Efficacy of an acceptance-based group behavioral therapy for generalized anxiety disorder.
Open accessAbstract
Background: Generalized anxiety disorder (GAD) shows the weakest treatment response among anxiety disorders. This study aimed at examining whether an acceptance-based group behavioral therapy (ABBT) for patients in a Brazilian anxiety disorders program, combining mindfulness and exposure strategies, can improve clinical outcome when compared with a standard nondirective supportive group therapy (NDST).Methods: Ninety-two individuals diagnosed with GAD were randomized to receive 10 sessions of either ABBT or NDST. Assessments at pretreatment, midtreatment, posttreatment, and 3-month follow-up comprised the following outcome measures: Hamilton Anxiety Rating Scale (HAM-A), Penn State Worry Questionnaire (PSWQ), Depression Anxiety and Stress Scale (DASS), and the Clinical Global Impressions (CGI). The World Health Organization Quality of Life (WHOQOL) was administered at pretreatment and posttreatment.Results: The mixed-effects regression models for DASS-stress, Hamilton Anxiety Interview, and CGI showed a significant effect for Time and the Time × Treatment effect, but not for the Treatment main effect. Similarly, there was a significant Time × Treatment effect for the PSWQ, but not main effects of Time or Treatment. Altogether, these data indicate that symptoms decreased in both conditions across treatment and follow-up, and that the rate of change was more rapid for those participants in the ABBT condition. We found no differences between groups from pretreatment to posttreatment in DASS-anxiety or any secondary outcome measure, but for the physical health domain of WHOQOL, which was faster in ABBT.Conclusions: Both groups showed good clinical outcomes, but in general, participants of the ABBT group improved faster than those in the NDST group.
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Claims the paper makes
5 of 27 cited sources checked · 4 supported · 0 flagged · accuracy not yet measured
- Premisecitation
In individuals with GAD, worries function as a strategy to avoid negative emotional contrast by keeping tonic anxiety high.
“function, in individuals with GAD, as a strategy to avoid negative emotional contrast, by keeping tonic anxiety high (Llera & Newman, 2010;Newman & Llera, 2011).”
Quote in the paperSubstantial claim1 of 2 sources checked - Premisecitation
In a comparative trial using applied relaxation as a control, there were no clinical improvement differences between treatments.
“in a comparative trial using an empirically based treatment (i.e., applied relaxation) as a control group, they found no clinical improvement differences between treatments”
Quote in the paperSubstantial claim1 of 1 sources checked- cites Hayes-Skelton, Roemer, & Orsillo, 2013 source
- Interpretationcitation
The ABBT results, including those on DASS-anxiety, are similar to what was reported in Roemer et al. (2008).
“The ABBT results, including those on DASS-anxiety, are similar to what was reported inRoemer et al. (2008).”
Quote in the paperNot a substantial claim1 of 1 sources checked- cites Roemer et al. (2008) source
- Premisecitation
Group treatments for anxiety disorders have approximately twice the attrition rate of individual treatments.
“The comparison between adherences to individual (Hunot, Churchill, Silva de Lima, & Teixeira, 2007) and group (Issakidis & Andrews, 2004) treatments for anxiety disorders suggests that the latter has approximately twice the attrition rate of the former.”
Quote in the paperNot a substantial claim1 of 2 sources checked - Findingown data
The clinical worsening from posttreatment to follow-up on WHOQOL-physical was particularly driven by NDST participants.
“however, this clinical worsening is particularly driven by those participants in the NDST condition.”
Quote in the paperNot a substantial claim
- Findingown data
No other Time × Treatment effects were significant from posttreatment to follow-up.
“but no other Time × Treatment effects were significant.”
Quote in the paperNot a substantial claim - Findingown data
The rate of change was more rapid for those participants in the ABBT condition.
“and that the rate of change was more rapid for those participants in the ABBT condition.”
Quote in the paperSubstantial claim - Findingown data
In both treatments, symptoms decreased across treatment and follow-up.
“indicating that in both treatments, symptoms decreased across treatment and follow-up”
Quote in the paperSubstantial claim - Findingown data
Those in the ABBT group experienced a more rapid decrease in PSWQ compared with those in the NDST group.
“indicating that those in the ABBT group experienced a more rapid decrease in PSWQ compared with those in the NDST group.”
Quote in the paperSubstantial claim - Findingown data
There were no significant effects for the WHOQOL-social.
“There were no significant effects for the WHOQOL-social.”
Quote in the paperNot a substantial claim - Findingown data
Patients in both treatments experienced significant decreases in DASS-anxiety symptoms regardless of treatment condition.
