The DOI matches its Crossref record; 100 of the 102 references it cites were found in a registry or an index.
The mesopontine rostromedial tegmental nucleus: A structure targeted by the lateral habenula that projects to the ventral tegmental area of Tsai and substantia nigra compacta
Open accessAbstract
Prior studies revealed that aversive stimuli and psychostimulant drugs elicit Fos expression in neurons clustered above and behind the interpeduncular nucleus that project strongly to the ventral tegmental area (VTA) and substantia nigra (SN) compacta (C). Other reports suggest that these neurons modulate responses to aversive stimuli. We now designate the region containing them as the "mesopontine rostromedial tegmental nucleus" (RMTg) and report herein on its neuroanatomy. Dense micro-opioid receptor and somatostatin immunoreactivity characterize the RMTg, as do neurons projecting to the VTA/SNC that are enriched in GAD67 mRNA. Strong inputs to the RMTg arise in the lateral habenula (LHb) and, to a lesser extent, the SN. Other inputs come from the frontal cortex, ventral striatopallidum, extended amygdala, septum, preoptic region, lateral, paraventricular and posterior hypothalamus, zona incerta, periaqueductal gray, intermediate layers of the contralateral superior colliculus, dorsal raphe, mesencephalic, pontine and medullary reticular formation, and the following nuclei: parafascicular, supramammillary, mammillary, ventral lateral geniculate, deep mesencephalic, red, pedunculopontine and laterodorsal tegmental, cuneiform, parabrachial, and deep cerebellar. The RMTg has meager outputs to the forebrain, mainly to the ventral pallidum, preoptic-lateral hypothalamic continuum, and midline-intralaminar thalamus, but much heavier outputs to the brainstem, including, most prominently, the VTA/SNC, as noted above, and to medial tegmentum, pedunculopontine and laterodorsal tegmental nuclei, dorsal raphe, and locus ceruleus and subceruleus. The RMTg may integrate multiple forebrain and brainstem inputs in relation to a dominant LHb input. Its outputs to neuromodulatory projection systems likely converge with direct LHb projections to those structures.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“It was shown that the LHb has an inhibitory influence on dopaminergic neurons (Matsumoto and Hikosaka, 2007) via GABAergic interneurons in the rostromedial tegmental nucleus (Ji and Shepard, 2007; Jhou et al., 2009), which is reflected by the fact that lesioning of the habenula leads to an increase of cortical and striatal dopamine levels (Nishikawa et al., 1986).”
From Circuit Mechanisms of Reward, Anhedonia, and Depression (2019) · cites this paper as Jhou et al., 2009
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Brain stem reticular formation and activation of the EEG
Moruzzi, G., & Magoun, H. W. (1949) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(49)90219-9 · Cited by 4,307
Hypothalamic regulation of sleep and circadian rhythms
Saper, C. B., Scammell, T. E., & Lu, J. (2005) · Nature · doi:10.1038/nature04284 · Cited by 2,804
Large-scale neurocognitive networks and distributed processing for attention, language, and memory
Mesulam, M. (1990) · Annals of Neurology · doi:10.1002/ana.410280502 · Cited by 2,684
Aston-Jones, G., & Bloom, F. (1981) · The Journal of Neuroscience · doi:10.1523/jneurosci.01-08-00876.1981 · Cited by 1,960
Histochemical mapping of nitric oxide synthase in the rat brain
Vincent, S. R., & Kimura, H. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90184-4 · Cited by 1,868
Mapping Patterns of c- fos Expression in the Central Nervous System After Seizure
