The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Projections of the suprachiasmatic nucleus to stress-related areas in the rat hypothalamus: A light and electron microscopic study
Open accessAbstract
The purpose of the present study was to investigate the sites in the hypothalamus where the suprachiasmatic nucleus (SCN) may influence corticosteroid secretion. In spite of the well established, SCN-mediated, daily rhythms in adrenocorticotrophic hormone (ACTH) and corticosteroid secretion, previous studies determining the projections of the suprachiasmatic nucleus failed to illustrate direct connections with corticotrophin-releasing hormone neurons (CRH). In order to identify where in the central nervous system the SCN may influence corticosteroid secretion, areas were selected that contained SCN efferents contacting neurons involved in the stress response. To achieve this in the present study, SCN efferents were visualized by Pha-L tract-tracing, together with the neurons involved in the stress response by immunocytochemical staining for c-fos protein. The sites where these efferents contacted c-fos-positive neurons were established by light microscopic double staining and electron microscopic immunocytochemical studies. It appeared that apart from the medial parvocellular area of the paraventricular nucleus (PVN) of the hypothalamus, many more regions showed fos-positive neurons. Sites where SCN efferents contacted such neurons are limited only to areas immediately adjacent to these putative CRH neurons but are not concentrated on these neurons themselves. These areas consist of the periventricular and rostral PVN together with the dorsomedial hypothalamus: all three regions are known to project into the PVN. Therefore, it is concluded that the SCN transmits its information related to corticosteroid secretion via interneurons in and around the PVN to the CRH-containing neurons, rather than by a direct interaction with these neurons themselves.
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“That the SCN may modulate cardiovascular functioning is suggested by the presence of multisynaptic projections from the SCN to the heart and organs that regulate cardiovascular function through hormones and blood volume regulation (e.g., adrenal cortex, adrenal medulla, and kidneys”
From The impact of the circadian timing system on cardiovascular and metabolic function (2012) · cites this paper as Buijs et al., 1993
In the citing paper
“The vasopressinergic neurons from the SCN have an inhibitory effect on CRH neurons in the PVN (Buijs et al., 1993; Hermes et al., 1996).”
From The impact of the circadian timing system on cardiovascular and metabolic function (2012) · cites this paper as Buijs et al., 1993
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Self-citation
Metadata
- Authors
- Buijs, R. M., Markman, M., Nunes‐Cardoso, B., Hou, Y., & Shinn, S.
- Corresponding author
- Buijs, Ruud M.
- ORCID
- Buijs, Ruud M.
- Venue
- Journal of Comparative Neurology
- Publisher
- Wiley
- Published
- 1993-09
- Volume
- 335
- Issue
- 1
- Pages
- 42-54
- ISSN
- 0021-9967 (ISSN-L)
- 1096-9861
- OpenAlex
- W2026488175
- Cited by
- 153
- References
- 27
- Citations by year
- 2026: 2 · 2023: 1 · 2022: 4 · 2021: 3 · 2020: 1 · 2019: 3 · 2018: 1 · 2017: 1 · 2015: 4 · 2014: 5 · 2013: 5 · 2012: 5
- FWCI
- 3.69
- Type
- journal article
- Language
- en
- Open access
- green
- pure.knaw.nl
- Licence
- Locations
- The Journal of Comparative Neurology (publishedVersion)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (submittedVersion)
- Funders
- Medical Research Council
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- suprachiasmatic nucleus, hypothalamus, corticosteroid secretion, c-fos, paraventricular nucleus, dorsomedial hypothalamus, stress response, daily rhythms, ACTH, interneurons
- MeSH terms
- Adrenal Cortex Hormones, Adrenocorticotropic Hormone, Animals, Efferent Pathways, Immunohistochemistry, Male, Microscopy, Microscopy, Electron, Neurons, Phytohemagglutinins, Staining and Labeling, Stress, Physiological, Suprachiasmatic Nucleus, Vasoactive Intestinal Peptide, Vasopressins, Proto-Oncogene Proteins c-fos, Rats, Wistar, Rats
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