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Calcium-binding protein (calbindin-D28K) and parvalbumin immunocytochemistry in the normal and epileptic human hippocampus.

Sloviter, Robert S., Sollas, Anne L., Barbaro, Nicholas M., Laxer, Kenneth D.·1991·Journal of Comparative Neurology

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Abstract

The calcium‐binding proteins calbindin‐D28K (CaBP) and parvalbumin (PV) were localized in the “normal” and “epileptic” human hippocampus to address the possible relationship between the expression of these constitutive cytosolic calcium‐binding proteins and the resistance or selective vulnerability of different hippocampal neuron populations in temporal lobe epilepsy. Compared to rodents and a baboon ( Papio papio ), the pattern of CaBP‐like immunoreactivity (LI) in the “normal” human hippocampus is unique. CaBP‐LI is present in the dentate granule cells, neurons of the “resistant zone” (area CA2), and presumed interneurons of all regions. Unlike rodent and baboon CA1 pyramidal cells, human CA1 pyramidal cells appear to be devoid of CaBP‐LI. Thus, the relatively resistant dentate granule cells and CA2 pyramidal cells are the only human hippocampal principal cells that contain CaBP‐LI normally. As in lower mammals, PV‐LI is present exclusively in interneurons of all human hippocampal subregions. CaBP‐ and PV‐LI were localized in hippocampi surgically removed in the treatment of intractable temporal lobe epilepsy to determine whether surviving hippocampal cells were those that express these calcium‐binding proteins. Hippocampi removed from patients with tumors or arteriovenous malformations that were associated with complex partial seizures arising from this region appeared relatively normal histologically. CaBP‐ and PV‐LI in this patient group appeared similar to that seen in autopsy controls. Conversely, “cryptogenic” epileptics, who exhibit hippocampal sclerosis as the only lesion associated with the epilepsy, exhibited a preferential survival of hippocampal cells that were CaBP‐ or PV‐immunoreactive. In the dentate hilus, which normally contains few CaBP‐LI neurons, most of the few surviving hilar neurons were CaBP‐immunoreactive. Their number and darkness of staining suggests that CaBP synthesis may be increased in cells that survive. Despite an obvious decrease of PV‐LI specifically in the damaged parts of the sclerotic hippocampi, PV‐immunoreactive interneurons were often among the few surviving cells. Nevertheless, large expanses of the surviving granule cell layer appeared to have lost the PV‐immunoreactive axosomatic fiber plexus. These results reveal a unique and striking correlation between the human hippocampal cells that normally express these calcium‐binding proteins and those that survive in the sclerotic epileptic hippocampus.

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Sloviter R. S., 1989, Calcium‐binding protein (calbindin) and parvalbumin‐like immunoreactivity (LI) in the “normal” and “epileptic” hippocampus, Epilepsia, 30, 719

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Authors: Sloviter, R. S., Sollas, A. L., Barbaro, N. M., & Laxer, K. D.
Affiliations: New York State Department of Health (US)
University of California, San Francisco (US)
ORCID: Sloviter, Robert S.
Laxer, Kenneth D.
Venue: Journal of Comparative Neurology
Publisher: Wiley
Published: 1991-06-15
Volume: 308
Issue: 3
Pages: 381-396
ISSN: 0021-9967 (ISSN-L)
1096-9861
DOI: 10.1002/cne.903080306
OpenAlex: W2072648531
Semantic Scholar: f5fd95ae0f455c333152f81068245b21495c2179
Cited by: 349
References: 18
Citations by year: 2026: 6 · 2025: 6 · 2024: 3 · 2023: 6 · 2022: 7 · 2021: 5 · 2020: 32 · 2019: 6 · 2018: 8 · 2017: 6 · 2016: 4 · 2015: 4 · 2014: 5 · 2013: 7 · 2012: 10
FWCI: 16.16
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 4865 d)
Locations: The Journal of Comparative Neurology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of Neurological Disorders and Stroke (NS18201, R01NS018201)
Topics: Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › S100 Proteins and Annexins
Keywords: calbindin-D28k, parvalbumin, calcium-binding proteins, human hippocampus, temporal lobe epilepsy, hippocampal sclerosis, dentate gyrus granule cells, interneurons, neuronal survival, immunoreactivity, complex partial seizures, arteriovenous malformation, dentate hilus
MeSH terms: Adult, Epilepsy, Female, Hippocampus, Humans, Male, Middle Aged, Parvalbumins, Calbindins, S100 Calcium Binding Protein G, Calbindin 1

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Calcium-binding protein (calbindin-D28K) and parvalbumin immunocytochemistry in the normal and epileptic human hippocampus.

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