Cited by 503Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchDeep Brain Stimulation and Movement Disorders

The DOI matches its Crossref record; 100 of the 102 references it cites were found in a registry or an index.

The mesopontine rostromedial tegmental nucleus: A structure targeted by the lateral habenula that projects to the ventral tegmental area of Tsai and substantia nigra compacta

Open access

Jhou, Thomas C., Geisler, Stefanie, Marinelli, Michela, Degarmo, Beth A., Zahm, Daniel S.·2009·Journal of Comparative Neurology

DOI 10.1002/cne.21891PMC PMC3116663

Open this paper in CoChat — free account

Abstract

Prior studies revealed that aversive stimuli and psychostimulant drugs elicit Fos expression in neurons clustered above and behind the interpeduncular nucleus that project strongly to the ventral tegmental area (VTA) and substantia nigra (SN) compacta (C). Other reports suggest that these neurons modulate responses to aversive stimuli. We now designate the region containing them as the "mesopontine rostromedial tegmental nucleus" (RMTg) and report herein on its neuroanatomy. Dense micro-opioid receptor and somatostatin immunoreactivity characterize the RMTg, as do neurons projecting to the VTA/SNC that are enriched in GAD67 mRNA. Strong inputs to the RMTg arise in the lateral habenula (LHb) and, to a lesser extent, the SN. Other inputs come from the frontal cortex, ventral striatopallidum, extended amygdala, septum, preoptic region, lateral, paraventricular and posterior hypothalamus, zona incerta, periaqueductal gray, intermediate layers of the contralateral superior colliculus, dorsal raphe, mesencephalic, pontine and medullary reticular formation, and the following nuclei: parafascicular, supramammillary, mammillary, ventral lateral geniculate, deep mesencephalic, red, pedunculopontine and laterodorsal tegmental, cuneiform, parabrachial, and deep cerebellar. The RMTg has meager outputs to the forebrain, mainly to the ventral pallidum, preoptic-lateral hypothalamic continuum, and midline-intralaminar thalamus, but much heavier outputs to the brainstem, including, most prominently, the VTA/SNC, as noted above, and to medial tegmentum, pedunculopontine and laterodorsal tegmental nuclei, dorsal raphe, and locus ceruleus and subceruleus. The RMTg may integrate multiple forebrain and brainstem inputs in relation to a dominant LHb input. Its outputs to neuromodulatory projection systems likely converge with direct LHb projections to those structures.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1002/cne.21891

Cites

100 of 100 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Brain stem reticular formation and activation of the EEG
Moruzzi, G., & Magoun, H. W. (1949) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(49)90219-9 · Cited by 4,307
Hypothalamic regulation of sleep and circadian rhythms
Saper, C. B., Scammell, T. E., & Lu, J. (2005) · Nature · doi:10.1038/nature04284 · Cited by 2,804
Large-scale neurocognitive networks and distributed processing for attention, language, and memory
Mesulam, M. (1990) · Annals of Neurology · doi:10.1002/ana.410280502 · Cited by 2,684
Activity of norepinephrine-containing locus coeruleus neurons in behaving rats anticipates fluctuations in the sleep-waking cycle
Aston-Jones, G., & Bloom, F. (1981) · The Journal of Neuroscience · doi:10.1523/jneurosci.01-08-00876.1981 · Cited by 1,960
Histochemical mapping of nitric oxide synthase in the rat brain
Vincent, S. R., & Kimura, H. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90184-4 · Cited by 1,868
Mapping Patterns of c- fos Expression in the Central Nervous System After Seizure
Morgan, J. I., Cohén, D., Hempstead, J. L., & Curran, T. (1987) · Science · doi:10.1126/science.3037702 · Cited by 1,786
The Nature of the Arrestin·Receptor Complex Determines the Ultimate Fate of the Internalized Receptor
Pan, L., Gurevich, E. V., & Gurevich, V. V. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209532200 · Cited by 1,758
The projections of the ventral tegmental area and adjacent regions: a combined fluorescent retrograde tracer and immunofluorescence study in the rat
Swanson, L. W. (1982) · Brain Research Bulletin · doi:10.1016/0361-9230(82)90145-9 · Cited by 1,718
Differential expression of orexin receptors 1 and 2 in the rat brain
Marcus, J. N., Aschkenasi, C. J., Lee, C. E., Chemelli, R. M., Saper, C. B., Yanagisawa, M., & Elmquist, J. K. (2001) · Journal of Comparative Neurology · doi:10.1002/cne.1190 · Cited by 1,659
The sleep switch: hypothalamic control of sleep and wakefulness
Saper, C. B., Chou, T. C., & Scammell, T. E. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)02002-6 · Cited by 1,656

