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Cited by 76Heart Rate Variability and Autonomic ControlNeuroscience of respiration and sleepRegulation of Appetite and Obesity

Functional and anatomical organization of cardiovascular pressor and depressor sites in the lateral hypothalamic area. II. Ascending projections

Allen, Gary V., Cechetto, David F.·1993·Journal of Comparative Neurology
DOI 10.1002/cne.903300310
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Abstract

Microinjections of L‐glutamate or D, L‐homocysteic acid were used to stimulate cell bodies in the region of the lateral hypothalamic area (LHA) selectively. Subsequent iontophoretic injections of Phaseolus vulgaris ‐leucoagglutinin or pressure injections of wheat germ agglutininhorseradish peroxidase were made into regions containing identified pressor and depressor sites and their connections with the forebrain and cerebral cortex were traced. The results indicate that decreases in blood pressure (10–45 mm Hg) and heart rate (20–70 bpm) could be elicited from tuberal (LHAt) and posterior (LHAp) sites in the LHA and that these regions have ascending projections to the insular cortex, the ventral forebrain including the septal‐diagonal band of Broca complex, the ventral palladium, substantia innominata, amygdala, and the lateral preoptic area. In contrast, increases in blood pressure (10–40 mm Hg) and heart rate (20–70 bpm) were elicited primarily from neurons located adjacent to the fornix in the perifornical area (PFA). Injections of tract tracers into this region produced terminal labeling that differed markedly from the pattern seen following injections of tracer into depressor sites in the LHA. In addition, the pattern of anterograde labeling seen following injections of tracer into the anterior PFA differed from that seen following injections of tracer into posterior PFA. Injections of tracer into the anterior PFA resulted in dense terminal labeling in the medial preoptic area and the parvicellular paraventricular nucleus of the hypothalamus whereas injections into the posterior PFA resulted in dense terminal labeling in the lateral septal nucleus, nucleus accumbens, bed nucleus of the stria terminalis, as well as the medial preoptic area and the parvocellular paraventricular nucleus of the hypothalamus. The results demonstrate that the posterolateral hypothalamus of the rat contains two regions with specific cardiovascular function and highly organized connections with diencephalic, forebrain, and cortical structures.

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  • Insular cortex is interconnected with the SDMN; this connectivity includes inputs from the hypothalamus and ventral tegmental area, reciprocal connections with the amygdala and outputs to periaqueductal gray, bed nucleus of the stria terminalis, nucleus accumbens, and medial prefrontal cortex.

    “Importantly, insular cortex is interconnected with the SDMN; this connectivity includes inputs from the hypothalamus11 and ventral tegmental area12, reciprocal connections with the amygdala13 and outputs to periaqueductal gray14, bed nucleus of the stria terminalis, nucleus accumbens15, and medial prefrontal cortex16.”

    From Insular cortex mediates approach and avoidance responses to social affective stimuli (2018) · cites this paper as [11]

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Authors
Allen, G. V., & Cechetto, D. F.
Affiliations
Western University (CA)
Corresponding author
Cechetto, David F.
Venue
Journal of Comparative Neurology
Publisher
Wiley
Published
1993-04-15
Volume
330
Issue
3
Pages
421-438
ISSN
  • 0021-9967 (ISSN-L)
  • 1096-9861
DOI
10.1002/cne.903300310
OpenAlex
W4245613551
Cited by
76
References
50
Citations by year
2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 2 · 2018: 4 · 2017: 2 · 2015: 1 · 2014: 2 · 2012: 4
FWCI
3.18
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 4195 d)
Locations
The Journal of Comparative Neurology (publishedVersion)
Funders
Heart and Stroke Foundation of Canada
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords
lateral hypothalamus, perifornical area, posterior hypothalamus, ascending projections, blood pressure regulation, heart rate regulation, insula, substantia innominata, amygdala, lateral preoptic area, paraventricular nucleus, lateral septal nucleus, nucleus accumbens, bed nucleus of the stria terminalis, anterograde tracing, neural tracing, glutamate stimulation, homocysteic acid

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