The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
A serum circulating miRNA diagnostic test to identify asymptomatic high‐risk individuals with early stage lung cancer
Open accessAbstract
Lung cancer is the first cause of cancer mortality worldwide, and its early detection is currently the main available strategy to improve disease prognosis. While early diagnosis can be successfully achieved through tomography-based population screenings in high-risk individuals, simple methodologies are needed for effective cancer prevention programs. We developed a test, based on the detection of 34 microRNAs (miRNAs) from serum, that could identify patients with early stage non-small cell lung carcinomas (NSCLCs) in a population of asymptomatic high-risk individuals with 80% accuracy. The signature could assign disease probability accurately either in asymptomatic or symptomatic patients, is able to distinguish between benign and malignant lesions, and to capture the onset of the malignant disease in individual patients over time. Thus, our test displays a number of features of clinical relevance that project its utility in programs for the early detection of NSCLC.
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Cited by
MicroRNA-Based Diagnosis and Therapy
Ho, P. T. B., Clark, I. M., & Le, L. T. T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23137167 · Cited by 630
MicroRNAs in Common Human Diseases
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Circulating MicroRNAs: Biomarkers or Mediators of Cardiovascular Diseases?
Fichtlscherer, S., Zeiher, A. M., & Dimmeler, S. (2011) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.111.226696 · Cited by 339
Circulating miRNAs: Roles in cancer diagnosis, prognosis and therapy
Cheng, G. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.09.001 · Cited by 334
Telomeres and telomerase in oncogenesis (Review)
Trybek, T., Kowalik, A., Góźdź, S., & Kowalska, A. (2020) · Oncology Letters · doi:10.3892/ol.2020.11659 · Cited by 119
Metadata
- Authors
- Bianchi, F., Nicassio, F., Marzi, M., Belloni, E., Dall'Olio, V., Bernard, L., Pelosi, G., Maisonneuve, P., Veronesi, G., & Di Fiore, P. P.
- Venue
- EMBO Molecular Medicine
- Published
- 2011-07-11
- Volume
- 3
- Issue
- 8
- Pages
- 495-503
- ISSN
- 1757-4676 (ISSN-L)
- 1757-4684
- OpenAlex
- W2122080063
- Cited by
- 351
- References
- 45
- FWCI
- 10.79
- Type
- journal article
- Language
- en
- Open access
- gold
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- Bianchi, F., Nicassio, F., Marzi, M., Belloni, E., Dall'Olio, V., Bernard, L., Pelosi, G., Maisonneuve, P., Veronesi, G., & Di Fiore, P. P. (2011). A serum circulating miRNA diagnostic test to identify asymptomatic high‐risk individuals with early stage lung cancer. EMBO Molecular Medicine. https://doi.org/10.1002/emmm.201100154
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