Morgan, J. I., Cohén, D., Hempstead, J. L., & Curran, T. (1987) · Science · doi:10.1126/science.3037702 · Cited by 1,786
Pan, L., Gurevich, E. V., & Gurevich, V. V. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209532200 · Cited by 1,758
Swanson, L. W. (1982) · Brain Research Bulletin · doi:10.1016/0361-9230(82)90145-9 · Cited by 1,718
Differential expression of orexin receptors 1 and 2 in the rat brain
Marcus, J. N., Aschkenasi, C. J., Lee, C. E., Chemelli, R. M., Saper, C. B., Yanagisawa, M., & Elmquist, J. K. (2001) · Journal of Comparative Neurology · doi:10.1002/cne.1190 · Cited by 1,659
The sleep switch: hypothalamic control of sleep and wakefulness
Saper, C. B., Chou, T. C., & Scammell, T. E. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)02002-6 · Cited by 1,656
Flagged first, then by citations
2 of the 102 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Heimer L, 2008, Anatomy of neuropsychiatry: the new anatomy of the basal forebrain and its implications for neuropsychiatric disease
- Jakab RL, 1995, The rat nervous system, 405
Cited by
Sorted by citations
Dopamine in motivational control: rewarding, aversive, and alerting
Bromberg-Martin, E. S., Matsumoto, M., & Hikosaka, O. (2010) · Neuron · doi:10.1016/j.neuron.2010.11.022 · Cited by 2,396
Input-specific control of reward and aversion in the ventral tegmental area
Lammel, S., Lim, B. K., Ran, C., Huang, K. W., Betley, M. J., Tye, K. M., Deisseroth, K., & Malenka, R. C. (2012) · Nature · doi:10.1038/nature11527 · Cited by 1,300
Mechanisms of ketamine action as an antidepressant
Zanos, P., & Gould, T. D. (2018) · Molecular Psychiatry · doi:10.1038/mp.2017.255 · Cited by 1,127
The habenula: from stress evasion to value-based decision-making
Hikosaka, O. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2866 · Cited by 955
Cortico-Basal Ganglia Reward Network: Microcircuitry
Sesack, S. R., & Grace, A. A. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.93 · Cited by 985
Jhou, T. C., Fields, H. L., Baxter, M. G., Saper, C. B., & Holland, P. C. (2009) · Neuron · doi:10.1016/j.neuron.2009.02.001 · Cited by 696
GABA Neurons of the VTA Drive Conditioned Place Aversion
Tan, K. R., Yvon, C., Turiault, M., Mirzabekov, J. J., Doehner, J., Labouèbe, G., Deisseroth, K. A., Tye, K. M., & Lüscher, C. (2012) · Neuron · doi:10.1016/j.neuron.2012.02.015 · Cited by 635
How Addictive Drugs Disrupt Presynaptic Dopamine Neurotransmission
Sulzer, D. (2011) · Neuron · doi:10.1016/j.neuron.2011.02.010 · Cited by 592
A Neural Circuit Mechanism for Encoding Aversive Stimuli in the Mesolimbic Dopamine System
de Jong, J. W., Afjei, S. A., Dorocic, I. P., Peck, J. R., Liu, C. J., Kim, C. K., Tian, L., Deisseroth, K. A., & Lammel, S. (2018) · Neuron · doi:10.1016/j.neuron.2018.11.005 · Cited by 525
Circuits and functions of the lateral habenula in health and in disease
Hu, H., Cui, Y., & Yang, Y. (2020) · Nature reviews. Neuroscience · doi:10.1038/s41583-020-0292-4 · Cited by 489
Brain reward circuitry beyond the mesolimbic dopamine system: a neurobiological theory
Ikemoto, S. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.02.001 · Cited by 454
Hong, S., Jhou, T. C., Smith, M., Saleem, K. S., & Hikosaka, O. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.1384-11.2011 · Cited by 390
Reward, addiction, withdrawal to nicotine
De Biasi, M., & Dani, J. A. (2011) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-061010-113734 · Cited by 366
“As in the LHb, RMTg neurons are phasically activated by aversive stimuli and inhibited by natural rewards such as food or reward-predictive stimuli, and conversely, RMTg neurons are stimulated by aversive stimuli (Jhou et al. 2009b).”
