Dendrites of hypothalamic magnocellular neurons release neurohypophysial peptides by exocytosis

Pow, D.V.; Morris, J.F.

doi:10.1016/0306-4522(89)90091-2

Cited by 451Cellular transport and secretionNeuroendocrine regulation and behaviorNeuroscience and Neuropharmacology Research

Dendrites of hypothalamic magnocellular neurons release neurohypophysial peptides by exocytosis

Pow, D.V., Morris, J.F.·1989·Neuroscience

DOI 10.1016/0306-4522(89)90091-2

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Abstract

Exocytosis of neurosecretory granules from dendrites of magnocellular neurons can be visualized electron microscopically after incubation of hypothalamic brain slices in media containing 1.2 mM tannic acid, which stabilizes extracellular peptidergic granule cores, and permits their immunocytochemical identification. Morphometric analysis of stimulated slices demonstrates that exocytosis of neurosecretory granules from the dendrites of magnocellular neurons can account for the vasopressin and oxytocin known to be released into the hypothalamus. Exocytosis from cell bodies of magnocellular neurons was not observed in stimulated slices from normal rats but, when granules had been caused to accumulate in the neuronal somata by prior administration of colchicine, exocytosis of granules from the somata was unambiguously identified. These data demonstrate exocytosis from dendrites and cell bodies of a mammalian peptidergic neuron, and show that all parts of their plasmalemma are competent for exocytosis of granules.

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Authors: Pow, D. V., & Morris, J. F.
Affiliations: University of Oxford (GB)
ORCID: Pow, D.V.
Morris, J.F.
Venue: Neuroscience
Publisher: Elsevier BV
Published: 1989-01
Volume: 32
Issue: 2
Pages: 435-439
ISSN: 0306-4522 (ISSN-L)
DOI: 10.1016/0306-4522(89)90091-2
OpenAlex: W1978044599
Cited by: 446
References: 30
Citations by year: 2026: 5 · 2025: 2 · 2024: 5 · 2023: 10 · 2022: 10 · 2021: 8 · 2020: 13 · 2019: 10 · 2018: 9 · 2017: 10 · 2016: 15 · 2015: 16 · 2014: 12 · 2013: 11 · 2012: 7
FWCI: 3.92
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: exocytosis, dendrites, magnocellular neurons, hypothalamus, neurosecretory granules, vasopressin, oxytocin, neurohypophyseal peptides, tannic acid, colchicine, neuronal somata, peptidergic neurons
MeSH terms: Animals, Cytoplasmic Granules, Dendrites, Exocytosis, Male, Oxytocin, Supraoptic Nucleus, Vasopressins, Rats

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Dendrites of hypothalamic magnocellular neurons release neurohypophysial peptides by exocytosis

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