An Overview of Neuroprotective and Cognitive Enhancement Properties of Lignans from Schisandra Chinensis

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Schisandrene, a Dibenzocyclooctadiene Lignan from Schisandra chinensis: Structure−Antioxidant Activity Relationships of Dibenzocyclooctadiene Lignans

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Gomisin A improves scopolamine-induced memory impairment in mice

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Schisandrin B exerts anti-neuroinflammatory activity by inhibiting the Toll-like receptor 4-dependent MyD88/IKK/NF-κB signaling pathway in lipopolysaccharide-induced microglia

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Dibenzocyclooctadiene lignans from Schisandra chinensis protect primary cultures of rat cortical cells from glutamate‐induced toxicity

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The effects of lignan-riched extract of Shisandra chinensis on amyloid-β-induced cognitive impairment and neurotoxicity in the cortex and hippocampus of mouse

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Schizandrin A Inhibits Microglia-Mediated Neuroninflammation through Inhibiting TRAF6-NF-κB and Jak2-Stat3 Signaling Pathways

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Optimization of conditions of solvent-free microwave extraction and study on antioxidant capacity of essential oil from Schisandra chinensis (Turcz.) Baill

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Schizandrin, an Antioxidant Lignan fromSchisandra chinensis,Ameliorates Aβ1–42-Induced Memory Impairment in Mice

Hu, D., Cao, Y., He, R., Han, N., Liu, Z., Miao, L., & Yin, J. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/721721 · Cited by 92 · see citing works

Prevention of scopolamine-induced memory deficits by schisandrin B, an antioxidant lignan fromSchisandra chinensisin mice

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Neuroprotective effects of Schisandrin B against transient focal cerebral ischemia in Sprague–Dawley rats

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Gomisin A inhibits lipopolysaccharide-induced inflammatory responses in N9 microglia via blocking the NF-κB/MAPKs pathway

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Schisantherin A protects against 6-OHDA-induced dopaminergic neuron damage in zebrafish and cytotoxicity in SH-SY5Y cells through the ROS/NO and AKT/GSK3β pathways

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Schisandra chinensis produces the antidepressant-like effects in repeated corticosterone-induced mice via the BDNF/TrkB/CREB signaling pathway

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Schisandrin B Enhances Cerebral Mitochondrial Antioxidant Status and Structural Integrity, and Protects against Cerebral Ischemia/Reperfusion Injury in Rats

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Schisandrin B shows neuroprotective effect in 6-OHDA-induced Parkinson’s disease via inhibiting the negative modulation of miR-34a on Nrf2 pathway

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Recent Advances in the Metabolic Engineering of Lignan Biosynthesis Pathways for the Production of Transgenic Plant-Based Foods and Supplements

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Protective effects of dibenzocyclooctadiene lignans from Schisandra chinensis against beta‐amyloid and homocysteine neurotoxicity in PC12 cells

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Schisantherin A recovers Aβ-induced neurodegeneration with cognitive decline in mice

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Neuroprotective phenolics in medicinal plants

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Schisandrin B protects against tert-butylhydroperoxide induced cerebral toxicity by enhancing glutathione antioxidant status in mouse brain

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Schisandrin B, attenuates cisplatin-induced oxidative stress, genotoxicity and neurotoxicity through modulating NF-κB pathway in mice

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Neuroprotective effect of schizandrin A on oxygen and glucose deprivation/reperfusion-induced cell injury in primary culture of rat cortical neurons

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Effect of a combination of extract from several plants on Cell‐mediated and humoral immunity of patients with advanced ovarian cancer

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Deoxyschizandrin Isolated from the Fruits of Schisandra chinensis Ameliorates Aβ1-42-induced Memory Impairment in Mice

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Pharmacological studies on the anxiolytic effect of standardized Schisandra lignans extract on restraint-stressed mice

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Schizandrin C exerts anti-neuroinflammatory effects by upregulating phase II detoxifying/antioxidant enzymes in microglia

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Schisandrin C Ameliorates Learning and Memory Deficits by Aβ1-42-induced Oxidative Stress and Neurotoxicity in Mice

