Structural brain changes in patients with recurrent major depressive disorder presenting with anxiety symptoms
Abstract
BACKGROUND AND PURPOSE: Major depressive disorder (MDD) presents with extensive clinical heterogeneity. In particular, overlap with anxiety symptoms is common during depressive episodes and as a comorbid disorder. The aim of this study was to test for morphological brain differences between patients having a history of recurrent MDD with, and without, anxiety symptoms (MDD+A and MDD-A). METHODS: T1-weighted magnetic resonance images of age-, gender- and ethnically matched groups of MDD+A (n= 49) and MDD-A (n= 96) patients were available for voxel-based morphometry analysis of regional gray matter (GM) volume differences. Brain structural images were also contrasted with 183 age-, gender-, and ethnicity-matched healthy controls. RESULTS: MDD+A patients had greater GM volume (P(FWE) = .002) than MDD-A patients in the right temporal cortex extending from the mid-posterior superior temporal gyrus into the posterior middle and inferior temporal gyrus. The MDD patients together showed lower GM volume than healthy controls in the superior parietal lobe. CONCLUSIONS: Regional volume differences in patients are consistent with altered neuronal or glial microstructure. The temporolateral cortical differences distinguishing the 2 MDD groups suggest neurobiological differences related to the expression of anxiety symptoms in depression and provide further rationale for considering these groups independently for therapeutic outcomes studies.
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Comorbid anxiety moderated stress-induced cortisol levels in MDD in a sex-dependent manner.
“whereas comorbid anxiety moderated stress-induced cortisol levels in MDD in a sex-dependent manner [71].”
From Patients with anxious depression: overview of prevalence, pathophysiology and impact on course and treatment outcome (2018) · cites this paper as [71]
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- Authors
- Inkster, B., Rao, A. W., Ridler, K., Nichols, T. E., Saemann, P. G., Auer, D. P., Holsboer, F., Tozzi, F., Muglia, P., Merlo-Pich, E., & Matthews, P. M.
- Affiliations
- GlaxoSmithKline (United Kingdom) (GB)
- ORCID
- Venue
- Journal of Neuroimaging
- Publisher
- Wiley
- Published
- 2010-10-26
- Volume
- 21
- Issue
- 4
- Pages
- 375-382
- ISSN
- 1051-2284 (ISSN-L)
- OpenAlex
- W1994094087
- Cited by
- 56
- References
- 56
- Citations by year
- 2026: 2 · 2024: 8 · 2023: 3 · 2022: 4 · 2020: 2 · 2019: 5 · 2018: 1 · 2017: 7 · 2016: 4 · 2015: 5 · 2014: 6 · 2013: 5 · 2012: 3
- FWCI
- 2.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroimaging (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- major depressive disorder, recurrent depression, anxiety symptoms, comorbidities, gray matter volume, brain structure, right temporal cortex, superior parietal lobule, voxel-based morphometry
- MeSH terms
- Adult, Aged, Anxiety, Brain, Major Depressive Disorder, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged
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