Dendritic synthesis and release of the neuropeptide galanin: morphological evidence from studies on rat locus coeruleus neurons
Abstract
Dendritic synthesis and release of neuropeptides have been demonstrated in hypothalamic neurosecretory neurons. Here we tested whether this mechanism may be applicable to galanin in rat locus coeruleus (LC) neurons. Light and electron microscopic immunocytochemistry demonstrated the occurrence of galanin peptide in secretory granules within dendritic processes. In situ hybridization at the light and electron microscopic level showed galanin mRNA in these LC processes. Moreover, the levels of the transcript and its extension into the dendrites were significantly increased by reserpine treatment. Finally, evidence for exocytotic release from large dense-core vesicles in LC dendrites was obtained by using tannic acid-treated slices. Taken together, these results indicate that galanin can be synthesized in, and possibly released from, LC. These data support a key function of the neuropeptide galanin as an auto-paracrine local modulator in a major, strongly divergent monoaminergic regulatory system.
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Most cortical glutamatergic neurons have locally ramifying axon branches and may secrete neuropeptides from their local dendritic arbors.
“Even so, most cortical glutamatergic neurons also have locally ramifying axon branches and may also secrete neuropeptides from their local dendritic arbors (Vila-Porcile et al., 2009).”
From Single-cell transcriptomic evidence for dense intracortical neuropeptide networks (2019) · cites this paper as Vila-Porcile et al., 2009
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Single-cell transcriptomic evidence for dense intracortical neuropeptide networks
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- Authors
- Vila‐Porcile, É., Xu, Z. D., Mailly, P., Nagy, F., Calas, A., Hökfelt, T., & Landry, M.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Université de Bordeaux (FR)
- Karolinska Institutet (SE)
- Corresponding author
- Landry, Marc
- Venue
- Journal of Comparative Neurology
- Publisher
- Wiley
- Published
- 2009-07-14
- Volume
- 516
- Issue
- 3
- Pages
- 199-212
- ISSN
- 0021-9967 (ISSN-L)
- 1096-9861
- OpenAlex
- W1987715362
- Cited by
- 37
- References
- 94
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 4 · 2020: 1 · 2019: 3 · 2018: 3 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 1 · 2012: 2
- FWCI
- 1.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Comparative Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- galanin, neuropeptide biosynthesis, dendritic release, locus coeruleus, secretory granules, reserpine, dense core vesicles, exocytosis, monoaminergic neurons, rats
- MeSH terms
- Animals, Central Nervous System Agents, Dendrites, Exocytosis, Locus Coeruleus, Male, Neurons, Protein Precursors, Reserpine, RNA, Messenger, Tannins, Rats, Sprague-Dawley, Galanin, Secretory Vesicles, Rats, In Vitro Techniques
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