The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Induction of the interleukin 1 receptor antagonist protein by transforming growth factor‐β
Abstract
Transforming growth factor‐β1 (TGF‐β1) mediates many immunosuppressive effects on immune cells and can inhibit the production of tumor necrosis factor and interleukin 1 (IL 1). However, TGF‐β1 can stimulate the production of IL6 and platelet‐derived growth factor, indicating that TGF‐β1 initiates complex effects on the production of cytokines. In this report we show that treatment of peripheral blood monocytes with TGF‐β1 leads to the induction of a recently described IL1 receptor antagonist protein (IRAP). The effect of TGF‐β was both dose and time dependent. TGF‐β1 induced de novo synthesis of IRAP, as Northern blotting experiments indicated a rapid and transient induction of the mRNA encoding IRAP. The induction of IRAP suggests a potential mechanism by which some of the inhibitory effects of TGF‐β1 are mediated.
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Cites
Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor
Hannum, C. H., Wilcox, C. J., Arend, W. P., Joslin, F. G., Dripps, D. J., Heimdal, P. L., Armes, L. G., Sommer, A., Eisenberg, S. P., & Thompson, R. C. (1990) · Nature · doi:10.1038/343336a0 · Cited by 1,122
Carter, D. B., Deibel, M. R., Dunn, C. J., Tomich, C.-S. C., Laborde, A. L., Slightom, J. L., Berger, A. E., Bienkowski, M. J., Sun, F. F., McEwan, R. N., et al. (1990) · Nature · doi:10.1038/344633a0 · Cited by 601
Cited by
Tilg, H., Trehu, E., Atkins, M., Dinarello, C., & Mier, J. (1994) · Blood · doi:10.1182/blood.v83.1.113.113 · Cited by 817
Cytokines in Sepsis: Potent Immunoregulators and Potential Therapeutic Targets—An Updated View
Schulte, W., Bernhagen, J., & Bucala, R. (2013) · Mediators of Inflammation · doi:10.1155/2013/165974 · Cited by 745
Basic biology and role of interleukin‐17 in immunity and inflammation
Zenobia, C., & Hajishengallis, G. (2015) · Periodontology 2000 · doi:10.1111/prd.12083 · Cited by 470
Regulation of serum amyloid A protein expression during the acute-phase response
JENSEN, L. E., & WHITEHEAD, A. S. (1998) · Biochemical Journal · doi:10.1042/bj3340489 · Cited by 411
Cytokines and their receptors in the central nervous system: Physiology, pharmacology, and pathology
Rothwell, N. J., Luheshi, G., & Toulmond, S. (1996) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(95)02033-0 · Cited by 233
Metadata
- Authors
- Turner, M., Chantry, D., Katsikis, P., Berge, A., Brennan, F. M., & Feldmann, M.
- Venue
- European Journal of Immunology
- Publisher
- Wiley
- Published
- 1991-07
- Volume
- 21
- Issue
- 7
- Pages
- 1635-1639
- ISSN
- 0014-2980 (ISSN-L)
- 1521-4141
- OpenAlex
- W1964820926
- Cited by
- 163
- References
- 2
- FWCI
- 6.60
- Type
- journal article
- Language
- en
- Open access
- closed
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- Turner, M., Chantry, D., Katsikis, P., Berge, A., Brennan, F. M., & Feldmann, M. (1991). Induction of the interleukin 1 receptor antagonist protein by transforming growth factor‐β. European Journal of Immunology. https://doi.org/10.1002/eji.1830210708
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