“indicating that patients in both treatments experienced significant decreases in their symptoms regardless of treatment condition.”
Quote in the paperSubstantial claim - Findingown data
The effect of Time was nonsignificant for the other outcome measures from posttreatment to follow-up.
“however, the effect of Time was nonsignificant for the other outcome measures.”
Quote in the paperSubstantial claim - Findingown data
For WHOQOL-physical, there was a significant Time × Treatment effect (p = .047), indicating a more rapid increase for ABBT compared with NDST.
“However, for WHOQOL-physical, there was a significant Time × Treatment effect (p = .047),indicating a more rapid increase for those in ABBT compared with NDST.”
Quote in the paperNot a substantial claim - Findingreasoning
ABBT showed better maintenance of gains compared with NDST from posttreatment to follow-up.
“Although clinical impairment in all secondary measures was seen from posttreatment to follow-up, ABBT showed better maintenance of gains compared with NDST.”
Quote in the paperSubstantial claim - Findingown data
The most significant outcome difference between groups was observed in the PSWQ.
“The most significant outcome difference between groups was observed in the PSWQ; which is consistent with our ABBT protocol directly targeting worry, whether through mindfulness skills training or exposure to mental images.”
Quote in the paperNot a substantial claim - Findingown data
Both groups showed larger effect sizes for the physical and psychological health domains of WHOQOL than for the social relationships domain.
“As expected, both groups showed larger effect sizes for the physical and psychological health domains of WHOQOL (ABBT, large for both; NDST, large and medium, respectively) then for the social relationships domain (small for both groups).”
Quote in the paperNot a substantial claim - Findingnone given
In general, participants in the ABBT group improved more rapidly.
“Nevertheless, in general, participants in the ABBT group improved more rapidly.”
Quote in the paperNot a substantial claim - Findingnone given
Both conditions showed good clinical outcomes.
“As expected, both conditions showed good clinical outcomes.”
Quote in the paperSubstantial claim - Premisecitation
Among anxiety disorders, generalized anxiety disorder (GAD) has the most chronic course.
“Among anxiety disorders, generalized anxiety disorder (GAD) has the most chronic course (Keller, 2002)”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Keller, 2002
- Premisecitation
GAD shows the lowest treatment response rate among anxiety disorders.
“shows the lowest treatment response rate (Craske & Waters, 2005)”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Craske & Waters, 2005 source
- Study design and conductown data
Overall, therapists showed good adherence to the protocols.
“Overall, we shall consider that therapists showed good adherence to the protocols.”
Quote in the paperNot a substantial claim - Study design and conductown data
For each primary outcome variable, there were nonsignificant effects for Completer Status × Time × Treatment Group (p's from .36 to .98).
“For each primary outcome variable, there were nonsignificant effects for Completer Status × Time × Treatment Group (p's from .36 to .98).”
Quote in the paperSubstantial claim - Premisecitation
Supportive therapies are considered a better form of control than treatment as usual or waiting-list conditions in clinical trials.
“By isolating approach-specific factors, supportive therapies are considered a better form of control than treatment as usual/waiting-list conditions in clinical trials (Markovitz, 2014).”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Markovitz, 2014
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Study design and conductcitation
To guarantee internal validity, participants with more than two session absences or any consecutive absences were excluded and referred to other treatment options.
“To guarantee the internal validity of the interventions, we excluded participants with more than two session absences or any consecutive absences from the project and immediately referred them to other treatment options.”
Quote in the paperSubstantial claim - Premisereasoning
It is still unknown if a group ABBT protocol based on Roemer and Orsillo's GAD model is efficacious for GAD.
“Thus, it is still unknown if such a protocol is efficacious for GAD.”
Quote in the paperSubstantial claim - Study design and conductown data
In the NDST condition, 35 (89.7%) required strategies were rated as satisfactorily present.
“Similarly, in the NDST condition, 35 (89.7%) required strategies were rated as satisfactorily present.”
Quote in the paperNot a substantial claim - Premisecitation
Group CBT can be as effective as individual CBT for anxiety-related disorders.
“some studies indicate that group CBT can be as effective as individual CBT for anxietyrelated disorders (Oie & Boschen, 2009;Pozza & Dèttore, 2017;Sharp, Power, & Swanson, 2004;van Ingen & Novicki, 2009).”
Quote in the paperSubstantial claim0 of 3 sources checked - Study design and conductown data
The dropout rate was higher than expected in both groups (ABBT n = 25 or 54%; NDST n = 23 or 50%).
“Regarding attrition, the dropout rate was higher than expected in both groups (ABBT n = 25 or 54%; NDST n = 23 or 50%).”
