A diffusion tensor imaging study of white matter in obsessive–compulsive disorder
Abstract
Our objective was to test for differences between subjects with obsessive-compulsive disorder (OCD) and healthy controls with respect to white matter architecture within the cingulum bundle (CB) and anterior limb of the internal capsule (ALIC). We studied eight subjects with active OCD and 10 matched healthy controls using diffusion tensor magnetic resonance imaging (DT-MRI) at 1.5 T (Tesla). Fractional anisotropy (FA) was evaluated in both CB and ALIC. Both voxelwise and region-of-interest methods of analysis were employed. Within both the left CB and the left ALIC, subjects with OCD exhibited significantly greater FA than healthy controls. In the right CB, subjects with OCD exhibited significantly decreased FA versus healthy control subjects. Additionally, the OCD group exhibited abnormal asymmetry (left > right) of FA in the CB. These results provide preliminary evidence for abnormal architecture within the CB and ALIC in OCD. FA differences in these areas are consistent with the presence of abnormal connections between the nodes linked by these tracts. This could explain why surgically severing these tracts is therapeutic. Additional studies are needed to replicate these findings and to clarify their pathological and clinical significance.
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Different parts of the cingulum may show opposite changes in diffusivity in both PTSD and OCD.
“the finding that different parts of the cingulum may show opposite changes in diffusivity in both PTSD (Daniels et al., 2013) and OCD (Cannistraro et al., 2007)”
From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Cannistraro et al., 2007
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- Authors
- Cannistraro, P. A., Makris, N., Howard, J. D., Wedig, M. M., Hodge, S. M., Wilhelm, S., Kennedy, D. N., & Rauch, S. L.
- Affiliations
- Massachusetts General Hospital (US)
- Corresponding author
- Rauch, Scott L.
- Venue
- Depression and Anxiety
- Publisher
- Hindawi Limited
- Published
- 2007
- Volume
- 24
- Issue
- 6
- Pages
- 440-446
- ISSN
- 1091-4269 (ISSN-L)
- 1520-6394
- OpenAlex
- W2055251602
- Cited by
- 154
- References
- 6
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 1 · 2023: 4 · 2022: 3 · 2021: 6 · 2020: 6 · 2019: 3 · 2018: 6 · 2017: 3 · 2016: 12 · 2015: 11 · 2014: 15 · 2013: 13 · 2012: 17
- FWCI
- 9.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Depression and Anxiety (publishedVersion, public-domain)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5t32eb001632-05, 5r01mh060219-05)
- National Institute of Mental Health (MH 60219)
- National Institute of Biomedical Imaging and Bioengineering (EB001632-01)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Keywords
- obsessive-compulsive disorder, white matter, cingulum, anterior limb of the internal capsule, fractional anisotropy, white matter architecture, hemispheric lateralization, diffusion tensor imaging
- MeSH terms
- Adolescent, Adult, Dominance, Cerebral, Female, Gyrus Cinguli, Humans, Image Processing, Computer-Assisted, Male, Nerve Fibers, Myelinated, Nerve Net, Obsessive-Compulsive Disorder, Reference Values, Internal Capsule, Diffusion Magnetic Resonance Imaging
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