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Alanine aminotransferase as a marker of non‐alcoholic fatty liver disease in relation to type 2 diabetes mellitus and cardiovascular disease

Schindhelm, Roger K., Diamant, Michaela, Dekker, Jacqueline M., Tushuizen, Maarten E., Teerlink, Tom, Heine, Robert J.·2006·Diabetes/Metabolism Research and Reviews

DOI 10.1002/dmrr.666

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Abstract

For a long time, hepatic steatosis was believed to be a benign condition. Only recently, liver steatosis, also termed non‐alcoholic fatty liver disease(NAFLD), has gained much interest. In most cases of NAFLD, a condition regarded as the hepatic component of the metabolic syndrome, the enzyme alanine aminotransferase (ALT) is elevated and consequently has been used as a marker for NAFLD. More recently, several cross‐sectional and prospective studies have demonstrated associations of this liver enzyme with features of the metabolic syndrome and type 2 diabetes mellitus. This review discusses the biochemical and metabolic properties of ALT, its applicability as a marker of NAFLD and describes its possible role in the pathogenesis of the metabolic syndrome and type 2 diabetes mellitus and subsequent cardiovascular disease. In addition, treatment strategies to ameliorate NAFLD and the associated risks are discussed. Copyright © 2006 John Wiley & Sons, Ltd.

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See all 375

Authors: Schindhelm, R. K., Diamant, M., Dekker, J. M., Tushuizen, M. E., Teerlink, T., & Heine, R. J.
Venue: Diabetes/Metabolism Research and Reviews
Publisher: Wiley
Published: 2006-07-11
Volume: 22
Issue: 6
Pages: 437-443
ISSN: 1520-7552 (ISSN-L)
1520-7560
DOI: 10.1002/dmrr.666
OpenAlex: W2040874495
Cited by: 375
References: 70
FWCI: 14.39
Type: journal article
Language: en
Open access: closed

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Alanine aminotransferase as a marker of non‐alcoholic fatty liver disease in relation to type 2 diabetes mellitus and cardiovascular disease

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