THE R-DOC INITIATIVE: SCIENCE AND PRACTICE: Special Article: The R-DOC Initiative
Open accessAbstract
A research focus upon dimensions of observable behaviors and neurobiological indices, as outlined in the R-DoC initiative, is likely to enhance our understanding of psychopathology in a number of ways that are outlined in this article. Specific examples include a greater understanding of the mechanisms underlying comorbidity and complexity of symptom manifestation, individual differences in symptom expression, and developmental changes in symptom expression. Furthermore, the R-DoC approach may have treatment implications, including treatment efficacy, and identification of treatment moderators and treatment mediators.
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Focusing on inflammation's role in more homogeneous core features of depression is likely to improve understanding and treatment of major depressive disorder.
“Thus, it is likely that a better understanding of Major Depressive Disorder and its effective treatment will emerge by focusing on the role of inflammation in the onset and maintenance of more homogenous core features that are disrupted among depressed patients (Craske, 2012; Gottesman and Gould, 2003; Hasler et al., 2004).”
From The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation. (2018) · cites this paper as Craske, 2012
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- Authors
- Craske, M. G.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- Craske, Michelle G.
- ORCID
- Craske, Michelle G.
- Venue
- Depression and Anxiety
- Publisher
- Hindawi Limited
- Published
- 2012-04
- Volume
- 29
- Issue
- 4
- Pages
- 253-256
- ISSN
- 1091-4269 (ISSN-L)
- OpenAlex
- W1784306623
- Cited by
- 41
- References
- 20
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 3 · 2021: 1 · 2020: 5 · 2019: 2 · 2018: 5 · 2017: 3 · 2016: 5 · 2015: 4 · 2014: 5 · 2013: 3
- FWCI
- 5.14
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Depression and Anxiety (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Keywords
- Research Domain Criteria, psychopathology, observable behavior, comorbidities, symptom complexity, treatment moderators, treatment efficacy
- MeSH terms
- Mental Disorders, Humans, Psychopathology, Practice Guidelines as Topic
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