T cell receptor signalling in the control of regulatory T cell differentiation and function

Control of Regulatory T Cell Development by the Transcription Factor <i>Foxp3</i>

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Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

Fontenot, J. D., Gavin, M. A., & Rudensky, A. Y. (2003) · Nature Immunology · doi:10.1038/ni904 · Cited by 7,745 · see citing works

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

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Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases

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Regulatory T Cells and Immune Tolerance

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Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3

Chen, W., Jin, W., Hardegen, N. J., Lei, K.-J., Li, L., Marinos, N. J., McGrady, G., & Wahl, S. M. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030152 · Cited by 4,678 · see citing works

The Role of Tumoral FOXP3 on Cell Proliferation, Migration, and Invasion in Gastric Cancer

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Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota

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Regulatory T cells: mechanisms of differentiation and function

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An essential role for Scurfin in CD4+CD25+ T regulatory cells

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The clonal selection theory of acquired immunity

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Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription Factor

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Regulatory T Cell Lineage Specification by the Forkhead Transcription Factor Foxp3

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Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4

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PD-L1 regulates the development, maintenance, and function of induced regulatory T cells

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Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

Jordan, M. S., Boesteanu, A. C., Reed, A. J., Petrone, A. L., Holenbeck, A. E., Lerman, M. A., Naji, A., & Caton, A. J. (2001) · Nature Immunology · doi:10.1038/86302 · Cited by 1,661 · see citing works

Regulatory T cells mediate maternal tolerance to the fetus

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Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma

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mTOR differentially regulates effector and regulatory T cell lineage commitment

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Epigenetic Control of the foxp3 Locus in Regulatory T Cells

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Inducing and expanding regulatory T cell populations by foreign antigen

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Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate

Zheng, Y., Josefowicz, S. Z., Chaudhry, A., Peng, X. P., Forbush, K. A., & Rudensky, A. Y. (2010) · Nature · doi:10.1038/nature08750 · Cited by 1,170 · see citing works

Foxp3-dependent programme of regulatory T-cell differentiation

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Phenotypically distinct subsets of CD4 ⁺ T cells induce or protect from chronic intestinal inflammation in C. B-17 <i>scid</i> mice

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Interleukin-2 at the Crossroads of Effector Responses, Tolerance, and Immunotherapy

Liao, W., Lin, J., & Leonard, W. J. (2013) · Immunity · doi:10.1016/j.immuni.2013.01.004 · Cited by 1,077 · see citing works

Regulation and function of mTOR signalling in T cell fate decisions

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T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse

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Peripheral education of the immune system by colonic commensal microbiota

Lathrop, S. K., Bloom, S. M., Rao, S. M., Nutsch, K., Lio, C.-W., Santacruz, N., Peterson, D. A., Stappenbeck, T. S., & Hsieh, C.-S. (2011) · Nature · doi:10.1038/nature10434 · Cited by 1,034 · see citing works

TGF-β: A Master of All T Cell Trades

Li, M. O., & Flavell, R. A. (2008) · Cell · doi:10.1016/j.cell.2008.07.025 · Cited by 888 · see citing works

T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR

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Anti-CTLA-4 antibodies of IgG2a isotype enhance antitumor activity through reduction of intratumoral regulatory T cells

Selby, M. J., Engelhardt, J. J., Quigley, M., Henning, K. A., Chen, T., Srinivasan, M., & Korman, A. J. (2013) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-13-0013 · Cited by 857 · see citing works

Origin of regulatory T cells with known specificity for antigen

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All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation

Benson, M. J., Pino-Lagos, K., Rosemblatt, M., & Noelle, R. J. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070719 · Cited by 847 · see citing works

Maternal Alloantigens Promote the Development of Tolerogenic Fetal Regulatory T Cells in Utero

Mold, J. E., Michaëlsson, J., Burt, T. D., Muench, M. O., Beckerman, K., Busch, M. P., Lee, T., Nixon, D. F., & McCune, J. M. (2008) · Science · doi:10.1126/science.1164511 · Cited by 840 · see citing works