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Pharmacological evaluation of sedative and hypnotic effects of schizandrin through the modification of pentobarbital-induced sleep behaviors in mice

Zhang, C., Zhao, X. D., Mao, X., Liu, A., Liu, Z., Li, X., Bi, K., & Jia, Y. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.09.012 · Cited by 46 · see citing works

Sedative and hypnotic effects of supercritical carbon dioxide fluid extraction from Schisandra chinensis in mice

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Total Lignans of Schisandra chinensis Ameliorates Aβ1-42-Induced Neurodegeneration with Cognitive Impairment in Mice and Primary Mouse Neuronal Cells

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Discovery of novel anti-parkinsonian effect of schisantherin A in in vitro and in vivo

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The effect of Schisandra chinensis extracts on depression by noradrenergic, dopaminergic, GABAergic and glutamatergic systems in the forced swim test in mice

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Neuroprotective effects of α-iso-cubebene against glutamate-induced damage in the HT22 hippocampal neuronal cell line

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Lignans from Schisandra chinensis ameliorate cognition deficits and attenuate brain oxidative damage induced by D-galactose in rats

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Isolation of lignans from Schisandra chinensis with anti-proliferative activity in human colorectal carcinoma: Structure–activity relationships

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Selective Gelatinase Inhibitor Neuroprotective Agents Cross the Blood-Brain Barrier

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Investigation of pharmacokinetics, tissue distribution and excretion of schisandrin B in rats by HPLC–MS/MS

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Authentication of Schisandra chinensis and Schisandra sphenanthera in Chinese patent medicines

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Schisantherin B ameliorates Aβ 1–42 -induced cognitive decline via restoration of GLT-1 in a mouse model of Alzheimer's disease

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Smashing Tissue Extraction of Five Lignans From the Fruit ofSchisandra chinensis

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Antitumor and antiangiogenic activity of Schisandra chinensis polysaccharide in a renal cell carcinoma model

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Methylenedioxy group and cyclooctadiene ring as structural determinants of schisandrin in protecting against myocardial ischemia-reperfusion injury in rats

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UFLC–MS/MS method for simultaneous determination of six lignans of Schisandra chinensis (Turcz.) Baill. in normal and insomniac rats brain microdialysates and homogenate samples: towards an in‐depth study for its sedative‐hypnotic activity

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Structure-Activity Relationships of Lignans from Schisandra chinensis as Platelet Activating Factor Antagonists.

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Enhanced oral bioavailability of Wurenchun (Fructus Schisandrae ChinensisExtracts) by self-emulsifying drug delivery systems

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Schizandrin reverses memory impairment in rats

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Transport ofSchisandra chinensisextract and its biologically-active constituents across Caco-2 cell monolayers — an in-vitro model of intestinal transport

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A randomized, double-blind, placebo-controlled trial of <i>Schisandra chinensis</i> for menopausal symptoms

Park, J. Y., & Kim, K. H. (2016) · Climacteric · doi:10.1080/13697137.2016.1238453 · Cited by 32 · see citing works

Comparison of anti‐inflammatory potential of four different dibenzocyclooctadiene lignans in microglia; action via activation of PKA and Nrf‐2 signaling and inhibition of MAPK/STAT/NF‐κB pathways

Park, S. Y., Bae, Y., Ko, M. J., Lee, S. J., & Choi, Y. W. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300445 · Cited by 31 · see citing works

Gomisin N isolated from Schisandra chinensis augments pentobarbital-induced sleep behaviors through the modification of the serotonergic and GABAergic system

Zhang, C., Mao, X., Zhao, X. D., et al. (2014) · Fitoterapia · doi:10.1016/j.fitote.2014.04.017 · Cited by 31 · see citing works

Purification of lignans from Schisandra chinensis fruit by using column fractionation and supercritical antisolvent precipitation

Huang, T.-L., Lin, J. C.-T., Chyau, C.-C., Lin, K.-L., & Chang, C. J. (2013) · Journal of Chromatography A · doi:10.1016/j.chroma.2013.01.091 · Cited by 30 · see citing works

