb761) in the mouse forced swimming test: Role of oxidative stress
Rojas, P., Serrano-García, N., Medina-Campos, O. N., Pedraza-Chaverri, J., Ögren, S. O., & Rojas, C. (2011) · Neurochemistry International · doi:10.1016/j.neuint.2011.05.007 · Cited by 76 · see citing works
Impact of fluoxetine on liver damage in rats
Inkielewicz-Stępniak, I. (2011) · Pharmacological Reports · doi:10.1016/s1734-1140(11)70510-2 · Cited by 75 · see citing works
α-Tocopherol administration produces an antidepressant-like effect in predictive animal models of depression
Lobato, K. R., Cardoso, C. C., Binfaré, R. W., Budni, J., Wagner, C. L. R., Brocardo, P. S., de Souza, L. F., Brocardo, C., Flesch, S., Freitas, A. E., et al. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.02.002 · Cited by 67 · see citing works
Effects of Fluoxetine on the Oxidative Status of Peripheral Blood Leucocytes of Restraint-Stressed Mice: FLUOXETINE, OXIDATIVE STRESS AND LEUCOCYTES
Novío, S., Núñez, M. J., Amigo, G., & Freire-Garabal, M. (2011) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2011.00736.x · Cited by 60 · see citing works
Attenuation of acute restraint stress-induced depressive like behavior and hippocampal alterations with protocatechuic acid treatment in mice
Thakare, V. N., Dhakane, V. D., & Patel, B. M. (2017) · Metabolic Brain Disease · doi:10.1007/s11011-016-9922-y · Cited by 49 · see citing works
History of mental disorders and leukocyte telomere length in late adulthood: the Helsinki Birth Cohort Study (HBCS)
Savolainen, K., Räikkönen, K., Kananen, L., Kajantie, E., Hovatta, I., Lahti, M., Lahti, J., Pesonen, A.-K., Heinonen, K., & Eriksson, J. G. (2012) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2012.07.005 · Cited by 40 · see citing works

Differential Rearing Alters Forced Swim Test Behavior, Fluoxetine Efficacy, and Post-Test Weight Gain in Male Rats
Arndt, D. L., Peterson, C. J., & Cain, M. E. (2015) · PLoS ONE · doi:10.1371/journal.pone.0131709 · Cited by 34 · see citing works
Antidepressant behavioral effects of duloxetine and fluoxetine in the rat forced swimming test 1 Efeitos antidepressivos da duloxetina e da fluoxetina no teste do nado forçado em ratos
Ciulla, L., Menezes, H. S., Bueno, B. B. M., Schuh, A., & Abegg, M. P. (2007) · DOAJ (DOAJ: Directory of Open Access Journals) · doi:10.1590/s0102-86502007000500005 · Cited by 2 · see citing works
Effects of neuronal nitric oxide synthase on antidepressant-like effect of fluoxetine
Li, W. (2011) · Acta Universitatis Medicinalis Nanjing
Antidepressant-like effect of fluoxetine may depend on translocator protein activity and pretest session duration in forced swimming test in mice
Kudryashov, N. V., Калинина, Т. С., Shimshirt, A. A., Королев, А. О., Волкова, А. В., & Воронина, Т. А. (2017) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000359 · Cited by 9 · see citing works
Sex-dependent effects of fluoxetine and triiodothyronine in the forced swim test in rats
Lifschytz, T., Shalom, G., Lerer, B., & Newman, M. E. (2005) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2005.07.003 · Cited by 35 · see citing works

Authors: Zafir, A., Ara, A., & Banu, N.
Affiliations: Aligarh Muslim University (IN)
Corresponding author: Banu, Naheed
ORCID: Ara, Anjum
Banu, Naheed
Venue: Progress in Neuro-Psychopharmacology and Biological Psychiatry
Publisher: Elsevier BV
Published: 2009-03
Volume: 33
Issue: 2
Pages: 220-228
ISSN: 0278-5846 (ISSN-L)
DOI: 10.1016/j.pnpbp.2008.11.010
OpenAlex: W2074602237
Cited by: 183
References: 84
Citations by year: 2026: 2 · 2025: 4 · 2024: 5 · 2023: 5 · 2022: 7 · 2021: 8 · 2020: 7 · 2019: 7 · 2018: 6 · 2017: 15 · 2016: 15 · 2015: 13 · 2014: 20 · 2013: 15 · 2012: 17
FWCI: 8.66
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: Department of Science and Technology, Ministry of Science and Technology, India
Indian Council of Medical Research
University Grants Commission
Topics: Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: oxidative stress, antioxidant status, antidepressants, depression, restraint stress, fluoxetine, imipramine, venlafaxine, superoxide dismutase, catalase, glutathione, lipid peroxidation, protein carbonylation, neuroprotection, stress management
MeSH terms: Venlafaxine Hydrochloride, Animals, Antidepressive Agents, Antidepressive Agents, Tricyclic, Antioxidants, Body Weight, Cyclohexanols, Depressive Disorder, Food Preferences, Imipramine, Restraint, Physical, Stress, Psychological, Swimming, Taste, Lipid Peroxidation, Fluvoxamine, Antidepressive Agents, Second-Generation, Protein Carbonylation, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

In vivo antioxidant status: A putative target of antidepressant action

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks