The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
CXCR5+ CCR7– CD8 T cells are early effector memory cells that infiltrate tonsil B cell follicles
Open accessAbstract
Naive and central memory CD8 T cells use CCR7 to recirculate through T cell zones of secondary lymphoid organs where they can encounter antigen. Here we describe a subset of human CD8 T cells expressing CXCR5 which enables homing in response to CXCL13 produced within B cell follicles. CXCR5+ CD8 T cells were found in tonsil B cell follicles, and isolated cells migrated towards CXCL13 in vitro. They expressed CD27, CD28, CD45RO, CD69, and were CD7 low, and produced IFN‐γ and granzyme A but lacked perforin, a functional profile suggesting that these cells are early effector memory cells in the context of contemporary T cell differentiation models. Receptors important in the interaction with B cells, including CD70, OX40 and ICOS, were induced upon activation, and CXCR5+ CD8 T cells could to some extent support survival and IgG production in tonsil B cells. Furthermore, CXCR5+ CD8 T cells expressed CCR5 but no CCR7, suggesting a migration pattern distinct from that of follicular CD4 T cells. The finding that a subset of early effector memory CD8 T cells use CXCR5 to locate to B cell follicles indicates that MHC class I‐restricted CD8 T cells are part of the follicular T cell population.
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Cites
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
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Immune Activation and CD8+ T-Cell Differentiation towards Senescence in HIV-1 Infection
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Human CD8+ T-cell differentiation in response to viruses
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Cited by
Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy
Im, S. J., Hashimoto, M., Gerner, M. Y., Lee, J., Kissick, H. T., Burger, M. C., Shan, Q., Hale, J. S., Lee, J., Nasti, T. H., et al. (2016) · Nature · doi:10.1038/nature19330 · Cited by 2,070
Follicular CXCR5-expressing CD8+ T cells curtail chronic viral infection
He, R., Hou, S., Liu, C., Zhang, A., Bai, Q., Han, M., Yang, Y., Wei, G., Shen, T., Yang, X., et al. (2016) · Nature · doi:10.1038/nature19317 · Cited by 677
Perreau, M., Savoye, A.-L., De Crignis, E., Corpataux, J.-M., Cubas, R., Haddad, E. K., De Leval, L., Graziosi, C., & Pantaleo, G. (2013) · Journal of Experimental Medicine · doi:10.1084/jem.20121932 · Cited by 630
Fukazawa, Y., Lum, R., Okoye, A. A., Park, H., Matsuda, K., Bae, J. Y., Hagen, S. I., Shoemaker, R., Deleage, C., Lucero, C., et al. (2015) · Nature Medicine · doi:10.1038/nm.3781 · Cited by 477
CXCR5 Expressing Human Central Memory CD4 T Cells and Their Relevance for Humoral Immune Responses
Chevalier, N., Jarrossay, D., Ho, E., Avery, D. T., Ma, C. S., Yu, D., Sallusto, F., Tangye, S. G., & Mackay, C. R. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1002828 · Cited by 313
Metadata
- Authors
- Quigley, M. F., Gonzalez, V. D., Granath, A., Andersson, J., & Sandberg, J. K.
- Venue
- European Journal of Immunology
- Publisher
- Wiley
- Published
- 2007-11-29
- Volume
- 37
- Issue
- 12
- Pages
- 3352-3362
- ISSN
- 0014-2980 (ISSN-L)
- 1521-4141
- OpenAlex
- W2088543098
- Cited by
- 160
- References
- 6
- FWCI
- 1.10
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Quigley, M. F., Gonzalez, V. D., Granath, A., Andersson, J., & Sandberg, J. K. (2007). CXCR5+ CCR7– CD8 T cells are early effector memory cells that infiltrate tonsil B cell follicles. European Journal of Immunology. https://doi.org/10.1002/eji.200636746
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