Chemical composition and antioxidant activity of essential oil from berries of<i>Schisandra chinensis</i>(Turcz.) Baill

Liu, C. J., Zhang, S. Q., Zhang, J. S., Liang, Q., & Li, D. S. (2012) · Natural Product Research · doi:10.1080/14786419.2011.636745 · Cited by 29 · see citing works

Schizandrin ameliorates ovariectomy‐induced memory impairment, potentiates neurotransmission and exhibits antioxidant properties

Jiang, Z., Wang, C.-Y., Xie, X., Yang, J., Huang, J., Cao, Z., Xiao, P., & Li, C. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13078 · Cited by 25 · see citing works

Studies on medicinal herbs for cognitive enhancement based on the text mining of Dongeuibogam and preliminary evaluation of its effects

Pak, M. E., Kim, Y. R., Kim, H. N., Ahn, S., Shin, H. K., Baek, J. U., & Choi, B. T. (2016) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2016.01.006 · Cited by 25 · see citing works

Ultrasound-assisted extraction and purification of schisandrin B from Schisandra chinensis (Turcz.) Baill seeds: Optimization by response surface methodology

Zhang, Y. B., Wang, L., Zhang, D. Y., et al. (2013) · Ultrasonics Sonochemistry · doi:10.1016/j.ultsonch.2013.09.009 · Cited by 24 · see citing works

(−)Schisandrin B ameliorates paraquat‐induced oxidative stress by suppressing glutathione depletion and enhancing glutathione recovery in differentiated PC12 cells

Lam, P. Y., & Ko, K. M. (2011) · BioFactors · doi:10.1002/biof.136 · Cited by 24 · see citing works

Schisandrin B protects rat cortical neurons against Abeta1-42-induced neurotoxicity.

Wang, B., & Wang, X. (2009) · PubMed · Cited by 24 · see citing works

Pharmacokinetic Study and Optimal Formulation of New Anti-Parkinson Natural Compound Schisantherin A

Sa, F., Guo, B. J., Li, S., Zhang, Z. J., Chan, H. M., Zheng, Y., & Lee, S. M. (2015) · Parkinson s Disease · doi:10.1155/2015/951361 · Cited by 23 · see citing works

α-Iso-cubebene exerts neuroprotective effects in amyloid beta stimulated microglia activation

Park, S. Y., Park, S. J., Park, N. J., Joo, W. H., Lee, S.-J., & Choi, Y.-W. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2013.09.053 · Cited by 23 · see citing works

Rapid determination and pharmacokinetics study of lignans in rat plasma after oral administration of Schisandra chinensis extract and pure deoxyschisandrin

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Schizandrin prevents dexamethasone-induced cognitive deficits

Xu, X., Zhou, X., Zhou, X., Zhang, Z., Liao, M., Gao, Q., & Luo, H. (2012) · Neuroscience Bulletin · doi:10.1007/s12264-012-1258-y · Cited by 22 · see citing works

Schisandrin B Protects Against Tacrine- and Bis(7)-tacrine-Induced Hepatotoxicity and Enhances Cognitive Function in Mice

Pan, S., Han, Y., Carlier, P. R., et al. (2002) · Planta Medica · doi:10.1055/s-2002-23145 · Cited by 22 · see citing works

Identification of Key Structural Characteristics of Schisandra chinensis Lignans Involved in P-Glycoprotein Inhibition

Slanina, J., Páchniková, G., Čarnecká, M., et al. (2014) · Journal of Natural Products · doi:10.1021/np500521v · Cited by 22 · see citing works

New Thymoquinol Glycosides and Neuroprotective Dibenzocyclooctane Lignans from the Rattan Stems of <i>Schisandra chinensis</i>

Yang, B., Guo, J., Li, Z., Wang, C., Wang, Z., Wang, Q., & Kuang, H. (2016) · Chemistry &amp; Biodiversity · doi:10.1002/cbdv.201500311 · Cited by 20 · see citing works

Protection of seven dibenzocyclooctadiene lignans from Schisandra chinensis against serum and glucose deprivation injury in SH‐SY5Y cells

