Cited by 10Origins and Evolution of LifeTissue Engineering and Regenerative Medicine3D Printing in Biomedical Research

Matching together living cells and prototissues: will there Be chemistry?

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Valente, Stefano, Galanti, Agostino, Maghin, Edoardo, Najdi, Nahid, Piccoli, Martina, Gobbo, Pierangelo·2024·ChemBioChem

Abstract

Scientific advancements in bottom‐up synthetic biology have led to the development of numerous models of synthetic cells, or protocells. To date, research has mainly focused on increasing the (bio)chemical complexity of these bioinspired micro‐compartmentalized systems, yet the successful integration of protocells with living cells remains one of the major challenges in bottom‐up synthetic biology. In this review, we aim to summarize the current state of the art in hybrid protocell/living cell and prototissue/living cell systems. Inspired by recent breakthroughs in tissue engineering, we review the chemical, bio‐chemical, and mechano‐chemical aspects that hold promise for achieving an effective integration of non‐living and living matter. The future production of fully integrated protocell/living cell systems and increasingly complex prototissue/living tissue systems not only has the potential to revolutionize the field of tissue engineering, but also paves the way for new technologies in (bio)sensing, personalized therapy, and drug delivery.

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Cited by

Sorted by citations

Authors
Valente, S., Galanti, A., Maghin, E., Najdi, N., Piccoli, M., & Gobbo, P.
Affiliations
University of Trieste (IT)
Corresponding author
Gobbo, Pierangelo
Venue
ChemBioChem
Publisher
Wiley
Published
2024-08-07
Volume
25
Issue
18
Pages
e202400378-e202400378
ISSN
  • 1439-4227 (ISSN-L)
  • 1439-7633
OpenAlex
W4399897234
Cited by
10
References
170
Citations by year
2026: 6 · 2025: 4
FWCI
0.52
Type
journal article
Language
en
Open access
Locations
  • ChemBioChem (publishedVersion, other-oa)
  • PubMed (publishedVersion)
  • ArTS Archivio della ricerca di Trieste (University of Trieste https://www.units.it/) (submittedVersion, cc-by)
Funders
European Commission (PROTOMAT 101039578)
Topics
  • Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
  • Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
Keywords
protocells, artificial cells, bottom-up synthetic biology, cell integration, tissue engineering, biosensing, drug delivery, personalized treatment
MeSH terms
Humans, Tissue Engineering, Artificial Cells, Synthetic Biology

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