Brain systems for baroreflex suppression during stress in humans

Gianaros, Peter J.; Onyewuenyi, Ikechukwu C.; Sheu, Lei K.; Christie, Israel C.; Critchley, Hugo D.

doi:10.1002/hbm.21315

Cited by 166Heart Rate Variability and Autonomic ControlCardiovascular Syncope and Autonomic DisordersNeuroscience of respiration and sleep

Brain systems for baroreflex suppression during stress in humans

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Gianaros, Peter J., Onyewuenyi, Ikechukwu C., Sheu, Lei K., Christie, Israel C., Critchley, Hugo D.·2012·Human Brain Mapping

DOI 10.1002/hbm.21315PMC PMC4116630

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Abstract

The arterial baroreflex is a key mechanism for the homeostatic control of blood pressure (BP). In animals and humans, psychological stressors suppress the capacity of the arterial baroreflex to control short‐term fluctuations in BP, reflected by reduced baroreflex sensitivity (BRS). While animal studies have characterized the brain systems that link stressor processing to BRS suppression, comparable human studies are lacking. Here, we measured beat‐to‐beat BP and heart rate (HR) in 97 adults who performed a multisource interference task that evoked changes in spontaneous BRS, which were quantified by a validated sequence method. The same 97 participants also performed the task during functional magnetic resonance imaging (fMRI) of brain activity. Across participants, task performance (i) increased BP and HR and (ii) reduced BRS. Analyses of fMRI data further demonstrated that a greater task‐evoked reduction in BRS covaried with greater activity in brain systems important for central autonomic and cardiovascular control, particularly the cingulate cortex, insula, amygdala, and midbrain periaqueductal gray (PAG). Moreover, task performance increased the functional connectivity of a discrete area of the anterior insula with both the cingulate cortex and amygdala. In parallel, this same insula area showed increased task‐evoked functional connectivity with midbrain PAG and pons. These novel findings provide human evidence for the brain systems presumptively involved in suppressing baroreflex functionality, with relevance for understanding the neurobiological mechanisms of stressor‐related cardiovascular reactivity and associated risk for essential hypertension and atherosclerotic heart disease. Hum Brain Mapp, 2011. © 2011 Wiley‐Liss, Inc.

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In social interaction, insula is involved in emotional processing and empathy but it is fundamentally implicated in homeostasis; mapping and controlling autonomic functions and regulation of the sympathetic and parasympathetic systems.
“In social interaction, insula is involved in emotional processing and empathy (Lamm and Singer, 2010) but it is fundamentally implicated in homeostasis; mapping and controlling autonomic functions and regulation of the sympathetic and parasympathetic systems (Gianaros et al., 2012; Critchley and Harrison, 2013).”
From Neuroimaging and psychophysiological investigation of the link between anxiety, enhanced affective reactivity and interoception in people with joint hypermobility (2014) · cites this paper as Gianaros et al., 2012

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Gray MA Minati L Harrison NA Gianaros PJ Napadow V Critchley HD 2009a Physiological recordings: Basic concepts and implementation in the fMRI scanner NeuroImage 47 1105 1115 19460445 PMC2741582
McEwen BS Gianaros PJ Plasticity of the brain in relationship to stress Annu Rev Med 62 431 445 20707675 PMC4251716
Wager TD Waugh CE Lindquist MA Noll DC Fredrickson BL Taylor SF 2009b Brain mediators of cardiovascular responses to social threat. I. Reciprocal dorsal and ventral sub-regions of the medial prefrontal cortex and heart-rate reactivity NeuroImage 47 821 835 19465137 PMC3275821

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Authors: Gianaros, P. J., Onyewuenyi, I. C., Sheu, L. K., Christie, I. C., & Critchley, H. D.
Affiliations: University of Pittsburgh (US)
Brighton and Sussex Medical School (GB)
ORCID: Gianaros, Peter J.
Christie, Israel C.
Critchley, Hugo D.
Venue: Human Brain Mapping
Publisher: Wiley
Published: 2011-05-12
Volume: 33
Issue: 7
Pages: 1700-1716
ISSN: 1065-9471 (ISSN-L)
1097-0193
DOI: 10.1002/hbm.21315
PMC: PMC4116630
OpenAlex: W2012387279
Cited by: 166
References: 118
Citations by year: 2026: 8 · 2025: 9 · 2024: 13 · 2023: 9 · 2022: 9 · 2021: 13 · 2020: 6 · 2019: 11 · 2018: 11 · 2017: 7 · 2016: 10 · 2015: 18 · 2014: 14 · 2013: 20 · 2012: 7
FWCI: 9.24
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Human Brain Mapping (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Figshare (submittedVersion, cc-by)
Funders: National Heart, Lung, and Blood Institute (R01HL089850)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
Keywords: baroreflex sensitivity, psychological stress, blood pressure regulation, heart rate, anterior insula, cingulate cortex, amygdala, periaqueductal gray, functional connectivity, central autonomic control, cardiovascular reactivity, essential hypertension, atherosclerotic heart disease
MeSH terms: Adult, Blood Pressure, Brain, Female, Heart Rate, Humans, Male, Middle Aged, Neural Inhibition, Psychomotor Performance, Stress, Psychological, Baroreflex

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