The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Antigen presentation and tumor cytotoxicity by interferon‐γ‐treated microglial cells
Abstract
In this study microglial cells isolated from brain cell cultures of newborn mice were characterized and investigated for morphology, their responses to growth factors and their functional properties. The microglial cells were phagocytic, contained nonspecific esterase activity and expressed Fc (IgG 1/2b) and type‐3 complement receptors. Scanning electron microscopy revealed that in analogy to brain tissue two types of microglial cells are present in the cultures: the ameboid and the ramified type which both display similar appearance by transmission electron microscopy. Interleukin 3 and the granulocyte‐macrophage colony‐stimulating factor were potent growth factors for the cultured microglial cells. The cells were negative for class II antigens (Ia) of the major histocompatibility antigen complex. However, upon treatment with interferon‐γ (IFN‐γ) microglial cells became Ia+ and functioned as antigen‐presenting cells when tested on ovalbumin‐specific Ia‐restricted helper T cells. Furthermore, microglial cells exposed to IFN‐γ and endotoxin developed tumor cell cytotoxicity and produced tumor necrosis factor α. Taken together, microglial cells share the characteristics of cells of the macrophage lineage.
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Cites
An endotoxin-induced serum factor that causes necrosis of tumors
Carswell, E. A., Old, L. J., Kassel, R. L., Green, S., Fiore, N., & Williamson, B. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.9.3666 · Cited by 4,532
Perry, V. H., Hume, D. A., & Gordon, S. (1985) · Neuroscience · doi:10.1016/0306-4522(85)90215-5 · Cited by 902
Cited by
Microglia: a sensor for pathological events in the CNS
Kreutzberg, G. W. (1996) · Trends in Neurosciences · doi:10.1016/0166-2236(96)10049-7 · Cited by 4,396
Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth
Zhang, L., Zhang, S., Yao, J., Lowery, F. J., Zhang, Q., Huang, W.-C., Li, P., Li, M., Wang, X., Zhang, C., et al. (2015) · Nature · doi:10.1038/nature15376 · Cited by 1,175
Streit, W. J., Walter, S. A., & Pennell, N. A. (1999) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00069-0 · Cited by 1,096
Mogi, M., Harada, M., Riederer, P., Narabayashi, H., Fujita, K., & Nagatsu, T. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90746-3 · Cited by 986
Microglial-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death
Boje, K. M., & Arora, P. K. (1992) · Brain Research · doi:10.1016/0006-8993(92)91004-x · Cited by 944
Metadata
- Authors
- Frei, K., Siepl, C., Groscurth, P., Bodmer, S., Schwerdel, C., & Fontana, A.
- Venue
- European Journal of Immunology
- Publisher
- Wiley
- Published
- 1987-01
- Volume
- 17
- Issue
- 9
- Pages
- 1271-1278
- ISSN
- 0014-2980 (ISSN-L)
- 1521-4141
- OpenAlex
- W2064329226
- Cited by
- 642
- References
- 2
- FWCI
- 18.46
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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