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Cited by 225Epilepsy research and treatmentNeuroscience and Neuropharmacology ResearchPharmacological Effects and Toxicity Studies

The kainic acid models of temporal lobe epilepsy

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Rusina, Evgeniia, Bernard, Christophe, Williamson, Adam·2021·eneuro
DOI 10.1523/eneuro.0337-20.2021PMC PMC8174050
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Abstract

Experimental models of epilepsy are useful to identify potential mechanisms of epileptogenesis, seizure genesis, comorbidities, and treatment efficacy. The kainic acid (KA) model is one of the most commonly used. Several modes of administration of KA exist, each producing different effects in a strain-, species-, gender-, and age-dependent manner. In this review, we discuss the advantages and limitations of the various forms of KA administration (systemic, intrahippocampal, and intranasal), as well as the histologic, electrophysiological, and behavioral outcomes in different strains and species. We attempt a personal perspective and discuss areas where work is needed. The diversity of KA models and their outcomes offers researchers a rich palette of phenotypes, which may be relevant to specific traits found in patients with temporal lobe epilepsy.

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Crossref · 10.1523/eneuro.0337-20.2021

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  • The kainic acid model of status epilepticus preferentially arises from the hippocampus.

    “Using a kainic acid (KA) model of status epilepticus (SE), which preferentially arises from the hippocampus (Rusina et al., 2021)”

    From APOE4 reduces hippocampal expression of phosphoglycerate kinase 1 and sodium potassium pump to enhance seizure susceptibility in mice (2026) · cites this paper as Rusina et al., 2021

    The Administration Routes > Intrahippocampal and intra-amygdaloid injections section (page unavailable) says kainic acid induces status epilepticus after injection into either the hippocampus or the amygdala. It supports the use of a kainic-acid status-epilepticus model, but does not establish that status epilepticus preferentially originates in the hippocampus. (LLM, conf=0.82)

    Experimental — accuracy not yet measured

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200 of 245 shown

Cited by

Sorted by citations

Authors
Rusina, E., Bernard, C., & Williamson, A.
Affiliations
  • Inserm (FR)
  • Linköping University (SE)
Corresponding author
Williamson, Adam
ORCID
Venue
eneuro
Publisher
Society for Neuroscience
Published
2021-03
Volume
8
Issue
2
Pages
ENEURO.0337-20.2021
ISSN
2373-2822 (ISSN-L)
DOI
10.1523/eneuro.0337-20.2021
PMC
PMC8174050
OpenAlex
W3133633028
Cited by
225
References
7
Citations by year
2026: 37 · 2025: 55 · 2024: 54 · 2023: 38 · 2022: 32 · 2021: 9
FWCI
5.94
Type
journal article
Language
en
Open access
Licence
Locations
  • eNeuro (publishedVersion, cc-by-nc-sa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • KTH Publication Database DiVA (KTH Royal Institute of Technology) (submittedVersion, other-oa)
  • HAL (submittedVersion, cc-by)
Funders
  • Excellence Initiative of Aix-Marseille University - A*MIDEX
  • EC | European Research Council (716867)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
Keywords
kainic acid, temporal lobe epilepsy, animal models of epilepsy, epileptogenesis, intranasal administration, systemic administration, strain differences, species differences, seizure genesis, behavioral phenotypes, electrophysiological outcomes, histological outcomes
MeSH terms
Animals, Disease Models, Animal, Electroencephalography, Epilepsy, Temporal Lobe, Hippocampus, Humans, Kainic Acid

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