Flagged first, then by citations

Show all 102 references

2 of the 102 references couldn’t be matched to a known paper.

Research works printed but not linked: 2

Heimer L, 2008, Anatomy of neuropsychiatry: the new anatomy of the basal forebrain and its implications for neuropsychiatric disease
Jakab RL, 1995, The rat nervous system, 405

Sorted by citations

Items 401–500 of 500

Effects of predator odor stress on alcohol-induced conditioned taste aversion and lateral habenula cFos expression in rats
Brunke, O. R., Bonauto, S. M., Boshak, E. M., Rauch, M. J., & Weera, M. M. (2025) · Neuropharmacology · doi:10.1016/j.neuropharm.2025.110780 · Cited by 1
Lateral habenula and periaqueductal gray neurons signal reward prediction error and continuity of reward expectancy to drive reward-seeking behavior
Lee, H., & Hikosaka, O. (2026) · Cell Reports · doi:10.1016/j.celrep.2025.116907 · Cited by 1
Increased risk of suicide in substance use disorder: a neurobiological perspective
Thippaiah, S. M., Wang, M., Ransdell, M., Tang, Y., & Fanous, A. H. (2026) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2026.2618990 · Cited by 1
Tachykinin 1 neurons in the lateral habenula signal negative reward prediction error
Suzuki, K. E., Seagoe, T. A., Holcomb, B., Kuyat, J. R., & Sylwestrak, E. (2026) · Current Biology · doi:10.1016/j.cub.2026.04.032 · Cited by 2
Location and mapping of the human rostromedial tegmental nucleus and associated midbrain inhibitory nuclei regulating dopamine neurons
Filimontseva, A., Fu, Y., & Halliday, G. M. (2026) · Brain Structure and Function · doi:10.1007/s00429-026-03103-x · Cited by 1
Independent Heritability of Aversive Learning Influences on Cocaine-Seeking and Punishment Resistance in Rats
Eid, M., Pullmann, D., Nietert, P. J., Lipat, R., Rowley, C., & Jhou, T. C. (2026) · eNeuro · doi:10.1523/eneuro.0083-25.2026 · Cited by 1
The Diencephalon
Elisevich, L., Ascenzi, B. M., & Elisevich, K. V. (2024) · Elsevier eBooks · doi:10.1016/b978-0-12-822404-5.00002-4 · Cited by 1
Introduction
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.003.0001 · Cited by 1
Central Neural Circuits Regulating Maternal Behavior in Nonhuman Mammals
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.003.0005 · Cited by 1
Alloparental Behavior and Paternal Behavior in Nonhuman Mammals
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.003.0007 · Cited by 1
Por qué la democracia necesita del periodismo de investigación
Waisbord, S. (2001) · Hispana · Cited by 1
The brain at play: neural substrates of social play behaviour in adolescent rats
van Kerkhof, L. W. M. (2013) · Utrecht University Repository (Utrecht University) · Cited by 1
Neuroeconomic Perspectives on the Potent but Inconsistent Motivations Characteristic of Addiction
Melrose, A. J., Hsu, E., & Monterosso, J. R. (2015) · Wiley eBooks · doi:10.1002/9781118472415.ch19 · Cited by 1
Untitled work
(2012) · Figshare
The Role of the Dopamine D1-D2 Receptor Heteromer in Brain Reward Function: Relevance to Drug Addiction and Depression
Shen, Y. F. (2015) · TSpace (University of Toronto) · Cited by 1
Memory-specific encoding activities of the ventral tegmental area dopamine and GABA neuronsPreprint
Glykos, V., & Fujisawa, S. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.06.28.546967 · Cited by 1
Tachykinin 1-expressing neurons in the lateral habenula signal negative reward prediction errorPreprint
Suzuki, K. E., Seagoe, T. A., Holcomb, B., Kuyat, J. R., & Sylwestrak, E. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.11.680558 · Cited by 1
Mu opioid receptors in the habenula : dissecting reward and aversion in addiction
Boulos, L. (2017) · theses.fr (ABES) · doi:10.70675/4ec6ce3az48cbz4a77za34ezb8b76b41f629 · Cited by 1
Cannabinoid-Dopamine Interactions: Modulation of Midbrain DA Neurons by Endocannabinoids
Georges, F. E., & Melis, M. (2015) · Springer eBooks · doi:10.1007/978-1-4939-2294-9_17
