The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
The molecular regulation of arteriovenous specification and maintenance
Open accessAbstract
The formation of a hierarchical vascular network, composed of arteries, veins, and capillaries, is essential for embryogenesis and is required for the production of new functional vasculature in the adult. Elucidating the molecular mechanisms that orchestrate the differentiation of vascular endothelial cells into arterial and venous cell fates is requisite for regenerative medicine, as the directed formation of perfused vessels is desirable in a myriad of pathological settings, such as in diabetes and following myocardial infarction. Additionally, this knowledge will enhance our understanding and treatment of vascular anomalies, such as arteriovenous malformations (AVMs). From studies in vertebrate model organisms, such as mouse, zebrafish, and chick, a number of key signaling pathways have been elucidated that are required for the establishment and maintenance of arterial and venous fates. These include the Hedgehog, Vascular Endothelial Growth Factor (VEGF), Transforming Growth Factor‐β (TGF‐β), Wnt, and Notch signaling pathways. In addition, a variety of transcription factor families acting downstream of, or in concert with, these signaling networks play vital roles in arteriovenous (AV) specification. These include Notch and Notch‐regulated transcription factors (e.g., HEY and HES), SOX factors, Forkhead factors, β‐Catenin, ETS factors, and COUP‐TFII. It is becoming apparent that AV specification is a highly coordinated process that involves the intersection and carefully orchestrated activity of multiple signaling cascades and transcriptional networks. This review will summarize the molecular mechanisms that are involved in the acquisition and maintenance of AV fate, and will highlight some of the limitations in our current knowledge of the molecular machinery that directs AV morphogenesis. Developmental Dynamics 244:391–409, 2015. © 2015 Wiley Periodicals, Inc.
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Cites
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“Considering the widespread presence of GGA(A/T) motifs throughout the genome, how diverse members of the ETS family bind and regulate their common and/or specific target genes in ECs during vascular development remains poorly understood (Wei et al., 2010).”
BackgroundSpatial and temporal patterns of ERK signaling during mouse embryogenesis
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Ets1 and ets2 are required for endothelial cell survival during embryonic angiogenesis
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Background
Cited by
Vascular endothelial cell development and diversity
Trimm, E., & Red-Horse, K. (2023) · Nature Reviews Cardiology · doi:10.1038/s41569-022-00770-1 · Cited by 537
Blood flow controls bone vascular function and osteogenesis
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TGF-β Signaling in Control of Cardiovascular Function
Goumans, M.-J., & ten Dijke, P. (2018) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a022210 · Cited by 360
Endothelial-Specific Cre Mouse Models: Is Your Cre CREdibile?
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Coordination of endothelial cell positioning and fate specification by the epicardium
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Metadata
- Authors
- Fish, J. E., & Wythe, J. D.
- Venue
- Developmental Dynamics
- Publisher
- Wiley
- Published
- 2015-02-26
- Volume
- 244
- Issue
- 3
- Pages
- 391-409
- ISSN
- 1058-8388 (ISSN-L)
- 1097-0177
- OpenAlex
- W1596750122
- Cited by
- 164
- References
- 11
- FWCI
- 6.69
- Type
- journal article
- Language
- en
- Open access
- bronze
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