BackgroundStamatakis, A. M., Jennings, J. H., Ung, R. L., Blair, G. A., Weinberg, R. J., Neve, R. L., Boyce, F., Mattis, J., Ramakrishnan, C., Deisseroth, K., et al. (2013) · Neuron · doi:10.1016/j.neuron.2013.08.023 · Cited by 364
The ventral pallidum: Subregion-specific functional anatomy and roles in motivated behaviors
Root, D. H., Meléndez, R. I., Záborszky, L., & Napier, T. C. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.03.005 · Cited by 359
Dopamine neurons projecting to the posterior striatum form an anatomically distinct subclass
Menegas, W., Bergan, J. F., Ogawa, S. K., Isogai, Y., Venkataraju, K. U., Osten, P., Uchida, N., & Watabe‐Uchida, M. (2015) · eLife · doi:10.7554/elife.10032 · Cited by 335
Neuronal circuits underlying acute morphine action on dopamine neurons
Jalabert, M., Bourdy, R., Courtin, J., Veinante, P., Manzoni, O. J., Barrot, M., & Georges, F. E. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1105418108 · Cited by 302
Molecular characterization of the subnuclei in rat habenula
Aizawa, H., Kobayashi, M. S., Tanaka, S., Fukai, T., & Okamoto, H. (2012) · The Journal of Comparative Neurology · doi:10.1002/cne.23167 · Cited by 288
Lateral habenula in the pathophysiology of depression
Yang, Y., Wang, H., Hu, J., & Hu, H. (2018) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.10.024 · Cited by 254
Hu, H. (2016) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-070815-014106 · Cited by 253
Circuit Mechanisms of Reward, Anhedonia, and Depression
Höflich, A., Michenthaler, P., Kasper, S., & Lanzenberger, R. (2019) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyy081 · Cited by 253
Lateral habenula projections to dopamine and GABA neurons in the rat ventral tegmental area
Omelchenko, N., Bell, R., & Sesack, S. R. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06924.x · Cited by 263
Brinschwitz, K., Dittgen, A., Madai, V. I., Lommel, R., Geisler, S., & Veh, R. W. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.03.050 · Cited by 240
Identification of the Zebrafish Ventral Habenula As a Homolog of the Mammalian Lateral Habenula
Amo, R., Aizawa, H., Takahoko, M., Kobayashi, M. S., Takahashi, R., Aoki, T., & Okamoto, H. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3690-09.2010 · Cited by 236
Topographical Organization of the Pedunculopontine Nucleus
Martinez‐Gonzalez, C., Bolam, J. P., & Mena‐Segovia, J. (2011) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2011.00022 · Cited by 240
Matsui, A., Jarvie, B. C., Robinson, B. G., Hentges, S. T., & Williams, J. T. (2014) · Neuron · doi:10.1016/j.neuron.2014.04.030 · Cited by 237
Balcita‐Pedicino, J. J., Omelchenko, N., Bell, R., & Sesack, S. R. (2010) · The Journal of Comparative Neurology · doi:10.1002/cne.22561 · Cited by 246
Basal ganglia circuit loops, dopamine and motivation: a review and enquiry
Ikemoto, S., Yang, C., & Tan, A. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.04.018 · Cited by 226
Distributed and Mixed Information in Monosynaptic Inputs to Dopamine Neurons
Tian, J., Huang, R., Cohen, J. Y., Osakada, F., Kobak, D., Machens, C. K., Callaway, E. M., Uchida, N., & Watabe-Uchida, M. (2016) · Neuron · doi:10.1016/j.neuron.2016.08.018 · Cited by 224
VTA GABA Neurons at the Interface of Stress and Reward
Bouarab, C., Thompson, B. V., & Polter, A. M. (2019) · Frontiers in Neural Circuits · doi:10.3389/fncir.2019.00078 · Cited by 233
Braking Dopamine Systems: A New GABA Master Structure for Mesolimbic and Nigrostriatal Functions
Barrot, M., Sesack, S. R., Georges, F. E., Pistis, M., Hong, S., & Jhou, T. C. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.3370-12.2012 · Cited by 229