Quote in the paperNot a substantial claim - Interpretationown data
Maximum likelihood estimation was an appropriate method for analyzing these data.
“These results indicate that maximum likelihood estimation was an appropriate method for analyzing these data.”
Quote in the paperSubstantial claim - Premisecitation
The existing paper on group ABBT does not report efficacy data.
“and it does not report efficacy data (Heatherington et al., 2014).”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Heatherington et al., 2014 source
- Interpretationown data
In clinical terms, all primary outcome measures but DASS-anxiety showed significantly greater improvement for ABBT compared with NDST.
“In clinical terms, data show that all primary outcome measures but DASS-anxiety showed significantly greater improvement for the participants of the ABBT group when compared with those in the NDST group.”
Quote in the paperSubstantial claim - Study design and conductown data
For the ABBT group, dropouts before Week 6 (n = 12 or 26%) and after Week 6 (n = 13 or 28.2%) showed a steady dropout rate.
“For the ABBT group, when comparing the number of dropouts before Week 6 (n = 12 or 26%) with the number of dropouts after Week 6 (n = 13 or 28.2%), we observed a steady dropout rate.”
Quote in the paperNot a substantial claim - Premisecitation
There is just one paper in the literature on group ABBT using a protocol based on Roemer and Orsillo's GAD model.
“However, there is just one paper in the literature on group ABBT using a protocol based on Roemer and Orsillo's GAD model”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Heatherington et al., 2014 source
- Interpretationreasoning
These results generally indicate maintenance of gains across follow-up.
“These results generally indicate the maintenance of gains across follow-up.”
Quote in the paperSubstantial claim - Interpretationreasoning
It is unclear how effective this intervention would be in routine clinical practice.
“Thus, it is unclear how effective this intervention would be in routine clinical practice.”
Quote in the paperSubstantial claim - Study design and conductnone given
The lack of an assessment tool to assess the quality of the delivered interventions was a limitation.
“Another limitation was that, regardless of the use of an adherence checklist, the lack of an assessment tool to assess the quality of the delivered interven-”
Quote in the paperNot a substantial claim - Premisecitation
The physical and psychological health domains of the WHOQOL are most related to GAD.
“This result supports the literature showing the physical and psychological health domains of the WHOQOL to be most related to GAD (Olatunji, Cisler, & Tolin, 2007).”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Olatunji, Cisler, & Tolin, 2007 source
- Study design and conductnone given
The absence of an outcome measure that assesses GAD remission precluded us from determining how many participants remitted from GAD after treatment.
“Still, the absence of an outcome measure that assesses GAD remission precluded us from determining how many participants remitted from GAD after treatment.”
Quote in the paperSubstantial claim - Interpretationown data
Generally, these effect sizes are similar to those found in this ABBT trial at posttreatment and follow-up respectively (PSWQ d = 1.17 and 0.96; DASS-stress d = 1.21 and 1.07; DASS-anxiety d = 0.80 and 0.74).
“Generally, these effect sizes are similar to those found in this ABBT trial at posttreatment and follow-up respectively (PSWQ d = 1.17 and 0.96; DASS-stress d = 1.21 and 1.07; DASSanxiety d = 0.80 and 0.74).”
Quote in the paperSubstantial claim - Interpretationreasoning
Since no interventions were designed for depressive symptoms in any of the protocols, secondary depression may take longer to show significant improvement.
“Thus, since no interventions were designed for depressive symptoms in any of the protocols, secondary depression may take longer to show significant improvement.”
Quote in the paperSubstantial claim - Interpretationreasoning
The high dropout rate appears to be a weakness of group therapies.
“Indeed, the high dropout rate appears to be a weakness of group therapies.”
Quote in the paperNot a substantial claim - Interpretationreasoning
The lack of any patient retention strategy, such as calls or e-mails between sessions, whenever participants were absent, may have played a decisive role in the attrition rate of both groups.
“and (b) the lack of any patient retention strategy, such as calls or e-mails between sessions, whenever participants were absent.”
Quote in the paperNot a substantial claim - Premisecitation
Depressive symptoms are usually secondary to GAD.
“These results may be partially explained by the findings that depressive symptoms are usually secondary to GAD (Hettema, Prescott, & Kendler, 2003).”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Hettema, Prescott, & Kendler, 2003 source
- May combine two claims. 35
- Classified as probably not a substantial claim. 15
- The quote only partly states this claim. 1
May combine two claims.
PremisecitationIn a waitlist-controlled trial, 78% of treated participants no longer met criteria for GAD and 77% achieved high end-state functioning at posttreatment.
