The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Antigen presentation and tumor cytotoxicity by interferon‐γ‐treated microglial cells
Abstract
In this study microglial cells isolated from brain cell cultures of newborn mice were characterized and investigated for morphology, their responses to growth factors and their functional properties. The microglial cells were phagocytic, contained nonspecific esterase activity and expressed Fc (IgG 1/2b) and type‐3 complement receptors. Scanning electron microscopy revealed that in analogy to brain tissue two types of microglial cells are present in the cultures: the ameboid and the ramified type which both display similar appearance by transmission electron microscopy. Interleukin 3 and the granulocyte‐macrophage colony‐stimulating factor were potent growth factors for the cultured microglial cells. The cells were negative for class II antigens (Ia) of the major histocompatibility antigen complex. However, upon treatment with interferon‐γ (IFN‐γ) microglial cells became Ia+ and functioned as antigen‐presenting cells when tested on ovalbumin‐specific Ia‐restricted helper T cells. Furthermore, microglial cells exposed to IFN‐γ and endotoxin developed tumor cell cytotoxicity and produced tumor necrosis factor α. Taken together, microglial cells share the characteristics of cells of the macrophage lineage.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
An endotoxin-induced serum factor that causes necrosis of tumors
Carswell, E. A., Old, L. J., Kassel, R. L., Green, S., Fiore, N., & Williamson, B. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.9.3666 · Cited by 4,532
Perry, V. H., Hume, D. A., & Gordon, S. (1985) · Neuroscience · doi:10.1016/0306-4522(85)90215-5 · Cited by 902
Cited by
Microglia: a sensor for pathological events in the CNS
Kreutzberg, G. W. (1996) · Trends in Neurosciences · doi:10.1016/0166-2236(96)10049-7 · Cited by 4,396
Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth
Zhang, L., Zhang, S., Yao, J., Lowery, F. J., Zhang, Q., Huang, W.-C., Li, P., Li, M., Wang, X., Zhang, C., et al. (2015) · Nature · doi:10.1038/nature15376 · Cited by 1,175
Streit, W. J., Walter, S. A., & Pennell, N. A. (1999) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00069-0 · Cited by 1,096
Mogi, M., Harada, M., Riederer, P., Narabayashi, H., Fujita, K., & Nagatsu, T. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90746-3 · Cited by 986
Microglial-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death
Boje, K. M., & Arora, P. K. (1992) · Brain Research · doi:10.1016/0006-8993(92)91004-x · Cited by 944
Microglia as neuroprotective, immunocompetent cells of the CNS
Streit, W. J. (2002) · Glia · doi:10.1002/glia.10154 · Cited by 919
Tumor necrosis factor alpha: A link between neuroinflammation and excitotoxicity
Olmos, G., & Lladó, J. (2014) · Mediators of Inflammation · doi:10.1155/2014/861231 · Cited by 730
The interplay of fibroblasts, the extracellular matrix, and inflammation in scar formation
Moretti, L., Stalfort, J., Barker, T. H., & Abebayehu, D. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.101530 · Cited by 393
Microglial cell population dynamics in the injured adult central nervous system
Ladeby, R., Wirenfeldt, M., Garcia-Ovejero, D., Fenger, C., Dissing-Olesen, L., Dalmau, I., & Finsen, B. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.12.009 · Cited by 334
Control of glial immune function by neurons
Neumann, H. (2001) · Glia · doi:10.1002/glia.1108 · Cited by 319
Microglial Recruitment, Activation, and Proliferation in Response to Primary Demyelination
Remington, L. T., Babcock, A. A., Zehntner, S. P., & Owens, T. (2007) · The American Journal of Pathology · doi:10.2353/ajpath.2007.060783 · Cited by 234
Hayashi, M., Luo, Y., Laning, J., Strieter, R. M., & Dorf, M. E. (1995) · Journal of Neuroimmunology · doi:10.1016/0165-5728(95)00064-9 · Cited by 226
Olson, J. K., Girvin, A. M., & Miller, S. D. (2001) · Journal of Virology · doi:10.1128/jvi.75.20.9780-9789.2001 · Cited by 178
The microglia in healthy and diseased retina
Li, L., Eter, N., & Heiduschka, P. (2015) · Experimental Eye Research · doi:10.1016/j.exer.2015.04.020 · Cited by 112
Walker, W. S., Gatewood, J., Olivas, E., Askew, D., & Havenith, C. E. G. (1995) · Journal of Neuroimmunology · doi:10.1016/0165-5728(95)00146-8 · Cited by 91
Interleukin-1 Enhances the ATP-Evoked Release of Arachidonic Acid from Mouse Astrocytes
Stella, N., Estellés, A., Siciliano, J., Tencé, M., Desagher, S., Piomelli, D., Glowinski, J., & Prémont, J. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-09-02939.1997 · Cited by 85
Intracerebroventricular injection of TNF-α promotes sleep and is recovered in cervical lymph
Dickstein, J. B., Moldofsky, H., Lue, F. A., & Hay, J. B. (1999) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1999.276.4.r1018 · Cited by 54
Ramilo, O. (1990) · Archives of Pediatrics & Adolescent Medicine · doi:10.1001/archpedi.1990.02150270099034 · Cited by 51
Sasaki, A., Yokoo, H., Naito, M., Kaizu, C., Shultz, L. D., & Nakazato, Y. (2000) · Neuropathology · doi:10.1046/j.1440-1789.2000.00286.x · Cited by 37
Salemi, J., Obregon, D. F., Cobb, A., Reed, S., Sadic, E., Jin, J., Fernandez, F., Tan, J., & Giunta, B. (2011) · Molecular Neurodegeneration · doi:10.1186/1750-1326-6-3 · Cited by 28
Metadata
- Authors
- Frei, K., Siepl, C., Groscurth, P., Bodmer, S., Schwerdel, C., & Fontana, A.
- Venue
- European Journal of Immunology
- Publisher
- Wiley
- Published
- 1987-01
- Volume
- 17
- Issue
- 9
- Pages
- 1271-1278
- ISSN
- 0014-2980 (ISSN-L)
- 1521-4141
- OpenAlex
- W2064329226
- Cited by
- 642
- References
- 2
- FWCI
- 18.46
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
