Subcortical afferents to the hippocampal formation in the monkey
Abstract
The distribution of neurons in the basal telencephalon, the diencephalon, and the brainstem that project to the hippocampal formation has been analyzed in mature cynomolgus monkeys (Macaca fascicularis) by the injection of horseradish peroxidase into different rostro‐caudal levels of the hippocampal formation. After injections which involve Ammon's horn, the dentate gyrus, and the subicular complex, retrogradely labeled neurons are found in the following regions: in the amygdala (specifically in the anterior amygdaloid area, the basolateral nucleus, and the periamygdaloid cortex); in the medial septal nucleus and the nucleus of the diagonal band; in the ventral part of the claustrum; in the substantia innominata and the basal nucleus of Meynert; in the rostral thalamus (specifically in the anterior nuclear complex, the laterodorsal nucleus, the paraventricular and parataenial nuclei, the nucleus reuniens, and the nucleus centralis medialis); in the lateral preoptic and lateral hypothalamic areas, and especially in the supramammillary and retromammillary regions; in the ventral tegmental area, the tegmental reticular fields, the raphé nuclei (specifically in nucleus centralis superior and the dorsal raphé nucleus), in the nucleus reticularis tegmenti pontis, the central gray, the dorsal tegmental nucleus, and in the locus coeruleus.
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The thalamus is crucial to the integration of sensory information in the cortex, amygdala, and hippocampus.
“Indeed, the thalamus is crucial to the integration of sensory information in the cortex, amygdala, and hippocampus (Amaral and Cowan, 1980;Kandel et al., 2000;Krystal et al., 1998;McCormick, 1992;Turner and Herkenham, 1991).”
From A review of the relation between dissociation, memory, executive functioning and social cognition in military members and civilians with neuropsychiatric conditions (2016) · cites this paper as Amaral and Cowan, 1980
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“There is also a light cingulum projection from the anterior thalamic nuclei to the hippocampal formation (Amaral and Cowan, 1980).”
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“Indeed, the thalamus is crucial to the integration of sensory information in the cortex, amygdala, and M.C. McKinnon et al. / Neuropsychologia 90 (2016) 210–234222 hippocampus (Amaral and Cowan, 1980; Kandel et al., 2000; Krystal et al., 1998; McCormick, 1992; Turner and Herkenham, 1991).”
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- Authors
- Amaral, D. G., & Cowan, W. M.
- Affiliations
- Washington University in St. Louis (US)
- ORCID
- Amaral, David G.
- Venue
- Journal of Comparative Neurology
- Publisher
- Wiley
- Published
- 1980-02-15
- Volume
- 189
- Issue
- 4
- Pages
- 573-591
- ISSN
- 0021-9967 (ISSN-L)
- 1096-9861
- OpenAlex
- W1966207574
- Cited by
- 390
- References
- 1
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 6 · 2023: 10 · 2022: 5 · 2021: 10 · 2020: 9 · 2019: 10 · 2018: 10 · 2017: 10 · 2016: 8 · 2015: 7 · 2014: 10 · 2013: 9 · 2012: 9
- FWCI
- 7.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Comparative Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- hippocampal formation, projection neurons, Macaca fascicularis, amygdala, medial septum, diagonal band of Brodmann, thalamus, ventral tegmental area, raphe nuclei, locus coeruleus, basal telencephalon, diencephalon, brainstem, retrograde tracing, Ammon's horn, dentate gyrus, subiculum
- MeSH terms
- Afferent Pathways, Amygdala, Animals, Haplorhini, Basal Ganglia, Brain Mapping, Brain Stem, Hippocampus, Hypothalamus, Macaca fascicularis, Septal Nuclei, Thalamic Nuclei
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