“a waitlist-controlled trial showed 78% of treated participants no longer met criteria for GAD and 77% achieved high end-state functioning at posttreatment (Roemer, Orsillo, & Salters-Pedneault, 2008).”
Quote in the paperSubstantial claim1 of 1 sources checked- cites Roemer, Orsillo, & Salters-Pedneault, 2008 source
The Results (Controlled Trial; page unavailable) report that 76.92% of treated participants no longer met GAD criteria at post-treatment, not 78%. The Discussion (page unavailable) reports that 77% of the treated sample achieved high end-state functioning at post-assessment. Thus the trial and the second percentage are supported, but the first percentage does not match the reported controlled-trial result. (LLM, conf=0.84)
Experimental — accuracy not yet measured
May combine two claims.
Findingown dataIn this sample, both ABBT and NDST led to medium to high effect size changes at both posttreatment and 3-month follow-up.
“In this sample, both ABBT and NDST led to medium to high effect sizes changes at both posttreatment and 3-month follow-up time points.”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataFor the PSWQ, there was a significant Time × Treatment effect, but not main effects of Time or Treatment.
“Similarly, there was a significant Time × Treatment effect for the PSWQ, but not main effects of Time or Treatment”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataFor DASS-anxiety, there was a main effect for time, but nonsignificant effects for Treatment or the Time × Treatment effect.
“For the DASS-anxiety, there was a main effect for time, but nonsignificant effects for Treatment or the Time × Treatment effect”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataFor DASS-depression and WHOQOL-physical, there were significant effects of Time and near significant Treatment × Time effects (p = .059 and p = .056), indicating scores increased on DASS-depression and decreased on WHOQOL-physical from posttreatment to follow-up.
“Similarly, for the DASS-depression and WHOQOL-physical, there were significant effects of Time and a near significant (p = .059and p = .056,respectively) Treatment × Time effect, indicating that scores increased on average on the DASS-depression and decreased on average on the”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataABBT showed more rapid results than NDST in clinical global impressions (severity and improvement), worry, anxiety (HAM-A), stress, and the physical domain of quality of life.
“Nevertheless, ABBT showed more rapid results than the control group (NDST) in clinical global impressions (severity and improvement), worry, anxiety (HAM-A), stress, and the physical domain of quality of life.”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataFor pretreatment to follow-up, effect sizes ranged from 0.74 to 1.45 for ABBT and 0.25 to 0.95 for NDST.
“for the pretreatment to follow-up assessment, d's ranged from 0.74 to 1.45 for ABBT and 0.25-0.95for NDST.”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataFor the psychological subscale of the WHOQOL, there were significant effects of Time and Treatment × Time, indicating scores decreased on average from posttreatment to follow-up and that this decrease was driven by NDST.
“there were significant effects of Time and Treatment × Time on the psychological subscale of the WHOQOL, indicating that scores decreased on average from posttreatment to follow-up and that this decrease was driven by those in the NDST condition.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingown dataThere was a nonsignificant trend for the Treatment × Time effect for DASS-depression in the direction of ABBT having a more rapid decrease than NDST.
“There was also a nonsignificant trend for the Treatment × Time effect for the DASS-depression in the direction of those in ABBT having a more rapid decrease than those in NDST.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataThe MRM models for DASS-stress, HAMA, CGI-S, and CGI-I showed a significant effect for Time and the Time × Treatment effect, but not for the Treatment main effect.
“The MRM models for DASS-stress, HAMA, CGI-S, and CGI-I showed a significant effect for Time and the Time × Treatment effect, but not for the Treatment main effect”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataThere was a near significant (p = .058) effect for Treatment on the psychological subscale of the WHOQOL, indicating that those in ABBT had higher scores throughout the study.
“Of note, there was a near significant (p = .058)effect for Treatment on the psychological subscale of the WHOQOL, indicating that those in ABBT had higher scores on the WHOQOL-psychological subscale throughout the study.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataFor DASS-depression and the psychological and social subscales of the WHOQOL, there were not significant Time, Treatment, or Time × Treatment effects.
“for the MRM models for DASS-depression and the psychological and social subscales of the WHOQOL, there were not significant Time, Treatment, or Time × Treatment effects.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataThere was a Time × Treatment effect for CGI-S and a trend level effect for CGI-I, indicating better maintenance of general clinical gains for ABBT.
“There was also a Time × Treatment effect for CGI-S and a trend level effect for CGI-I, indicating better maintenance of general clinical gains for ABBT”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataFor pretreatment to posttreatment, effect sizes ranged from 0.80 to 1.49 for ABBT and 0.41 to 1.19 for NDST.
