Sex differences in orbitofrontal connectivity in male and female veterans with TBI
Open accessAbstract
More female soldiers are now serving in combat theaters than at any other time. However, little is known about possible sex differences underlying the neuropathology and manifestation of one of modern war's signature injuries, traumatic brain injury (TBI). The paucity of information regarding sex differences in TBI is particularly evident when examining changes in executive function and emotion regulation associated with post concussive events. The current study objective was to observe whether patterns of orbitofrontal (OFC) functional connectivity would differ between female veterans with TBI and their male counterparts. The study further sought to determine whether OFC connectivity might be differentially associated with clinical measures of aggression and hostility. Seventeen female veterans and 24 male veterans, age 18 to 25, who met criteria for TBI completed resting state magnetic resonance imaging (MRI) and clinical assessment measures. Imaging data were analyzed using left and right seed regions of the OFC, and regression analyses were conducted to observe the relationship between resting state connectivity and self-reported aggression. Females and males in this study differed in OFC connectivity, with females demonstrating greater connectivity between left and right OFC and parietal and occipital regions and males demonstrating greater connectivity between left and right OFC and frontal and temporal regions. Significant associations between resting state connectivity and clinical measures were found only in male veterans. These findings suggest that TBI may interact with sex-specific patterns of brain connectivity in male and female veterans and exert divergent effects on clinical profiles of aggression post-injury.
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Higher connectivity between various brain regions is associated with less physical aggression in women veterans than men post-TBI.
“Moreover, higher connectivity between various brain regions was associated with less physical aggression in women veterans than men post-TBI. 27”
From Sex Differences in Traumatic Brain Injury: What We Know and What We Should Know (2019) · cites this paper as [27]
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- Authors
- McGlade, E., Rogowska, J., & Yurgelun-Todd, D.
- Affiliations
- University of Utah (US)
- Corresponding author
- McGlade, Erin
- Venue
- Brain Imaging and Behavior
- Published
- 2015-04-12
- Volume
- 9
- Issue
- 3
- Pages
- 535-549
- ISSN
- 1931-7557 (ISSN-L)
- 1931-7565
- PMC
- PMC4575683
- OpenAlex
- W1967084138
- Cited by
- 63
- References
- 97
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 6 · 2023: 4 · 2022: 3 · 2021: 10 · 2020: 14 · 2019: 8 · 2018: 4 · 2017: 1 · 2016: 3 · 2015: 1 · 2014: 2
- FWCI
- 2.35
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Brain Imaging and Behavior (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Veterans Affairs (I01 CX000253)
- Topics
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Keywords
- traumatic brain injury, sex differences, orbitofrontal cortex, resting-state functional connectivity, women veterans, aggression, hostility, post-concussion symptoms, executive function, emotion regulation, war injuries
- MeSH terms
- Adolescent, Adult, Aggression, Brain Injuries, Brain Mapping, Depressive Disorder, Major, Major Depressive Disorder, Female, Hostility, Humans, Magnetic Resonance Imaging, Male, Neural Pathways, Psychiatric Status Rating Scales, Rest, Severity of Illness Index, Sex Characteristics, Stress Disorders, Post-Traumatic, Veterans, Comorbidity, Prefrontal Cortex, Young Adult
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