IL-2 Receptor β-Dependent STAT5 Activation Is Required for the Development of Foxp3+ Regulatory T Cells

Burchill, M. A., Yang, J., Vogtenhuber, C., Blazar, B. R., & Farrar, M. A. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.1.280 · Cited by 836 · see citing works

Extrathymically generated regulatory T cells control mucosal TH2 inflammation

Josefowicz, S. Z., Niec, R. E., Kim, H. Y., Treuting, P. M., Chinen, T., Zheng, Y., Umetsu, D. T., & Rudensky, A. Y. (2012) · Nature · doi:10.1038/nature10772 · Cited by 823 · see citing works

Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer

Tone, Y., Furuuchi, K., Kojima, Y., Tykocinski, M. L., Greene, M. I., & Tone, M. (2008) · Nature Immunology · doi:10.1038/ni1549 · Cited by 807 · see citing works

mTORC1 couples immune signals and metabolic programming to establish Treg-cell function

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The AKT–mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells

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T Cell Receptor Stimulation-Induced Epigenetic Changes and Foxp3 Expression Are Independent and Complementary Events Required for Treg Cell Development

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Organ-specific autoimmune diseases induced in mice by elimination of T cell subset. I. Evidence for the active participation of T cells in natural self-tolerance; deficit of a T cell subset as a possible cause of autoimmune disease.

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In Vivo Instruction of Suppressor Commitment in Naive T Cells

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Foxp3 + natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation

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The light and dark sides of intestinal intraepithelial lymphocytes

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A Two-Step Process for Thymic Regulatory T Cell Development

Lio, C. J., & Hsieh, C. (2008) · Immunity · doi:10.1016/j.immuni.2007.11.021 · Cited by 663 · see citing works

Homeostasis and anergy of CD4+CD25+ suppressor T cells in vivo

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The promise of low-dose interleukin-2 therapy for autoimmune and inflammatory diseases

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Extrathymic Generation of Regulatory T Cells in Placental Mammals Mitigates Maternal-Fetal Conflict

Samstein, R. M., Josefowicz, S. Z., Arvey, A. J., Treuting, P. M., & Rudensky, A. Y. (2012) · Cell · doi:10.1016/j.cell.2012.05.031 · Cited by 624 · see citing works

Developmental Stage, Phenotype, and Migration Distinguish Naive- and Effector/Memory-like CD4+ Regulatory T Cells

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Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells

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CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2

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CREB/ATF-dependent T cell receptor–induced FoxP3 gene expression: a role for DNA methylation

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Thymus and Reproduction: Sex-Linked Dysgenesia of the Gonad after Neonatal Thymectomy in Mice

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Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance

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Nonredundant roles for Stat5a/b in directly regulating Foxp3

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Aire

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A critical function for TGF-β signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells

Liu, Y., Zhang, P., Li, J., Kulkarni, A. B., Perruche, S., & Chen, W. (2008) · Nature Immunology · doi:10.1038/ni.1607 · Cited by 545 · see citing works

An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires

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High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice

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Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer

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Continuous requirement for the TCR in regulatory T cell function

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Pregnancy imprints regulatory memory that sustains anergy to fetal antigen

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DNMT1-interacting RNAs block gene-specific DNA methylation

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Regulatory T cell development in the absence of functional Foxp3

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CD4+ T cells that express high levels of CD45RB induce wasting disease when transferred into congenic severe combined immunodeficient mice. Disease development is prevented by cotransfer of purified CD4+ T cells.

