Cited by 205Transcranial Magnetic Stimulation StudiesTreatment of Major DepressionElectroconvulsive Therapy Studies

A STUDY OF THE PATTERN OF RESPONSE TO rTMS TREATMENT IN DEPRESSION: Research Article: rTMS in Depression

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Fitzgerald, Paul B., Hoy, Kate E., Anderson, Rodney J., Daskalakis, Zafiris J.·2016·Depression and Anxiety

Abstract

BACKGROUND: Considerable research has demonstrated the efficacy of repetitive transcranial magnetic stimulation (rTMS) treatment in patients with depression. However, limited research has described the pattern of response to rTMS treatment or explored possible predictors of the likelihood of treatment response. METHODS: Data from 11 clinical trials (n = 1,132) was pooled and we described the pattern of response to rTMS, rate of response, and remission as well as potential clinical and demographic predictors of response. RESULTS: There was a bimodal pattern of response to rTMS with the response-associated peak at 57% reduction in depression rating scale scores. About 46% of patients achieved response criteria, with 31% completing rTMS treatment in remission. A greater likelihood of response was seen for patients who had less severe depression at baseline, a shorter duration of the current episode, and recurrent rather than single episode of depression. Greater response was also seen in patients treated at higher stimulation intensity. CONCLUSIONS: A meaningful percentage (>40%) of patients respond to a course of rTMS treatment. Response does vary with a number of clinical and demographic variables but none of these variables exert a sufficiently strong influence on response rates to warrant using these criteria to exclude patients from treatment.

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  1. Fitzgerald PB, Brown TL, Marston NAU, et al. Transcranial mag- netic stimulation in the treatment of depression: a double-blind, placebo-controlled trial. Arch. Gen. Psychiatry 2003;60:1002- 1008.

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Authors
Fitzgerald, P. B., Hoy, K. E., Anderson, R. J., & Daskalakis, Z. J.
Affiliations
  • The Alfred Hospital (AU)
  • Centre for Addiction and Mental Health (CA)
Corresponding author
Fitzgerald, Paul B.
Venue
Depression and Anxiety
Publisher
Wiley
Published
2016-04-05
Volume
33
Issue
8
Pages
746-753
ISSN
1091-4269 (ISSN-L)
OpenAlex
W2342215476
Cited by
204
References
27
Citations by year
2026: 26 · 2025: 28 · 2024: 28 · 2023: 21 · 2022: 18 · 2021: 24 · 2020: 16 · 2019: 23 · 2018: 8 · 2017: 8 · 2016: 4
FWCI
7.85
Type
journal article
Language
en
Open access
Locations
  • Depression and Anxiety (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Health and Medical Research Council (1041890, 1078567, 1082894)
  • Alfred Research Trusts, Alfred Health
Topics
  • Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
Keywords
repetitive transcranial magnetic stimulation, depression, treatment response, predictors of treatment response, remission, depression severity, recurrent depression, stimulation intensity
MeSH terms
Adolescent, Adult, Aged, Aged, 80 and over, Major Depressive Disorder, Female, Humans, Male, Middle Aged, Outcome Assessment, Health Care, Transcranial Magnetic Stimulation, Young Adult

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