Amo, R., Fredes, F., Kinoshita, M., Aoki, R., Aizawa, H., Agetsuma, M., Aoki, T., Shiraki, T., Kakinuma, H., Matsuda, M., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.10.035 · Cited by 217
A new control center for dopaminergic systems: pulling the VTA by the tail
Bourdy, R., & Barrot, M. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.06.007 · Cited by 222
GABAergic and glutamatergic efferents of the mouse ventral tegmental area
Taylor, S. R., Badurek, S., Dileone, R., Nashmi, R., Minichiello, L., & Picciotto, M. R. (2014) · The Journal of Comparative Neurology · doi:10.1002/cne.23603 · Cited by 226
Sustained antidepressant effect of ketamine through NMDAR trapping in the LHb
Ma, S., Chen, M., Jiang, Y., Xiang, X., Wang, S., Wu, Z., Li, S., Cui, Y., Wang, J., Zhu, Y., et al. (2023) · Nature · doi:10.1038/s41586-023-06624-1 · Cited by 227
Dopamine and extinction: A convergence of theory with fear and reward circuitry
Abraham, A. D., Neve, K. A., & Lattal, K. M. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.11.007 · Cited by 214
Jhou, T. C., Good, C. H., Rowley, C. S., Xu, S., Wang, H., Burnham, N. W., Hoffman, A. F., Lupica, C. R., & Ikemoto, S. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3634-12.2013 · Cited by 211
Identification of Rat Ventral Tegmental Area GABAergic Neurons
Margolis, E. B., Toy, B. C., Himmels, P., Morales, M., & Fields, H. L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042365 · Cited by 215
Matsui, A., & Williams, J. T. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.4570-11.2011 · Cited by 191
Genetic dissection of medial habenula–interpeduncular nucleus pathway function in mice
Kobayashi, Y., Sano, Y., Vannoni, E., Goto, H., Suzuki, H., Oba, A., Kawasaki, H., Kanba, S., Lipp, H., Murphy, N. P., et al. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00017 · Cited by 195
Lecca, S., Melis, M., Luchicchi, A., Muntoni, A. L., & Pistis, M. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.302 · Cited by 185
An Update on the Role of Serotonin and its Interplay with Dopamine for Reward
Fischer, A. G., & Ullsperger, M. (2017) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2017.00484 · Cited by 189
Stephenson‐Jones, M., Floros, O., Robertson, B., & Grillner, S. E. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1119348109 · Cited by 178
An update on the connections of the ventral mesencephalic dopaminergic complex
Yetnikoff, L., Lavezzi, H. N., Reichard, R. A., & Zahm, D. S. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.04.010 · Cited by 189
Efferent Pathways of the Mouse Lateral Habenula
Quina, L. A., Tempest, L., Ng, L., Harris, J. A., Ferguson, S. M., Jhou, T. C., & Turner, E. E. (2014) · The Journal of Comparative Neurology · doi:10.1002/cne.23662 · Cited by 177
Translating the habenula-from rodents to humans
Boulos, L.-J., Darcq, E., & Kieffer, B. L. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.06.003 · Cited by 164
Transcriptional and spatial resolution of cell types in the mammalian habenula
Hashikawa, Y., Hashikawa, K., Rossi, M. A., Basiri, M. L., Liu, Y., Johnston, N. L., Ahmad, O. R., & Stuber, G. D. (2020) · Neuron · doi:10.1016/j.neuron.2020.03.011 · Cited by 167
The Neural Circuits Underlying General Anesthesia and Sleep
Moody, O. A., Zhang, E. R., Vincent, K. F., Kato, R., Melonakos, E. D., Nehs, C. J., & Solt, K. (2021) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000005361 · Cited by 176
Deurwaerdère, P. D., & Giovanni, G. D. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.03.004 · Cited by 170
The Lateral Habenula Circuitry: Reward Processing and Cognitive Control