Linking actions to outcomes : the role of the posterior pedunculopontine tegmental nucleus in instrumental learning
MacLaren, D. A. A. (2012) · St Andrews Research Repository (St Andrews Research Repository)
Circuitaria e assinatura neuroquímica das projeções entre a habenula lateral, o núcleo tegmental rostromedial e o núcleo dorsal da rafe.
Sego, C. (2013) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.42.2013.tde-14032014-082816
Organization of the Pallidal Projections of the Rostromedial Tegmental Nucleus of the Dog Brain
Gorbachevskaya, A. I. (2015) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-015-0159-8
Projeções diferenciadas da habênula lateral para o núcleo tegmental rostromedial e área tegmental ventral no rato.
Gonçalves, L. (2013) · doi:10.11606/t.42.2013.tde-20092013-105631
Going for Broke: Dopamine Influences Risky Choice
Moschak, T. M., & Carelli, R. M. (2014) · Neuron · doi:10.1016/j.neuron.2014.09.017
Regulation of GABAergic neuron identity and diversity in the developing midbrain
Achim, K. (2010) · Työväentutkimus Vuosikirja
THE MEDIATION OF FORMALIN PAIN BY THE FOREBRAIN MEDIAL SEPTUM
Andy, L. T. H. (2013) · National University of Singapore
Aferências hipotalâmicas para a área tegmental ventral, núcleo tegmental rostromedial e núcleo dorsal da rafe.
Lima, L. B. (2015) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.42.2015.tde-16102015-192516
"AFERÊNCIAS HIPOTALÂMICAS PARA A ÁREA TEGMENTAL VENTRAL, NÚCLEO TEGMENTAL ROSTROMEDIAL E NÚCLEO DORSAL DA RAFE."
Humana, E. F., & Andreas, M. (2015)
Exploring Sex Differences In Psychostimulant-induced Activation Of The Tail Of The Ventral Tegmental Area
Dennis, T. S. (2014) · UTA ResearchCommons (University of Texas Arlington)
Ventral Tegmental Area GABAA Receptors Mediate the Change from a Drug-naive to an Opiate- or Ethanol-deprived Motivational State
Ting‐A‐Kee, R. A. (2012) · TSpace (University of Toronto)
Burst Firing of the Ventral Tegmental Area Neurons through Bicuculline-Induced GABA-A Receptor Blockade
Tale, F., Pakdel, F. G., Shahabi, P., & Naderi, S. (2016) · The Neuroscience Journal of Shefaye Khatam · doi:10.18869/acadpub.shefa.4.2.33
The Role of the Habenulomesencephalic Circuit in Cocaine Addiction
Zuo, W., Krnjević, K., Bekker, A., & Ye, J.-H. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-803750-8.00032-4
A Subset of VTA DA Neurons Demonstrates High Sensitivity to Acute Ethanol and Enhanced Sensitivity after Adolescent Drinking
Avegno, E. M. (2016) · doi:10.7916/d8ws8t8k
Neural Circuit Mechanisms Underlying Dopamine Reward Prediction Errors
Tian, J. (2016) · Digital Access to Scholarship at Harvard (DASH) (Harvard University)
The Results of Yellow Fever Sanitation in Havana, Cuba, for the Year 1901 up to September 1st, Carried on upon the Basis that the Stegomyia Mosquito is the Sole Means of its Transmission.
Gorgas, W. C. (1901) · PubMed Central
Organization of the Connections of the Rostromedial Tegmental Nucleus with Structures of the Morphofunctional Basal Ganglia System in the Dog Brain
Gorbachevskaya, A. I. (2018) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-018-0582-8
СТРУКТУРНАЯ ОСНОВА ОБРАБОТКИ ИНФОРМАЦИИ В ПРОЕКЦИОННЫХ СИСТЕМАХ КАУДАЛЬНЫХ ЯДЕР СИСТЕМЫ БАЗАЛЬНЫХ ГАНГЛИЕВ, "Успехи физиологических наук"
Горбачевская, А. И. (2018) · Успехи физиологических наук · doi:10.7868/s0301179818030013
An Interface of the Taste and Reward Systems in the Brainstem and Its Role in Feeding
Saites, L. (2018) · doi:10.21007/etd.cghs.201.0456
奖赏环路与阿片成瘾:喙内侧被盖核的调节作用
Jing, W. U., Cui, R., Cuicui, S. U. N., & Li, X. (2019) · Advances in Psychological Science · doi:10.3724/sp.j.1042.2019.00060
Separate mesolimbic dopaminergic pathways mediate the opposing motivational effects of acute caffeine
Yee, M. (2018) · TSpace (University of Toronto)
Conexôes aferentes e eferentes do núcleo interpeduncular com enfoque especial para os circuitos entre a habênula, o núcleo interpeduncular e os núcleos da rafe.