“for the pretreatment to posttreatment assessment, d's ranged from 0.80 to 1.49 for the ABBT condition and 0.41-1.19for the NDST condition.”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataThere was a significant effect of Time on DASS-stress and CGI-I, indicating that scores increased on average from posttreatment to follow-up.
“there was a significant effect of Time on the DASS-stress and CGI-I, indicating that scores increased on average from posttreatment to follow-up”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataThere were no differences in change between groups from pretreatment to posttreatment in any secondary measure except physical quality of life, which was better in ABBT.
“Regarding secondary outcome measures, there were no differences in change between groups from pretreatment to posttreatment in any secondary measure but the physical quality of life, which was better in ABBT.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataUsing MRM analysis, ABBT outperformed NDST in all outcome measures except DASS-anxiety: HAMA, PSWQ, CGI-I, CGI-S, and DASS-stress.
“Using MRM analysis, ABBT outperformed NDST in all but one outcome measure: HAMA, PSWQ, CGI-I, CGI-S, DASS-stress, but not DASS-anxiety.”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataAltogether, these data indicate that symptoms decreased in both conditions across treatment and follow-up, and that the rate of change was more rapid for those participants in the ABBT condition.
“Altogether, these data indicate that symptoms decreased in both conditions across treatment and follow-up, and that the rate of change was more rapid for those participants in the ABBT condition.”
Quote in the paperSubstantial claimMay combine two claims.
FindingcitationABBT showed large within-group effect sizes for all outcome measures at all assessment points, except for DASS-anxiety, which had a medium effect size at follow-up (d = 0.74).
“Using the parameters suggested by Cohen (1988) for withingroup effect sizes, ABBT showed large effect sizes for all outcome measures at all assessment points, except for DASS-anxiety, for which there was a medium effect size at follow-up (d = 0.74).”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Cohen (1988)
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
May combine two claims.
Findingown dataNeither group in our study maintained all the gains obtained, even though it was not statistically significant.
“In addition, even though it was not statistically significant, neither group in our study maintained all the gains obtained.”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataWe found no differences between groups from pretreatment to posttreatment in DASS-anxiety or any secondary outcome measure, but for the physical health domain of WHOQOL, which was faster in ABBT.
“We found no differences between groups from pretreatment to posttreatment in DASS-anxiety or any secondary outcome measure, but for the physical health domain of WHOQOL, which was faster in ABBT.”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataFor NDST, there were large effect sizes for DASS-stress and CGI-S at posttreatment, and for HAM-A at posttreatment and follow-up; a medium effect size for DASS-anxiety at posttreatment and for CGI-S at follow-up; and small effect sizes for PSWQ at posttreatment and follow-up, and for DASS-stress and DASS-anxiety at follow-up.
“For NDST, there were large effect sizes for DASS-stress and CGI-S at posttreatment, and for HAM-A at posttreatment and follow-up; a medium effect size for DASS-anxiety at posttreatment and for CGI-S at follow-up; and small effect sizes for PSWQ at posttreatment and follow-up, and for DASS-stress and DASS-anxiety at follow-up.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataNo differences were found on DASS-anxiety, DASS-depression, and the psychological and social domains of WHOQOL.
“But no differences were found on DASS-anxiety, DASS-depression, and on the psychological and social domains of WHOQOL.”
Quote in the paperSubstantial claimMay combine two claims.
FindingcitationOur data show a relatively high dropout rate, but it was no different from that found in clinical trials of group CBT for anxiety disorders.
“Although our data show a relatively high dropout rate, it was no different from that found in clinical trials of group CBT for anxiety disorders (see Fernandez, Salem, Swift, & Ramtahal, 2015;Issakidis & Andrews, 2004, for a review).”
Quote in the paperNot a substantial claim0 of 2 sources checkedMay combine two claims.
Findingown dataDepressive symptom reductions did not achieve large effect sizes in either group, though the ABBT group showed a trend for better performance.
“Moreover, depressive symptom reductions did not achieve large effect sizes in either group, even though the ABBT group showed a trend for better performance.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationExposure techniques show good results in clinical and translational research.
“exposure techniques show good results in clinical and translational research (e.g., Fracalanza, Koerner, & Antony, 2014;Goldman, Dugas, Sexton, & Gervais, 2007)”
Quote in the paperNot a substantial claim0 of 2 sources checkedClassified as probably not a substantial claim.
PremisecitationDelivering psychoeducation and a similarly compelling treatment rationale in both conditions is important to control for differences in expectancy for success.