Baker, P. M., Jhou, T. C., Li, B., Matsumoto, M., Mizumori, S. J. Y., Stephenson‐Jones, M., & Vicentic, A. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.2350-16.2016 · Cited by 164
Generating bursts (and pauses) in the dopamine midbrain neurons
Paladini, C. A., & Roeper, J. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.07.032 · Cited by 167
Lecca, S., Melis, M., Luchicchi, A., Ennas, M. G., Castelli, M. P., Muntoni, A. L., & Pistis, M. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.190 · Cited by 158
Behavioral and neurobiological mechanisms of punishment: implications for psychiatric disorders
Jean-Richard-Dit-Bressel, P., Killcross, S., & McNally, G. P. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0047-3 · Cited by 160
Flagel, S. B., Cameron, C., Pickup, K. N., Watson, S. J., Akil, H., & Robinson, T. E. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.09.004 · Cited by 153
The role of the habenula in drug addiction
Velasquez, K. M., Molfese, D. L., & Salas, R. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00174 · Cited by 155
Morikawa, H., & Paladini, C. A. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.08.023 · Cited by 159
Mechanisms of Action and Persistent Neuroplasticity by Drugs of Abuse
Korpi, E. R., den Hollander, B., Farooq, U., Vashchinkina, E., Rajkumar, R., Nutt, D. J., Hyytiä, P., & Dawe, G. S. (2015) · Pharmacological Reviews · doi:10.1124/pr.115.010967 · Cited by 148
Zhao, H., Zhang, B., Yang, S., & Rusak, B. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.09.016 · Cited by 147
Okamoto, H., Agetsuma, M., & Aizawa, H. (2011) · Developmental Neurobiology · doi:10.1002/dneu.20913 · Cited by 142
Mahler, S. V., & Aston‐Jones, G. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2277-12.2012 · Cited by 150
Ethanol Action on Dopaminergic Neurons in the Ventral Tegmental Area
Morikawa, H., & Morrisett, R. A. (2010) · International review of neurobiology · doi:10.1016/s0074-7742(10)91008-8 · Cited by 146
Glial Dysfunction in the Mouse Habenula Causes Depressive-Like Behaviors and Sleep Disturbance
Cui, W., Mizukami, H., Yanagisawa, M., Aida, T., Nomura, M., Isomura, Y., Takayanagi, R., Ozawa, K., Tanaka, K., & Aizawa, H. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.1465-14.2014 · Cited by 139
Kim, U., & Lee, T. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2012.08030.x · Cited by 133
Overriding Phasic Dopamine Signals Redirects Action Selection during Risk/Reward Decision Making
Stopper, C. M., Tse, M. T. L., Montes, D. R., Wiedman, C. R., & Floresco, S. B. (2014) · Neuron · doi:10.1016/j.neuron.2014.08.033 · Cited by 136
Gonçalves, L., Sego, C., & Metzger, M. (2011) · The Journal of Comparative Neurology · doi:10.1002/cne.22787 · Cited by 134
The medial habenula: still neglected
Viswanath, H., Carter, A. Q., Baldwin, P. R., Molfese, D. L., & Salas, R. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00931 · Cited by 142
What's better for me? Fundamental role for lateral habenula in promoting subjective decision biases
Stopper, C. M., & Floresco, S. (2013) · Nature Neuroscience · doi:10.1038/nn.3587 · Cited by 138
Liang, K. J., & Carlson, E. S. (2019) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2019.01.004 · Cited by 131
Optogenetic dissection of neural circuits underlying emotional valence and motivated behaviors
Nieh, E. H., Kim, S., Namburi, P., & Tye, K. M. (2012) · Brain Research · doi:10.1016/j.brainres.2012.11.001 · Cited by 139
α1-Adrenergic Receptors in Neurotransmission, Synaptic Plasticity, and Cognition
Perez, D. M. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.581098 · Cited by 139
Chartoff, E. H., & Connery, H. S. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00116 · Cited by 136