Bueno, D. N. M. (2019) · doi:10.11606/t.42.2019.tde-25032019-094428
Evolutionary Perspectives on the Parental Brain
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.003.0011
Anxiety Reduction and Maternal Aggression in Postpartum Nonhuman Mammals
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.003.0006
Development of the Parental Brain in Nonhuman Mammals
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.003.0009
Development of the Parental Brain in Humans
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.003.0010
Brain Mechanisms Regulating Maternal Behavior in Nonhuman Mammals
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.003.0004
The Role of Ventral Tegmental Area and Nucleus Accumbens in the Kamin Blocking Effect
Aggarwal, M. (2019)
Baseline Lateral Habenula Firing Rate Negatively Correlates with Increase in Ethanol Intake over Days in Adult Long Evans RatsPreprint
Tandon, S. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.01.27.428307
The rostromedial tegmental nucleus: Features and links with alcohol and depression
Zuo, Q., Zuo, W., Eloy, J. D., & Ye, J.-H. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-817935-2.00031-3
Role of Deep Brain Stimulation in Treatment Resistant Depression: A Review Article
Khoshnevisan, A. (2021) · Psychology and Psychotherapy Research Study · doi:10.31031/pprs.2021.04.000598
Neural Circuits Underlying the Pathophysiology of Major Depression
Amidfar, M., & Kim, Y. (2022) · Neuromethods · doi:10.1007/978-1-0716-2083-0_3
Faculty Opinions recommendation of A neural circuit mechanism for encoding aversive stimuli in the mesolimbic dopamine system.
Berridge, K. C. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.734515518.793554226
Faculty Opinions recommendation of A neural circuit mechanism for encoding aversive stimuli in the mesolimbic dopamine system.
Schultz, W. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.734515518.793565159
Faculty Opinions recommendation of A unique population of ventral tegmental area neurons inhibits the lateral habenula to promote reward.
Russo, S. J., & Ables, J. L. (2014) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.718185776.793489484
Faculty Opinions recommendation of Behavioral and neurobiological mechanisms of punishment: implications for psychiatric disorders.
Vanderschuren, L. J. M. J. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.733127758.793560147
Faculty Opinions recommendation of Dopamine in motivational control: rewarding, aversive, and alerting.
Frank, M. J. (2010) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.7340957.7601055
The role of lateral habenula NMDA receptors in tramadol-induced conditioning
Hajikarim‐Hamedani, A., Heidari, A., Sadat‐Shirazi, M., Mahboubi, S., Raminfard, S., Khalifeh, S., & Zarrindast, M. (2023) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000730
Memory-specific encoding activities of the ventral tegmental area dopamine and GABA neuronsPreprint
Glykos, V., & Fujisawa, S. (2023) · eLife · doi:10.7554/elife.89743.1
Pumping the brakes: rostromedial tegmental inhibition of compulsive cocaine seekingPreprint
Vento, P. J., Watson, J. R., Pullmann, D., Black, S. L., Tomberlin, J., & Jhou, T. C. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.10.04.560908
Effects of Sex and Hierarchy on Empathic Allogrooming Behavior in RatsPreprint
Sun, W., Song, N., & Fan, P. (2023) · SSRN Electronic Journal · doi:10.2139/ssrn.4633680
Literature cited
(2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15596-3.16001-1
Memory-specific encoding activities of the ventral tegmental area dopamine and GABA neuronsPreprint
Glykos, V., & Fujisawa, S. (2024) · eLife · doi:10.7554/elife.89743.2
Circuits for anesthesia, unawareness, OIRD, sleep and memory replay: MHb→IPN→PAG + DRN + MRN→claustrum→cortex.Preprint
