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Cited by 153Stress Responses and CortisolCircadian rhythm and melatoninHypothalamic control of reproductive hormones

The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.

Projections of the suprachiasmatic nucleus to stress-related areas in the rat hypothalamus: A light and electron microscopic study

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Buijs, Ruud M., Markman, Marry, Nunes‐Cardoso, Bob, Hou, Yang‐Xun, Shinn, Susan·1993·Journal of Comparative Neurology
DOI 10.1002/cne.903350104
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Abstract

The purpose of the present study was to investigate the sites in the hypothalamus where the suprachiasmatic nucleus (SCN) may influence corticosteroid secretion. In spite of the well established, SCN-mediated, daily rhythms in adrenocorticotrophic hormone (ACTH) and corticosteroid secretion, previous studies determining the projections of the suprachiasmatic nucleus failed to illustrate direct connections with corticotrophin-releasing hormone neurons (CRH). In order to identify where in the central nervous system the SCN may influence corticosteroid secretion, areas were selected that contained SCN efferents contacting neurons involved in the stress response. To achieve this in the present study, SCN efferents were visualized by Pha-L tract-tracing, together with the neurons involved in the stress response by immunocytochemical staining for c-fos protein. The sites where these efferents contacted c-fos-positive neurons were established by light microscopic double staining and electron microscopic immunocytochemical studies. It appeared that apart from the medial parvocellular area of the paraventricular nucleus (PVN) of the hypothalamus, many more regions showed fos-positive neurons. Sites where SCN efferents contacted such neurons are limited only to areas immediately adjacent to these putative CRH neurons but are not concentrated on these neurons themselves. These areas consist of the periventricular and rostral PVN together with the dorsomedial hypothalamus: all three regions are known to project into the PVN. Therefore, it is concluded that the SCN transmits its information related to corticosteroid secretion via interneurons in and around the PVN to the CRH-containing neurons, rather than by a direct interaction with these neurons themselves.

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Research works printed but not linked: 3

  1. Ceccatelli S., 1989, Expression ofc‐fos immunoreactivity in transmitter‐characterized neurons after stress, Neurobiology, 86, 9569
  2. Dallman M. F., 1978, Nycthemeral rhythrn in adrenal responsiveness to ACTH, Am. J. Physiol., 235, R210
  3. Swanson L. W., 1987, Integrated Systems ofthe CNS, Part l: hypothalamus, 1

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Metadata

Authors
Buijs, R. M., Markman, M., Nunes‐Cardoso, B., Hou, Y., & Shinn, S.
Corresponding author
Buijs, Ruud M.
ORCID
Buijs, Ruud M.
Venue
Journal of Comparative Neurology
Publisher
Wiley
Published
1993-09
Volume
335
Issue
1
Pages
42-54
ISSN
  • 0021-9967 (ISSN-L)
  • 1096-9861
DOI
10.1002/cne.903350104
OpenAlex
W2026488175
Cited by
153
References
27
Citations by year
2026: 2 · 2023: 1 · 2022: 4 · 2021: 3 · 2020: 1 · 2019: 3 · 2018: 1 · 2017: 1 · 2015: 4 · 2014: 5 · 2013: 5 · 2012: 5
FWCI
3.69
Type
journal article
Language
en
Open access
Licence
Locations
  • The Journal of Comparative Neurology (publishedVersion)
  • PubMed (publishedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
  • KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (submittedVersion)
Funders
Medical Research Council
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords
suprachiasmatic nucleus, hypothalamus, corticosteroid secretion, c-fos, paraventricular nucleus, dorsomedial hypothalamus, stress response, daily rhythms, ACTH, interneurons
MeSH terms
Adrenal Cortex Hormones, Adrenocorticotropic Hormone, Animals, Efferent Pathways, Immunohistochemistry, Male, Microscopy, Microscopy, Electron, Neurons, Phytohemagglutinins, Staining and Labeling, Stress, Physiological, Suprachiasmatic Nucleus, Vasoactive Intestinal Peptide, Vasopressins, Proto-Oncogene Proteins c-fos, Rats, Wistar, Rats

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