The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Regulatory T cells induce a privileged tolerant microenvironment at the fetal‐maternal interface
Open accessAbstract
The mechanisms underlying immune tolerance during pregnancy are poorly understood. In this regard, Treg seem to play an important role in mediating maternal tolerance to the fetus. We proposed a crucial role of T regulatory cells (Treg) in avoiding immunological rejection of the fetus after observing diminished number and function of Treg in abortion‐prone mice. We further confirmed the protective role of Treg during pregnancy by transferring pregnancy‐induced Treg into abortion‐prone mice, which prevented rejection. Here, we analyzed the mechanisms involved in Treg‐mediated protection. As expected, Treg therapy prevented abortion, while expanding the peripheral and thymic Treg population. Surprisingly, the decidual levels of the Th1 cytokines IFN‐γ and TNF‐α were not diminished after therapy. Interestingly, the mRNA levels of leukemia inhibitory factor, TGF‐β and heme oxygenase‐1 at the fetal‐maternal interface were dramatically up‐regulated after Treg transfer, while the levels of indolamine 2,3‐dioxygenase remained unchanged. Our data suggest that Treg treatment can not prevent T cell infiltration or high Th1 levels but is able to create a privileged tolerant microenvironment at the fetal‐maternal interface, further shedding light onto the molecular mechanisms involved in pregnancy tolerance.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Sakaguchi, S., Sakaguchi, N., Asano, M., Itoh, M., & Toda, M. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.3.1151 · Cited by 5,608
Sherwin, J. R. A., Freeman, T. C., Stephens, R. J., Kimber, S., Smith, A. G., Chambers, I., Smith, S. K., & Sharkey, A. M. (2004) · Molecular Endocrinology · doi:10.1210/me.2004-0110 · Cited by 68
Cited by
Immunology of placentation in eutherian mammals
Moffett, A., & Loke, C. (2006) · Nature Reviews Immunology · doi:10.1038/nri1897 · Cited by 836
Physiological and molecular determinants of embryo implantation
Zhang, S., Lin, H., Kong, S., Wang, S., Wang, H., Wang, H., & Armant, D. R. (2013) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.12.011 · Cited by 587
T cell receptor signalling in the control of regulatory T cell differentiation and function
Li, M. O., & Rudensky, A. Y. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.26 · Cited by 493
Immune resistance orchestrated by the tumor microenvironment
Gajewski, T. F., Meng, Y., Blank, C., Brown, I., Kacha, A., Kline, J., & Harlin, H. (2006) · Immunological Reviews · doi:10.1111/j.1600-065x.2006.00442.x · Cited by 437
Parker-Athill, E. C., & Tan, J. (2010) · Neurosignals · doi:10.1159/000319828 · Cited by 140
Metadata
- Authors
- Zenclussen, A. C., Gerlof, K., Zenclussen, M. L., Ritschel, S., Zambon Bertoja, A., Fest, S., Hontsu, S., Ueha, S., Matsushima, K., Leber, J., & Volk, H.
- Venue
- European Journal of Immunology
- Publisher
- Wiley
- Published
- 2005-12-27
- Volume
- 36
- Issue
- 1
- Pages
- 82-94
- ISSN
- 0014-2980 (ISSN-L)
- 1521-4141
- OpenAlex
- W2126011537
- Cited by
- 212
- References
- 2
- FWCI
- 4.29
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Regulatory T cells induce a privileged tolerant microenvironment at the fetal‐maternal interface. https://app.cochat.ai/papers/10.1002/eji.200535428
- The paper
- Zenclussen, A. C., Gerlof, K., Zenclussen, M. L., Ritschel, S., Zambon Bertoja, A., Fest, S., Hontsu, S., Ueha, S., Matsushima, K., Leber, J., & Volk, H. (2006). Regulatory T cells induce a privileged tolerant microenvironment at the fetal‐maternal interface. European Journal of Immunology. https://doi.org/10.1002/eji.200535428
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