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Foxp3 Exploits a Pre-Existent Enhancer Landscape for Regulatory T Cell Lineage Specification

Samstein, R. M., Arvey, A., Josefowicz, S. Z., Peng, X., Reynolds, A., Sandstrom, R., Neph, S., Sabo, P., Kim, J. M., Liao, W., et al. (2012) · Cell · doi:10.1016/j.cell.2012.06.053 · Cited by 472 · see citing works

Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells

Ouyang, W., Beckett, O. R., Ma, Q., Paik, J.-H., DePinho, R. A., & Li, M. O. (2010) · Nature Immunology · doi:10.1038/ni.1884 · Cited by 467 · see citing works

Activating Fc γ receptors contribute to the antitumor activities of immunoregulatory receptor-targeting antibodies

Bulliard, Y., Jolicoeur, R., Windman, M., Rue, S. M., Ettenberg, S. A., Knee, D. A., Wilson, N. S., Dranoff, G., & Brogdon, J. L. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20130573 · Cited by 446 · see citing works

Regulatory T cells generated early in life play a distinct role in maintaining self-tolerance

Yang, S., Fujikado, N., Kolodin, D., Benoist, C. O., & Mathis, D. J. (2015) · Science · doi:10.1126/science.aaa7017 · Cited by 444 · see citing works

The Prognostic Value of FoxP3+ Tumor-Infiltrating Lymphocytes in Cancer: A Critical Review of the Literature

deLeeuw, R., Kost, S., Kakal, J., & Nelson, B. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-3216 · Cited by 444 · see citing works

Control of the Inheritance of Regulatory T Cell Identity by a cis Element in the Foxp3 Locus

Feng, Y., Arvey, A., Chinen, T., van der Veeken, J., Gasteiger, G., & Rudensky, A. Y. (2014) · Cell · doi:10.1016/j.cell.2014.07.031 · Cited by 422 · see citing works

Developmental regulation of Foxp3 expression during ontogeny

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Novel Foxo1-dependent transcriptional programs control Treg cell function

Ouyang, W., Liao, W., Luo, C. T., Yin, N., Huse, M., Kim, M. V., Peng, M., Chan, P., Ma, Q., Mo, Y., et al. (2012) · Nature · doi:10.1038/nature11581 · Cited by 414 · see citing works

Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability

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CCR7 provides localized access to IL-2 and defines homeostatically distinct regulatory T cell subsets

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Differential impact of mammalian target of rapamycin inhibition on CD4 +CD25+Foxp3+ regulatory T cells compared with conventional CD4+ T cells

Zeiser, R., Leveson-Gower, D. B., Zambricki, E. A., Kambham, N., Beilhack, A., Loh, J., Hou, J.-Z., & Negrin, R. S. (2008) · Blood · doi:10.1182/blood-2007-06-094482 · Cited by 402 · see citing works

Nuclear Factor-κB Modulates Regulatory T Cell Development by Directly Regulating Expression of Foxp3 Transcription Factor

Long, M., Park, S., Strickland, I., Hayden, M. S., & Ghosh, S. (2009) · Immunity · doi:10.1016/j.immuni.2009.09.022 · Cited by 393 · see citing works

Development of Foxp3+ Regulatory T Cells Is Driven by the c-Rel Enhanceosome

Ruan, Q., Kameswaran, V., Tone, Y., Li, L., Liou, H., Greene, M. I., Tone, M., & Chen, Y. H. (2009) · Immunity · doi:10.1016/j.immuni.2009.10.006 · Cited by 378 · see citing works

Thymus-derived regulatory T cells contribute to tolerance to commensal microbiota

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Treg cells require the phosphatase PTEN to restrain TH1 and TFH cell responses

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Aire-Dependent Thymic Development of Tumor-Associated Regulatory T Cells

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Selection of Self-Reactive T Cells in the Thymus

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CCR7 is required for the in vivo function of CD4+ CD25+ regulatory T cells

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Continuous T Cell Receptor Signals Maintain a Functional Regulatory T Cell Pool

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Immune homeostasis enforced by co-localized effector and regulatory T cells

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Nr4a receptors are essential for thymic regulatory T cell development and immune homeostasis

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