“Delivering psychoeducation and a similarly compelling treatment rationale in both conditions is important to control for differences in expectancy for success, which has been demonstrated to be a driver of change in psychotherapy (Weinberger & Rasco, 2007).”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Weinberger & Rasco, 2007
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
The quote only partly states this claim.
Study design and conductown dataThe chi-square test showed a significant difference between groups in dropout (p = .01).
“The chi-square test showed a significant difference between groups (p = .01).”
Quote in the paperNot a substantial claimMay combine two claims.
Study design and conductown dataThere were no pretreatment differences between groups on any primary outcome variables and the majority of secondary outcome variables.
“There were no pretreatment differences between groups on any primary outcome variables and the majority of secondary outcome variables: DASS-anxiety [F(1, 90) = 1.16; p = .28],DASS-stress”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Study design and conductcitationRandomization used randomly permuted blocks and was stratified into two blocks by use of psychotropic medication.
“we randomized each of them to a single treatment by using the method of randomly permuted blocks (Matts & Lachin, 1988).Randomization was stratified into two blocks by the use of psychotropic medication”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Matts & Lachin, 1988 source
May combine two claims.
PremisecitationIn an open trial, 16 treated patients demonstrated significant reductions in clinician-rated severity of GAD and reports of anxiety symptoms.
“In an open trial, 16 treated patients demonstrated significant reductions in clinician-rated severity of GAD and reports of anxiety symptoms (Roemer & Orsillo, 2007).”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Roemer & Orsillo, 2007 source
Probably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductown dataNo participants from either group reported changing medicine dosage or seeking additional treatment during the study period.
“No participants from either group reported changing medicine dosage or seeking adittional treatment during the study period.”
Quote in the paperNot a substantial claimClassified as probably not a substantial claim.
Study design and conductcitationPrimary analyses compared treatment differences over time in the intent-to-treat sample using mixed-effects regression models.
“The primary analyses compared treatment differences over time in the intent-to-treat sample for ABBT and NDST using mixed-effects regression models (MRM) in SPSS Version 23.0 (Hedeker & Gibbons, 2006).”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Hedeker & Gibbons, 2006 source
May combine two claims.
Study design and conductown dataThe majority of NDST participants dropped out before the midtreatment evaluation at Week 6 (n = 19 or 41.6%), and the dropout rate after Week 6 was relatively low (n = 4 or 8.7%).
“The majority of NDST participants dropped out before the midtreatment evaluation at Week 6 (n = 19 or 41.6%), and the dropout rate after Week 6 was relatively low (n = 4 or 8.7%).”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductown dataThere were five instances of forbidden interventions in three NDST sessions.
“However, there were five instances of forbidden interventions (i.e., directive-like interventions) in three NDST sessions.”
Quote in the paperNot a substantial claimMay combine two claims.
Study design and conductown dataThere were no forbidden strategies in the ABBT sessions, and 92 (86.8%) required interventions were rated as satisfactorily present.
“There were no forbidden strategies in the ABBT sessions, and 92 (86.8%) required interventions were rated as satisfactorily present.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductown dataInterrater reliability assessment showed 100% diagnosis concordance among all eight evaluators.
“We assessed interrater reliability through evaluations of one recorded interview showing 100% of diagnosis concordance among all the eight evaluators.”
Quote in the paperNot a substantial claimClassified as probably not a substantial claim.
PremisecitationNDST consists of an active form of therapy from which all intervention principles of specific psychotherapeutic protocols are removed while maintaining common factors.
“NDST consists of an active form of therapy from which all intervention principles of specific psychotherapeutic protocols are removed while maintaining the so-called common factors (Weinberger & Rasco, 2007).”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Weinberger & Rasco, 2007
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
Probably not a substantial claim: may not pass S4 (based).
Interpretationnone givenTo our knowledge, this is the first report on the efficacy of a group ABBT based on Roemer and Orsillo's model for the treatment of GAD.
“To our knowledge, this is the first report on the efficacy of a group ABBT based on Romer and Orsillo's model for the treatment of GAD.”
Quote in the paperNot a substantial claimMay combine two claims.
Study design and conductreasoningAll therapists who ran the NDST groups are CBT specialists, which raises the possibility of allegiance bias.
“All therapists who ran the NDST groups are CBT specialists, which raises the possibility of allegiance bias.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductown dataThe evaluators had at least 5 years of experience treating individuals with anxiety disorders and using the selected instruments.
“and had at least 5 years of experience treating individuals with anxiety disorders and using the selected instruments.”
Quote in the paperNot a substantial claimMay combine two claims.
