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Cited by 357

The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.

The CD16+ (FcγRIII+) Subset of Human Monocytes Preferentially Becomes Migratory Dendritic Cells in a Model Tissue Setting

Open access
Randolph, Gwendalyn J., Sanchez-Schmitz, Guzman, Liebman, Ronald M., Schäkel, Knut·2002·The Journal of Experimental Medicine
DOI 10.1084/jem.20011608
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Abstract

Much remains to be learned about the physiologic events that promote monocytes to become lymph-homing dendritic cells (DCs). In a model of transendothelial trafficking, some monocytes become DCs in response to endogenous signals. These DCs migrate across endothelium in the ablumenal-to-lumenal direction (reverse transmigration), reminiscent of the migration into lymphatic vessels. Here we show that the subpopulation of monocytes that expresses CD16 (Fcγ receptor III) is predisposed to become migratory DCs. The vast majority of cells derived from CD16+ monocytes reverse transmigrated, and their presence was associated with migratory cells expressing high levels of CD86 and human histocompatibility leukocyte antigen (HLA)-DR, and robust capacity to induce allogeneic T cell proliferation. A minority of CD16− monocytes reverse transmigrated, and these cells stimulated T cell proliferation less efficiently. CD16 was not functionally required for reverse transmigration, but promoted cell survival when yeast particles (zymosan) were present as a maturation stimulus in the subendothelial matrix. The cell surface phenotype and migratory characteristics of CD16+ monocytes were inducible in CD16− monocytes by preincubation with TGFβ1. We propose that CD16+ monocytes may contribute significantly to precursors for DCs that transiently survey tissues and migrate to lymph nodes via afferent lymphatic vessels.

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Metadata

Authors
Randolph, G. J., Sanchez-Schmitz, G., Liebman, R. M., & Schäkel, K.
Venue
The Journal of Experimental Medicine
Publisher
Rockefeller University Press
Published
2002-08-19
Volume
196
Issue
4
Pages
517-527
ISSN
  • 0022-1007 (ISSN-L)
  • 1540-9538
DOI
10.1084/jem.20011608
OpenAlex
W2142589355
Cited by
357
References
45
FWCI
6.66
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: The CD16+ (FcγRIII+) Subset of Human Monocytes Preferentially Becomes Migratory Dendritic Cells in a Model Tissue Setting. https://app.cochat.ai/papers/10.1084/jem.20011608
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Randolph, G. J., Sanchez-Schmitz, G., Liebman, R. M., & Schäkel, K. (2002). The CD16+ (FcγRIII+) Subset of Human Monocytes Preferentially Becomes Migratory Dendritic Cells in a Model Tissue Setting. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.20011608

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.