Kokane, S. S., & Perrotti, L. I. (2020) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2020.00074 · Cited by 132
Sego, C., Gonçalves, L., Lima, L. B., Furigo, I. C., Donato, J., & Metzger, M. (2013) · The Journal of Comparative Neurology · doi:10.1002/cne.23533 · Cited by 132
Defining the habenula in human neuroimaging studies
Lawson, R. P., Drevets, W. C., & Roiser, J. P. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.08.076 · Cited by 127
Ikemoto, S., & Bonci, A. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.04.031 · Cited by 129
The Evolving Understanding of Dopamine Neurons in the Substantia Nigra and Ventral Tegmental Area
Gantz, S. C., Ford, C., Morikawa, H., & Williams, J. T. (2017) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021317-121615 · Cited by 126
Phylogeny and Ontogeny of the Habenular Structure
eAizawa, H., Amo, R., & Okamoto, H. (2011) · Frontiers in Neuroscience · doi:10.3389/fnins.2011.00138 · Cited by 119
Neurobiological Mechanisms of Nicotine Reward and Aversion
Wills, L. P., Ables, J. L., Braunscheidel, K. M., Caligiuri, S. P. B., Elayouby, K. S., Fillinger, C., Ishikawa, M., Moen, J. K., & Kenny, P. J. (2022) · Pharmacological Reviews · doi:10.1124/pharmrev.121.000299 · Cited by 134
Hahn, J. D., & Swanson, L. W. (2010) · Brain Research Reviews · doi:10.1016/j.brainresrev.2010.02.002 · Cited by 123
Functional Dissection of Basal Ganglia Inhibitory Inputs onto Substantia Nigra Dopaminergic Neurons
Evans, R. C., Twedell, E. L., Zhu, M., Ascencio, J., Zhang, R., & Khaliq, Z. M. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108156 · Cited by 110
Wang, D. V., & Tsien, J. Z. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017047 · Cited by 116
Circadian oscillators in the epithalamus
Guilding, C., Hughes, A. T. L., & Piggins, H. D. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.06.015 · Cited by 112
Bourdy, R., Sánchez-Catalán, M. J., Kaufling, J., Balcita‐Pedicino, J. J., Freund‐Mercier, M. J., Veinante, P., Sesack, S. R., Georges, F. E., & Barrot, M. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.129 · Cited by 113
The antero-posterior heterogeneity of the ventral tegmental area
Sánchez-Catalán, M. J., Kaufling, J., Georges, F. E., Veinante, P., & Barrot, M. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.09.025 · Cited by 118
Optogenetic Modulation of Neural Circuits that Underlie Reward Seeking
Stuber, G. D., Britt, J. P., & Bonci, A. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.11.010 · Cited by 124
Excitatory pathways from the lateral habenula enable propofol-induced sedation
Gelegen, C., Miracca, G., Ran, M. Z., Harding, E. C., Ye, Z., Yu, X., Tossell, K., Houston, C. M., Yustos, R., Hawkins, E. D., et al. (2018) · Current Biology · doi:10.1016/j.cub.2017.12.050 · Cited by 100
Opioid Modulation of Ventral Pallidal Afferents to Ventral Tegmental Area Neurons
Hjelmstad, G. O., Xia, Y., Margolis, E. B., & Fields, H. L. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0178-13.2013 · Cited by 106
Yetnikoff, L., Cheng, A. Y., Lavezzi, H. N., Parsley, K. P., & Zahm, D. S. (2015) · Journal of Comparative Neurology · doi:10.1002/cne.23797 · Cited by 101
Bernard, R., & Veh, R. W. (2012) · The Journal of Comparative Neurology · doi:10.1002/cne.23080 · Cited by 103
The role of the habenula in the transition from reward to misery in substance use and mood disorders
Batalla, A., Homberg, J. R., Lipina, T. V., Sescousse, G., Luijten, M., Ivanova, S. А., Schellekens, A., & LOONEN, A. J. M. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.03.019 · Cited by 101
Gardon, O., Faget, L. C., Chung, P. C. S., Matifas, A., Massotte, D., & Kieffer, B. L. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.07.053 · Cited by 105
