Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 1,273

The DOI matches its Crossref record.

A retinohypothalamic projection in the rat

Moore, Robert Y., Lenn, Nicholas J.·1972·Journal of Comparative Neurology
DOI 10.1002/cne.901460102
Open this paper in CoChat — free account

Abstract

A direct projection from the retina to the hypothalamus was demonstrated in the rat. Following injection of tritiated leucine or proline into the posterior chamber of the eye, labelled protein was shown autoradiographically in the suprachiasmatic nuclei of the medial hypothalamus, both ipsilateral and contralateral to the injected eye. The labelling of the nucleus was heaviest in its ventral portion but extended throughout the nucleus. No evidence for a projection to the supraoptic nucleus or any other hypothalamic nucleus was observed. All of the known terminal nuclei of the primary and accessory optic tracts were heavily labelled. The projection to the suprachiasmatic nucleus could not be clearly confirmed in material prepared using the Fink‐Heimer method for the demonstration of degenerating axon terminals. Electron microscopic study of the suprachiasmatic nucleus following orbital enucleation showed degenerating endings making synaptic contacts with small dendrites of the suprachiasmatic nucleus cells. These first appeared at three days after operation and were nearly gone by seven days. Thus, the retinohypothalamic tract in the rat appears to arise from the ganglion cells of the retina and to terminate on the smaller dendritic branches of the neurons of the suprachiasmatic nucleus.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1002/cne.901460102

