Duration effect of obsessive–compulsive disorder on cognitive function: a functional MRI study
Abstract
BACKGROUND: The inconsistency of previous reports examining cognitive function in obsessive-compulsive disorder (OCD) suggests its heterogeneity. In this study, we examined the effect of illness duration on cognitive function in OCD. METHODS: We examined the cognitive function of 32 OCD patients and 16 healthy volunteers by neuropsychological tests and functional magnetic resonance imaging while they performed the Stroop and N-back tasks to assess attention and nonverbal memory. The patients were divided into two groups by illness duration: a short-term group (n=17, 5.5+/-3.1 years) and a long-term group (n=15, 20.3+/-6.1 years). Statistical analysis was performed to determine the differences between these two groups and the normal control group (n=16). RESULTS: The long-term group showed attention deficit and nonverbal memory dysfunction on the neuropsychological tests. In contrast, on functional magnetic resonance imaging, the short-term group showed weaker activation of the right caudate during the Stroop task and stronger activation of the right dorso-lateral prefrontal cortex during the N-back task than the long-term and normal control groups. CONCLUSIONS: The results suggested that abnormal brain activation occurs in the early phase of OCD and that the long-term persistence of OCD might involve a decline in cognitive function.
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We did not assess potential effects of medication status or duration of illness in the included OCD samples.
“Additionally, we did not assess potential effects of medication status (Boedhoe et al., 2018) or duration of illness (Nakao et al., 2009) in the included OCD samples.”
From Inhibitory control in obsessive compulsive disorder: a systematic review and activation likelihood estimation meta-analysis of functional magnetic resonance imaging studies (2022) · cites this paper as Nakao et al., 2009
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- Authors
- Nakao, T., Nakagawa, A., Yoshiura, T., Nakatani, E., Nabeyama, M., Sanematsu, H., Togao, O., Yoshioka, K., Tomita, M., Kuroki, T., & Kanba, S.
- Affiliations
- Kyushu University (JP)
- Corresponding author
- Nakao, Tomohiro
- Venue
- Depression and Anxiety
- Publisher
- Hindawi Limited
- Published
- 2009-09
- Volume
- 26
- Issue
- 9
- Pages
- 814-823
- ISSN
- 1091-4269 (ISSN-L)
- 1520-6394
- OpenAlex
- W1982417738
- Cited by
- 34
- References
- 46
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 4 · 2021: 3 · 2020: 1 · 2019: 2 · 2017: 2 · 2016: 2 · 2015: 4 · 2014: 4 · 2013: 2 · 2012: 2
- FWCI
- 1.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Depression and Anxiety (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- obsessive-compulsive disorder, disease duration, cognitive function, attention, nonverbal memory, Stroop task, n-back task, caudate nucleus, dorsolateral prefrontal cortex, brain activation
- MeSH terms
- Adolescent, Adult, Brain, Caudate Nucleus, Cognition Disorders, Dominance, Cerebral, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Memory, Short-Term, Middle Aged, Neuropsychological Tests, Obsessive-Compulsive Disorder, Psychometrics, Retention, Psychology, Prefrontal Cortex, Young Adult, Stroop Test
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