Kawai, T., Yamada, H., Sato, N., Takada, M., & Matsumoto, M. (2015) · Neuron · doi:10.1016/j.neuron.2015.09.030 · Cited by 108
Anxiety and Nicotine Dependence: Emerging Role of the Habenulo-Interpeduncular Axis
Molas, S., DeGroot, S. R., Zhao-Shea, R., & Tapper, A. R. (2016) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2016.11.001 · Cited by 109
Progress in understanding mood disorders: optogenetic dissection of neural circuits
Lammel, S., Tye, K. M., & Warden, M. R. (2014) · Genes, Brain and Behavior · doi:10.1111/gbb.12049 · Cited by 98
Multiplexed neurochemical signaling by neurons of the ventral tegmental area
Barker, D. J., Root, D. H., Zhang, S., & Morales, M. (2016) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2015.12.016 · Cited by 105
Tsutsui‐Kimura, I., Matsumoto, H., Akiti, K., Yamada, M. M., Uchida, N., & Watabe‐Uchida, M. (2020) · eLife · doi:10.7554/elife.62390 · Cited by 92
Turning a Negative into a Positive: Ascending GABAergic Control of Cortical Activation and Arousal
Brown, R. E., & McKenna, J. T. (2015) · Frontiers in Neurology · doi:10.3389/fneur.2015.00135 · Cited by 95
Error-Related Functional Connectivity of the Habenula in Humans
Ide, J. S., & Li, C. R. (2011) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2011.00025 · Cited by 90
Cocaine Evokes Projection-Specific Synaptic Plasticity of Lateral Habenula Neurons
Maroteaux, M. J., & Mameli, M. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2405-12.2012 · Cited by 99
Reward Prediction Error Coding in Dorsal Striatal Neurons
Oyama, K., Hernádi, I., Iijima, T., & Tsutsui, K. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1719-10.2010 · Cited by 91
Metadata
- Authors
- Jhou, T. C., Geisler, S., Marinelli, M., Degarmo, B. A., & Zahm, D. S.
- Affiliations
- National Institutes of Health (US)
- Saint Louis University (US)
- Rosalind Franklin University of Medicine and Science (US)
- Corresponding author
- Jhou, Thomas C.
- Zahm, Daniel S.
- Venue
- Journal of Comparative Neurology
- Publisher
- Wiley
- Published
- 2009-02-20
- Volume
- 513
- Issue
- 6
- Pages
- 566-596
- ISSN
- 0021-9967 (ISSN-L)
- 1096-9861
- PMC
- PMC3116663
- OpenAlex
- W2085520758
- Cited by
- 503
- References
- 102
- Citations by year
- 2026: 16 · 2025: 15 · 2024: 35 · 2023: 13 · 2022: 17 · 2021: 39 · 2020: 48 · 2019: 39 · 2018: 34 · 2017: 27 · 2016: 34 · 2015: 26 · 2014: 38 · 2013: 36 · 2012: 28
- FWCI
- 11.61
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Journal of Comparative Neurology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL 60292, P50HL060292)
- National Institute of Mental Health (MH-12370, F31MH012370)
- National Institute on Drug Abuse (DA020654, R01DA020654)
- National Institute of Neurological Disorders and Stroke (NS23805, R01NS023805)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
- Keywords
- rostromedial tegmental nucleus, lateral habenula, ventral tegmental area, substantia nigra pars compacta, mesopontine tegmentum, interpeduncular nucleus, Fos expression, aversive stimuli, psychostimulants, mu-opioid receptor, somatostatin, GAD67, neuroanatomy, brainstem projections, neuromodulation, pedunculopontine nucleus, laterodorsal tegmentum, dorsal raphe nucleus, locus coeruleus
- MeSH terms
- Animals, Cocaine, Glutamate Decarboxylase, Male, Methamphetamine, Neural Pathways, RNA, Messenger, Self Administration, Somatostatin, Substantia Nigra, Sulfur Radioisotopes, Tegmentum Mesencephali, Gene Expression, Proto-Oncogene Proteins c-fos, Rats, Sprague-Dawley, Receptors, Opioid, mu, Ventral Tegmental Area, Habenula, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
