The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
CD14lowCD16high: A cytokine‐producing monocyte subset which expands during human immunodeficiency virus infection
Abstract
Infection with the human immunodeficiency virus HIV‐1 is associated with the expansion of a CD14 low CD16 high monocyte subset in peripheral blood. This subset, which represents a minor subpopulation of monocytes in healthy individuals, increases during HIV infection and, in patients with AIDS, may represent up to 40% of the total circulating monocyte cell population. The CD14 low CD16 high circulating monocytes co‐express MAX.1, p150,95 and HLADR which are typical of tissue macrophage markers. These cells also express higher levels of intracellular interleukin (IL)‐1α and tumor necrosis factor (TNF)‐α than the CD14 high CD16 low monocyte population from the same patients. The CD14 low CD16 high cells also express low levels of CD35, CD11a and CD4 in common with normal monocytes. When cultured in vitro, monocytes from HIV‐seropositive individuals differentiated within a few hours into an elongated fibroblastoid shape characteristic of migratory cells. Our results suggest that the expansion of the CD14 low CD16 high monocyte subset, which produce high amounts of TNF‐α and IL‐1α, may participate in the immune dysfunction observed during HIV infection.
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Cites
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Cited by
Monocyte-Mediated Defense Against Microbial Pathogens
Serbina, N. V., Jia, T., Hohl, T. M., & Pamer, E. G. (2008) · Annual Review of Immunology · doi:10.1146/annurev.immunol.26.021607.090326 · Cited by 1,123
SuperSAGE evidence for CD14++CD16+ monocytes as a third monocyte subset
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Ancuta, P., Kamat, A., Kunstman, K. J., Kim, E.-Y., Autissier, P., Wurcel, A., Zaman, T., Stone, D., Mefford, M., Morgello, S., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002516 · Cited by 499
HIV‐associated chronic immune activation
Paiardini, M., & Müller‐Trutwin, M. (2013) · Immunological Reviews · doi:10.1111/imr.12079 · Cited by 451
Randolph, G. J., Sanchez-Schmitz, G., Liebman, R. M., & Schäkel, K. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20011608 · Cited by 357
Metadata
- Authors
- Thieblemont, N., Weiss, L., Sadeghi, H. M., Estcourt, C., & Haeffner‐Cavaillon, N.
- Venue
- European Journal of Immunology
- Publisher
- Wiley
- Published
- 1995-12
- Volume
- 25
- Issue
- 12
- Pages
- 3418-3424
- ISSN
- 0014-2980 (ISSN-L)
- 1521-4141
- OpenAlex
- W2047044941
- Cited by
- 296
- References
- 49
- FWCI
- 1.05
- Type
- journal article
- Language
- en
- Open access
- closed
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- Thieblemont, N., Weiss, L., Sadeghi, H. M., Estcourt, C., & Haeffner‐Cavaillon, N. (1995). CD14lowCD16high: A cytokine‐producing monocyte subset which expands during human immunodeficiency virus infection. European Journal of Immunology. https://doi.org/10.1002/eji.1830251232
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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