Vadovičová, K. (2024) · doi:10.14293/pr2199.000799.v1
Circuits for anesthesia, unawareness, OIRD, sleep and memory replay: MHb→IPN→PAG + DRN + MRN→claustrum→cortex.Preprint
Vadovičová, K. (2024) · doi:10.14293/pr2199.000799.v2
Preface
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.002.0006
Copyright Page
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.002.0003
Abbreviations Used for Major Brain Regions
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.002.0007
Dedication
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.002.0004
Circuits for anesthesia, unawareness, OIRD, sleep and memory replay: MHb→IPN→ PAG + DRN + MRN→claustrum→ cortical slow-waves.Preprint
Vadovičová, K. (2024) · doi:10.14293/pr2199.000799.v3
eLife Assessment: Ventral tegmental area interneurons revisited: GABA and glutamate projection neurons make local synapses
Day, J. J. (2024) · eLife · doi:10.7554/elife.100085.1.sa3
Reviewer #3 (Public Review): Ventral tegmental area interneurons revisited: GABA and glutamate projection neurons make local synapses
Oriol, L., Chao, M., Kollman, G. J., et al. (2024) · eLife · doi:10.7554/elife.100085.1.sa0
Reviewer #1 (Public Review): : Ventral tegmental area interneurons revisited: GABA and glutamate projection neurons make local synapses
Oriol, L., Chao, M., Kollman, G. J., et al. (2024) · eLife · doi:10.7554/elife.100085.1.sa2
Circuits for anesthesia, unawareness, OIRD, sleep and memory replay: MHb→IPN→ PAG + DRN + MRN→claustrum→ cortical slow-waves.Preprint
Vadovičová, K. (2024) · doi:10.14293/pr2199.000799.v4
Circuits for anesthesia, unawareness, OIRD, sleep and memory replay: MHb→IPN→ PAG + DRN + MRN→claustrum→ cortical slow-waves.Preprint
Vadovičová, K. (2024) · doi:10.14293/pr2199.000799.v5
Pharmacological blockade of glutamatergic input to the lateral habenula modulates consumption of palatable diet components in male Wistar ratsPreprint
Slomp, M., Spitters, M. T., van Bergen, J. L., van Irsen, A. A. S., Kool, T., Eggels, L., Mul, J. D., & la Fleur, S. E. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.02.610523
Periaqueductal gray passes over disappointment and signals continuity of remaining reward expectancyPreprint
Lee, H., & Hikosaka, O. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.12.17.628983
Ventral tegmental area interneurons revisited: GABA and glutamate projection neurons make local synapsesPreprint
Oriol, L., Chao, M., Kollman, G. J., Dowlat, D. S., Singhal, S. M., Steinkellner, T., & Hnasko, T. S. (2025) · eLife · doi:10.7554/elife.100085.2
Stressed Avoider rats show blunted sensitivity to alcohol’s aversive effects: Potential contributions of the lateral habenula and lateral hypothalamusPreprint
Brunke, O. R., Bonauto, S. M., Boshak, E. M., Rauch, M., & Weera, M. M. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.23.655819
VTA GABA Cell Bipotential Induction of iLTP or iLTD Synaptic Plasticity is Input Selective, where iLTD is Uniquely Eliminated by CocainePreprint
Wu, B. J., Hoffman, S., Urey, H., Forbush, I., Bird, D., Brailsford, C., & Edwards, J. G. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.06.680313
Chemogenetic activation of an A2 nucleus of the solitary tract to lateral parabrachial nucleus noradrenergic pathway blunts binge-like ethanol intake and promotes aversive unconditioned responses in male and female mice
Drinkuth, C. R., Dornellas, A. P. S., Guarino, S., Navarro, M., & Thiele, T. E. (2025) · Neuropharmacology · doi:10.1016/j.neuropharm.2025.110792
Mapping the Fasciculus Retroflexus A review on the implications of the lateral habenula in the dopaminergic and serotonergic midbrain areas
Engberink, A. H. O. O. (2011) · Utrecht University Repository (Utrecht University)
マウスにおける手綱核-脚間核回路の機能解析
小林, 祐. (2013) · Institutional Repositories DataBase (IRDB) · doi:10.15017/1398539
Inhibition of the LHb glutamatergic pathway ameliorates depressive-like behaviors in a 6-hydroxydopamine-induced Parkinson's disease mouse model