Qun, E., Tang, M., Zhang, X., Shi, Y., Wang, D., Gu, Y., Li, S., Liang, X., Wang, Z., & Wang, C. (2015) · Cell Biology International · doi:10.1002/cbin.10537 · Cited by 19 · see citing works

Beneficial effect of (–)Schisandrin B against 3‐nitropropionic acid‐induced cell death in PC12 cells

Lam, P. Y., & Ko, K. M. (2012) · BioFactors · doi:10.1002/biof.1009 · Cited by 18 · see citing works

Comparative studies on the chemical composition and antioxidant activities of Schisandra chinensis and Schisandra sphenanthera fruits

Wang, Z., Chen, H., Zhang, W., Lan, G., & Zhang, L. (2011) · Journal of Medicinal Plants Research · doi:10.5897/jmpr.9000379 · Cited by 17 · see citing works

Analysis of the Active Compounds in Different Parts of the Schisandra chinensis Plant by Means of Pyrolysis-GC/MS

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Schisandrin A and B affect subventricular zone neurogenesis in mouse

Sun, Y., Cong, Y., Liu, Y., et al. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.06.032 · Cited by 16 · see citing works

Structure-Activity Relationship Study of Dibenzocyclooctadiene Lignans Isolated from Schisandra chinensis on Lipopolysaccharide-Induced Microglia Activation

Hu, D., Han, N., Yao, X., Liu, Z., Wang, Y., Yang, J., & Yin, J. (2014) · Planta Medica · doi:10.1055/s-0034-1368592 · Cited by 15 · see citing works

Effectiveness of the analogue of natural Schisandrin C (HpPro) in treatment of liver diseases: an experience in Indonesian patients.

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The Neuroprotective Effects of α-Iso-cubebene on Dopaminergic Cell Death: Involvement of CREB/Nrf2 Signaling

Park, S. Y., Son, B. G., Park, Y. H., Kim, C.-M., Park, G., & Choi, Y.-W. (2014) · Neurochemical Research · doi:10.1007/s11064-014-1371-6 · Cited by 12 · see citing works

Analysis of crude drugs using reversed-phase TLC/scanning densitometry. (II) Identification of ginseng, red ginseng, gentian, Japanese gentian, pueraria root, gardenia fruit, schisandra fruit and ginger

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Articles : Gomisin J with Protective Effect Against t-BHP-Induced Oxidative Damage in HT22 Cells from Schizandra chinensis

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Schisandrin B Enhances Glutathione Redox Cycling and Protects Against β-amyloid-induced Apoptosis in Human Neuroblastoma SH-SY5Y Cells: A Comparative Study of Various Phytochemicals

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[Chemical constituents from supercritical CO2 extraction of Schisandra chinensis].

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Anti-Anxiety Effect of Schisandra chinensis Baill Lignans on Mice in Elevated Plus Maze Test

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The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence

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<i>In Vitro</i> and <i>In Vivo</i> Anti‐AChE and Antioxidative Effects of <i>Schisandra chinensis</i> Extract: A Potential Candidate for Alzheimer’s Disease

Song, X., Wang, T., Guo, L., Jin, Y., Wang, J., Yin, G., Jiang, K., Wang, L., Huang, H., & Zeng, L. (2020) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2020/2804849 · Cited by 8 · see citing works

Dibenzocyclooctene lignan compounds isolated from the fruits of Schisandra chinensis Baill

Piao, L., Lee, Y.-J., PhamPhu, T., et al. (2005) · Natural Product Sciences · Cited by 6 · see citing works

[Lignans from different processed products of Schisandra chinensis fruits].

Huang, X., Song, F., Liu, Z., et al. (2008) · PubMed · Cited by 1 · see citing works

Influence of processing on lignans of Schisandra chinensis

Wang, Y. (2011) · Zhongchengyao · Cited by 1 · see citing works

Changes in lignans compounds and expression of genes in lignans biosynthetic pathways during the maturation of Schisandra chinensis fruit

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Quantitative Determination of Lignan Constituents from Schisandra chinensis by Liquid Chromatography

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