Interpretationown dataThe protocols might have been too short and/or too rigid.
“This suggests that the protocols might have been too short and/or too rigid.”
Quote in the paperSubstantial claimClassified as probably not a substantial claim. May combine two claims.
Study design and conductreasoningWe privileged internal over external validity, using a very structured ABBT protocol and a rigorous selection of the sample and therapists.
“As is the case with most RCTs, we privileged internal over external validity, using a very structured ABBT protocol and a rigorous selection of the sample and therapists.”
Quote in the paperSubstantial claimMay combine two claims.
Interpretationown dataBoth groups showed good clinical outcomes, but in general, participants of the ABBT group improved faster than those in the NDST group.
“Both groups showed good clinical outcomes, but in general, participants of the ABBT group improved faster than those in the NDST group.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Study design and conductnone givenThe participants were randomly allocated to the evaluators and assessed by the same professional at all time points.
“The participants were randomly allocated to the evaluators and assessed by the same professional at all time points.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductreasoningBecause our protocol used several different components, such as psychoeducation, mindfulness practices, imaginal exposure, values clarification, and committed action, we cannot comment on the differential impact of each of these components on clinical outcome and attrition.
“Because our protocol used several different components, such as psychoeducation, mindfulness practices, imaginal exposure, values clarification, and committed action, we cannot comment on the differential impact of each of these components on clinical outcome and attrition.”
Quote in the paperNot a substantial claimClassified as probably not a substantial claim.
Study design and conductnone givenThe evaluators were masked to any information about the participants' group allocation.
“The evaluators were masked to any information about the participants' group allocation”
Quote in the paperSubstantial claimMay combine two claims.
Interpretationown dataA group ABBT protocol adding willingness-based exposure to traditional acceptance-based interventions is a feasible and efficacious treatment option for GAD.
“These findings suggest that a group ABBT protocol adding willingnessbased exposure to traditional acceptance-based interventions is a feasible and efficacious treatment option for GAD.”
Quote in the paperSubstantial claim
The paper relies on this without support.
Willingness-focused exposure has not been tested in a GAD treatment protocol.
“However, such willingness-focused exposure has not been tested in a GAD treatment protocol.”
The paper relies on this without support.
Environmental characteristics were not supposed to change with any of the psychological interventions used in the study.
“In this study, we analyzed only the first three domains, because environmental characteristics were not supposed to change with any of the psychological interventions we made.”
The authors state this as an assumption.
The hierarchical linear models have random intercepts and slopes and an unstructured covariance matrix.
“We ran models assuming random intercepts and slopes and with an unstructured covariance matrix.”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The study was a parallel-arm randomized controlled trial that investigated the effect of ABBT on a variety of clinical symptoms compared to supportive therapy in GAD patients.
“Subjects in this study took part in a parallel-arm RCT that investigated the effect of ABBT on a variety of clinical symptoms compared to ST in GAD patients (de Almeida Sampaio et al., 2020) (Clinical Trials identifier NCT03930095).”
From Inflammatory markers changes following acceptance-based behavioral psychotherapy in generalized anxiety disorder patients: Evidence from a randomized controlled trial (2024) · cites this paper as de Almeida Sampaio et al., 2020
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
Each contradiction between two passages listed here was confirmed by an independent check.
NDST depression effect size has a misplaced decimal
MinorThe discussion calls the NDST follow-up depression effect size 0.9, whereas Table 7 reports 0.09. The reported value also conflicts with the description of that effect as very small.
“from medium to "very small" (d = 0.9) for depressive symptoms.”
“WHOQOL-social 0.42 0.12 DASS-depression 0.60 0.09”
NDST follow-up effect-size maximum is misstated
MinorThe five primary-outcome NDST effect sizes at follow-up in Table 7 range from 0.25 to 0.88, not 0.95.
“for the pretreatment to follow-up assessment, d's ranged from 0.74 to 1.45 for ABBT and 0.25-0.95for NDST.”
“Pretreatment to follow-up DASS-anxiety 0.74 0.49 DASS-stress 1.07 0.42 HAMA 1.40 0.88 PSWQ 0.96 0.25 CGI-S 1.45 0.68”
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Satisfação e qualidade de vida em psicoterapia: um estudo piloto em clínica-escola
Bacelar, T. D., de Figueredo-Campos, J. G., Lopes, F. C., & de Paula, J. J. (2020) · Revista Psicologia Diversidade e Saúde · doi:10.17267/2317-3394rpds.v9i3.3217 · Cited by 1 · see citing works
O lugar dos ensaios clínicos aleatorizados na pesquisa em psicoterapia: uma crítica epistemológica
Sampaio, T. P. D. A., & Neto, F. L. (2021) · Psicologia USP · doi:10.1590/0103-6564e200015 · Cited by 1 · see citing works
Self-citationHayes-Skelton, S. A., Roemer, L., & Orsillo, S. M. (2025) · Cognitive Behaviour Therapy · doi:10.1080/16506073.2024.2417423
“In looking at longer an open trial (Roemer & Orsillo, 2007), a waitlist RCT (Roemer et al., 2008), and comparative efficacy trials with supportive therapy (de Almeida Sampaio et al., 2020), applied relaxation (Hayes-Skelton et al., 2013), and cognitive-behavioral therapy (Vera et al., 2021).”