Cui, J., Di, Z. H. A. O., Liu, J., Qian, J., Wang, J., & Shi, L. (2026) · Neurobiology of Disease · doi:10.1016/j.nbd.2026.107293
Caractérisation des circuits neuronaux contrôlant l’activité des neurones dopaminergiques de l’aire tegmentale ventrale
Jalabert, M. (2011) · theses.fr (ABES) · doi:10.70675/4d4ba3a7zce38z40f7za8adz84111f198b6f
When anatomy drives physiology : expanding the actor-critic model of the basal ganglia to new subthalamus connections
Haynes, W. I. A. (2014) · theses.fr (ABES) · doi:10.70675/bc75d92dz55b5z447azbb70z2e28f320b4e7
Reversal strategies within the lateral habenula to ameliorate depressive-like behaviors
Tchenio, A. (2017) · theses.fr (ABES) · doi:10.70675/981419c3z06f5z440dz9e73ze1d620709914
Caractérisation moléculaire et pharmacologique de l'horloge circadienne située dans l'habénula
Salaberry, N. L. (2018) · theses.fr (ABES) · doi:10.70675/8d54db3cz09e1z4999zbcb5za35dc04505ca
A study of mouse central extended amygdala : general connectivity and cell-type specific circuits ; functional implications in pain
Ye, J. (2018) · theses.fr (ABES) · doi:10.70675/7d321ecaza13fz4852z82eaz45263b2adf7b
La queue de l’aire tegmentale ventrale : définition anatomo-moléculaire, implication dans la réponse aux stimuli aversifs et influence sur la voie nigrostriée
Faivre, F. (2018) · doi:10.70675/b30f731az3333z44bbz8cb6za26c36c3c9a8
Potentialisation de la réponse antidépressive par la lumière : étude préclinique
Delcourte, S. (2019) · theses.fr (ABES) · doi:10.70675/7468b6d3zbf12z4888z88afzc63efcc91723
Régulation du sommeil et de l’anxiété par VGLUT3, le transporteur vésiculaire du glutamate de type 3
Henderson, F. J. (2019) · theses.fr (ABES) · doi:10.70675/72ea7d04ze3b3z4768zab1fz66b684e1ed22
Data-driven computational modelling for some of the implications of dopamine in the brain : From subcellular signalling to area networks
Foncelle, A. (2018) · theses.fr (ABES) · doi:10.70675/8bee2d7fze7e5z4695zba99zfe3380089e86
tVTA controls dual dopaminergic inputs to the external Globus PallidusPreprint
Lebouc, M., Fois, G. R., Bilella, A., Baufreton, J., Barrot, M., & Georges, F. E. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.20.719622
A novel theory of rapid eye movement sleep as an integral component of the seasonal timekeeping apparatus
Raitiere, M. N. (2026) · Frontiers in Neuroscience · doi:10.3389/fnins.2026.1838966
Cannabis
Koob, G. F., Arends, M. A., McCracken, M. L., & Moal, M. L. (2026) · Elsevier eBooks · doi:10.1016/b978-0-12-816791-5.00001-7
Evolutionary rise of a synaptic mechanism for creating and diversifying key reinforcement signalsPreprint
Rodríguez-Sosa, N., Rios, L., Lin, Y., Rybalchenko, V., Sharma, Y., Hajeissa, A., Chambers, I., Wang, N.-S., Rajesh, R., Narla, V., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.07.31.742134
Role of the tail of the ventral tegmental area in the regulation of maternal behaviour: a pharmacological study in postpartum rats
Pérez-Gozalbo, C., Sanahuja-Irene, S., Martínez‐Garciá, F., & Sánchez-Catalán, M. J. (2026) · Neuropharmacology · doi:10.1016/j.neuropharm.2026.111147
Nociceptive responses and resting-state functional connectivity of the human midbrain tegmentum
Cao, A., Morris, K., van der Heijden, H. C., van Gool, R., Gregory, S. R., Gonzalez–Heydrich, J., Paech, D., Berretta, S., & Upadhyay, J. (2026) · Brain Structure and Function · doi:10.1007/s00429-026-03203-8
Dynamic dopamine signaling, prediction error, and microcircuit mechanisms in stress-induced depression-like behaviors
Mahmud, A., & Efremov, L. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1948686
tVTA controls two distinct dopaminergic inputs to the external Globus PallidusPreprint
Lebouc, M., Fois, G. R., Bilella, A., Baufreton, J., Barrot, M., & Georges, F. E. (2026) · Research Square · doi:10.21203/rs.3.rs-11143061/v1