Cites

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 58

  1. 10.1007/BF00384334 · doi:10.1007/bf00384334
  2. 10.1002/cne.900660106 · doi:10.1002/cne.900660106
  3. Bons N., 1969, Presence de fibres retiniennes degenerees dans la region hypothalamique supra‐optique du Canard apres section d'un nerf optique, C. R. Acad. Sci. (Paris), 269, 1535
  4. Butler J. E. M., 1971, The effects of surgical isolation of the hypothalamus on reproductive function in the female rat, J. Endocrin., 49, 293, 10.1677/joe.0.0490293 · doi:10.1677/joe.0.0490293
  5. 10.1111/j.1749-6632.1969.tb20458.x · doi:10.1111/j.1749-6632.1969.tb20458.x
  6. 10.1002/cne.901430108 · doi:10.1002/cne.901430108
  7. 10.1002/cne.901310205 · doi:10.1002/cne.901310205
  8. 10.1002/cne.901360403 · DOI
  9. Critchlow V., 1963, Advances in Neuroendocrinology, 377
  10. 10.1159/000125500 · DOI
  11. 10.1159/000125470 · DOI
  12. 10.1016/0006-8993(68)90171-6 · DOI
  13. Frey E., 1937, Vergleichend‐anatomische Untersuchungen über die basale optische Wurzel, die Commissura transversa Gudden und über eine Verbindung der Netzhaut mit dem vegetativen Gebiet im Hypothalamus durch eine "dorsale hypothalamische Wurzel" des Nervus opticus bei Amnioten, Schweiz. Arch. Neur. Psychiat., 39, 255
  14. 10.1159/000140279 · doi:10.1159/000140279
  15. Frey E., 1950, Neue anatomische und experimentelle Ergebuisse über das optische Gebiet im Hypothalamus, Schweiz. Arch. Neur. Psychiat., 66, 67
  16. Frey E., 1951, Über die Hypothalamische Opticuswurzel des Hundes, Bull. Schweiz. Akad. Med., 7, 115
  17. 10.1016/0006-8993(67)90166-7 · DOI · Paper page
  18. Garey L. J., 1968, The projection of the retina in the cat, J. Anat. (Lond.), 102, 189
  19. 10.1002/cne.901210108 · DOI
  20. 10.1126/science.157.3785.196 · DOI
  21. Grafstein B., 1969, Advances in Biochemical Psychopharmacology, 11
  22. 10.1126/science.172.3979.177 · DOI · Paper page
  23. Harris G. W., 1955, Neural Control of the Pituitary, 60
  24. Hayhow W. R., 1966, The accessory optic system in the marsupial phalanger, Trichosurus vulpeca, J. Comp. Neur., 126, 653
  25. 10.1002/cne.901180303 · DOI · Paper page
  26. 10.1002/cne.901150207 · doi:10.1002/cne.901150207
  27. 10.1126/science.165.3889.194 · doi:10.1126/science.165.3889.194
  28. 10.1002/cne.900770202 · doi:10.1002/cne.900770202
  29. 10.1111/j.1471-4159.1971.tb12005.x · doi:10.1111/j.1471-4159.1971.tb12005.x
  30. 10.1002/cne.901310310 · doi:10.1002/cne.901310310
  31. 10.1111/j.1600-0404.1965.tb04304.x · doi:10.1111/j.1600-0404.1965.tb04304.x
  32. Knoche H., 1956, Morphologisch‐experimentelle Untersuchungen über eine Faserverhindung der Retina mit den vegetativen Zentren des Zwischenhirns und mit der Hypophyse, Z. Zellforsch., 45, 201, 10.1007/BF00338831 · doi:10.1007/bf00338831
  33. Knoche H., 1957, Die retino‐hypothalamische Bahn von Mensch, Hund und Kaninchen, Z Mikeranta. Forsch., 63, 461
  34. 10.1007/BF00334922 · doi:10.1007/bf00334922
  35. 10.1177/10.3.269 · DOI · Paper page
  36. 10.1016/0006-8993(71)90645-7 · doi:10.1016/0006-8993(71)90645-7
  37. 10.1016/0006-8993(68)90052-8 · DOI · Paper page
  38. 10.1113/jphysiol.1956.sp005493 · DOI · Paper page
  39. Moore R. Y., 1969, Progress in Endocrinology, 490
  40. Moore R. Y., 1972, Proceedings of a Workshop on the Pineal Gland
  41. Moore R. Y., 1971, A retinohypothalamic projection in the rat, Anat. Rec., 169, 382
  42. Nauta W. J. H., 1969, The Hypothalamus, 187
  43. 10.1016/0006-8993(68)90185-6 · DOI
  44. Palay S. L., 1958, The morphology of synapses in the central nervous system, Exptl. Cell Res., Suppl., 5, 275
  45. Pate J. R., 1937, Trans‐neural atrophy of the nucleus ovoidens following eye removal in cats, Anat. Rec., 67, 39
  46. Polyak S., 1957, The Vertebrate Visual System
  47. Price J. L., 1971, Autoradiographic demonstration of pathways in the mammalian CNS, Anat. Rec., 169, 406
  48. Rieke W. O., 1958, Optico‐hypothalamic pathways in the rat, Anat. Rec., 130, 363
  49. 10.1002/cne.901210104 · DOI
  50. Roussy G., 1935, L'hypothalamus chez l'homme et chez le Chien, Rev. Neurol. (Paris), 63, 1
  51. 10.1007/BF00237920 · doi:10.1007/bf00237920
  52. 10.1111/j.1471-4159.1969.tb08971.x · DOI
  53. Sousa‐Pinto A., 1970, Electron microscopic observations on the possible retinohypothalamic projection in the rat, Exp. Brain Res., 11, 528
  54. Sousa‐Pinto A., 1970, Light microscopic observations on the possible retinohypothalamic projection in the rat, Exp. Brain Res., 11, 515
  55. Szentagothai J., 1968, Hypothalamic Control of the Anterior Pituitary
  56. 10.1073/pnas.54.6.1521 · DOI
  57. Tigges J., 1966, Ein experimenteller Beitrag zum subkortikalen optischen System von Tupaia glis, Folia Primat., 4, 102, 10.1159/000155047 · doi:10.1159/000155047
  58. 10.1016/B978-1-4832-3229-4.50009-9 · DOI

Cited by

See all 1,273

Metadata

Authors
Moore, R. Y., & Lenn, N. J.
Venue
Journal of Comparative Neurology
Publisher
Wiley
Published
1972-09
Volume
146
Issue
1
Pages
1-14
ISSN
  • 0021-9967 (ISSN-L)
  • 1096-9861
DOI
10.1002/cne.901460102
OpenAlex
W2047678578
Cited by
1,273
References
0
FWCI
13.95
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 11726 d)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: A retinohypothalamic projection in the rat. https://app.cochat.ai/papers/10.1002/cne.901460102
The paper
Moore, R. Y., & Lenn, N. J. (1972). A retinohypothalamic projection in the rat. Journal of Comparative Neurology. https://doi.org/10.1002/cne.901460102

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.