Self-citationMartins, D. S., Sampaio, T. P. D. A., & Lotufo Neto, F. (2022) · Jornal Brasileiro de Psiquiatria · doi:10.1590/0047-2085000000361
Self-citationMartins, D. S. (2020) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.47.2020.tde-02092020-174154
Self-citationGandarela, L. M. (2021) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2021.tde-08122021-140003
Self-citationA Terapia Focada em Esquemas na prática clínica on-line no Brasil
Giustina, A. A. D. (2023) · doi:10.11606/d.47.2023.tde-12092023-161027
Sun, X., Zhang, L., Pan, Y., Ni, K., Ji, C., Zhou, Q., Stuart, S. P., & Luo, Y. (2025) · Clinics · doi:10.1016/j.clinsp.2025.100664
“37 As CBT is considered the “ golden standard ” and first-line psychotherapy for GAD, Simona Stefan et al. 38 conducted a randomized clinical trial to compare three CBT protocols for GAD: a) Cognitive Therapy/Borkovec ’ s treatment package, b) Rational Emotive Behavior Therapy, and c) Acceptance…”
Roemer, L., Eustis, E. H., & González-Garzón, A. M. (2025) · CBT: science into practice · doi:10.1007/978-3-031-91439-3_12
Gandarela, L. M., Sampaio, T. P. D. A., Marçal, L., Burdmann, E. A., Neto, F. L., & Bernik, M. (2026) · BMC Psychiatry · doi:10.1186/s12888-026-08027-8
“The results of the controlled clinical trial have already been published elsewhere [13] (Clinical Trials identifier NCT03930095).”
InfluentialSelf-citationAcceptance and Commitment Therapy for Generalized Anxiety Disorder: A Narrative Review
Capel, L. K., Knudsen, F. M., Thomas, G., Levin, M. E., & Twohig, M. P. (2026) · Behavior Modification · doi:10.1177/01454455261449755
“Almeida Sampaio et al. (2020) evaluated group-based ACT compared to group nondirective supportive therapy (NDST) in 92 adults diagnosed with GAD using the MINI.”
da Silva, M. T., Dutra, L. B., Maus, D., de Santana, P. C., Romão, P. R. T., Skupien, J., & Boeck, C. R. (2026) · Pharmacology, Biochemistry and Behavior · doi:10.1016/j.pbb.2026.174228
Borthwick, C., Norton, A., Trenoska Basile, V., & Wootton, B. (2026) · British Journal of Clinical Psychology · doi:10.1111/bjc.70089
Sampaio, T. P. D. A., Jansson‐Fröjmark, M., Martins, D. S., Lundgren, T., Hayes‐Skelton, S. A., & Neto, F. L. (2026) · Jornal Brasileiro de Psiquiatria · doi:10.1590/0047-2085-2025-0069
Self-citation
- Authors
- Almeida Sampaio, T. P., Jorge, R. C., Martins, D. S., Gandarela, L. M., Hayes‐Skelton, S., Bernik, M. A., & Lotufo‐Neto, F.
- Affiliations
- Department of Clinical Psychology, Institute of Psychology University of São Paulo São Paulo Brazil
- Universidade de São Paulo (BR)
- University of Massachusetts Boston (US)
- ORCID
- Venue
- Depression and Anxiety
- Publisher
- Wiley
- Published
- 2020-04-25
- Volume
- 37
- Issue
- 12
- Pages
- 1179-1193
- ISSN
- 1091-4269 (ISSN-L)
- 1520-6394
- OpenAlex
- W3019666597
- Cited by
- 23
- References
- 87
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 4 · 2020: 2
- FWCI
- 2.90
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Depression and Anxiety (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Keywords
- generalized anxiety disorder, mindfulness, exposure therapy, quality of life, worry, stress, depression
- MeSH terms
- Anxiety Disorders, Brazil, Humans, Psychotherapy, Group, Quality of Life, Treatment Outcome
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