Authors: Jhou, T. C., Geisler, S., Marinelli, M., Degarmo, B. A., & Zahm, D. S.
Affiliations: National Institutes of Health (US)
Saint Louis University (US)
Rosalind Franklin University of Medicine and Science (US)
Corresponding author: Jhou, Thomas C.
Zahm, Daniel S.
ORCID: Jhou, Thomas C.
Geisler, Stefanie
Marinelli, Michela
Zahm, Daniel S.
Venue: Journal of Comparative Neurology
Publisher: Wiley
Published: 2009-02-20
Volume: 513
Issue: 6
Pages: 566-596
ISSN: 0021-9967 (ISSN-L)
1096-9861
DOI: 10.1002/cne.21891
PMC: PMC3116663
OpenAlex: W2085520758
Cited by: 503
References: 102
Citations by year: 2026: 16 · 2025: 15 · 2024: 35 · 2023: 13 · 2022: 17 · 2021: 39 · 2020: 48 · 2019: 39 · 2018: 34 · 2017: 27 · 2016: 34 · 2015: 26 · 2014: 38 · 2013: 36 · 2012: 28
FWCI: 11.61
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: The Journal of Comparative Neurology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Heart, Lung, and Blood Institute (HL 60292, P50HL060292)
National Institute of Mental Health (MH-12370, F31MH012370)
National Institute on Drug Abuse (DA020654, R01DA020654)
National Institute of Neurological Disorders and Stroke (NS23805, R01NS023805)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
Keywords: rostromedial tegmental nucleus, lateral habenula, ventral tegmental area, substantia nigra pars compacta, mesopontine tegmentum, interpeduncular nucleus, Fos expression, aversive stimuli, psychostimulants, mu-opioid receptor, somatostatin, GAD67, neuroanatomy, brainstem projections, neuromodulation, pedunculopontine nucleus, laterodorsal tegmentum, dorsal raphe nucleus, locus coeruleus
MeSH terms: Animals, Cocaine, Glutamate Decarboxylase, Male, Methamphetamine, Neural Pathways, RNA, Messenger, Self Administration, Somatostatin, Substantia Nigra, Sulfur Radioisotopes, Tegmentum Mesencephali, Gene Expression, Proto-Oncogene Proteins c-fos, Rats, Sprague-Dawley, Receptors, Opioid, mu, Ventral Tegmental Area, Habenula, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The mesopontine rostromedial tegmental nucleus: A structure targeted by the lateral habenula that projects to the ventral tegmental area of Tsai and substantia nigra compacta

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks