Cortical thickness and subcortical structure volume abnormalities in patients with major depression with and without anxious symptoms
Open accessAbstract
BACKGROUND: Anxious depression is one of the common subtypes of major depressive disorder (MDD). Clinically, patients with anxious depression exhibit more severe depressive symptoms than patients with nonanxious depression. The aim of the present study was to explore the common and differing cortical and subcortical structural changes between patients with anxious and nonanxious depression. METHODS: = 43) that were matched for age, sex, and education level. All participants underwent T1-weighted MRI. The Freesurfer, which uses a set of automated sequences to analyze the abnormal changes of cortical thickness, cortical and subcortical structures, was used to process the T1 images. RESULTS: Compared to controls, MDD patients showed thinner cortical thickness in the left inferior temporal, the right superior temporal, and the right parsorbitalis, and a smaller volume of the left hippocampus. Compared to nonanxious depression, anxious depressive patients showed a cortical thinning of the left superior frontal and right superior temporal, as well as the right lingual, and significantly increased subcortical volume of the bilateral caudate nuclei. Correlation analysis showed that the volumes of the bilateral caudate nuclei were directly proportional to the anxiety/somatization factor score. CONCLUSIONS: These findings suggest that smaller hippocampal volume and atrophic prefrontal and temporal cortices might be a common pattern of cortical and subcortical alterations in patients with depression and/or anxiety. However, the change in the caudate nucleus volume may be indicative of anxious depression and may potentially be used to distinguish anxious from nonanxious depression.
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Higher innate cytokine production capacity, rather than higher basal inflammation, was associated with anxious distress as well as with other dimensional anxiety indicators in a large MDD sample.
“Moreover, higher innate cytokine production capacity, rather than higher basal inflammation, was associated with anxious distress as well as with other dimensional anxiety indicators in a large MDD sample [67”
From Patients with anxious depression: overview of prevalence, pathophysiology and impact on course and treatment outcome (2018) · cites this paper as [67]
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- Authors
- Zhao, K., Liu, H., Yan, R., Hua, L., Chen, Y., Shi, J., Lu, Q., & Yao, Z.
- Affiliations
- Nanjing Brain Hospital (CN)
- Research Center of Learning Science Southeast University Nanjing China
- Corresponding author
- Yao, Zhijian
- Venue
- Brain and Behavior
- Publisher
- Wiley
- Published
- 2017-06-27
- Volume
- 7
- Issue
- 8
- Pages
- e00754-e00754
- ISSN
- 2157-9032 (ISSN-L)
- 2162-3279
- PMC
- PMC5561315
- OpenAlex
- W2662725288
- Cited by
- 78
- References
- 50
- Citations by year
- 2025: 5 · 2024: 11 · 2023: 12 · 2022: 6 · 2021: 10 · 2020: 15 · 2019: 10 · 2018: 7 · 2017: 2
- FWCI
- 6.49
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Brain and Behavior (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81571639, 61372032)
- Natural Science Foundation of Jiangsu Province (BK20160142)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- anxious depression, major depressive disorder, cortical thickness, subcortical volume, hippocampal volume, caudate nucleus, cortical thinning, somatization, anxiety symptoms, prefrontal cortex, temporal cortex, brain structural changes
- MeSH terms
- Adult, Anxiety, Caudate Nucleus, Cerebral Cortex, Depression, Depressive Disorder, Major, Major Depressive Disorder, Female, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Organ Size, Statistics as Topic, Diagnostic and Statistical Manual of Mental Disorders
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