The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
Circulating MicroRNAs: Biomarkers or Mediators of Cardiovascular Diseases?
Abstract
MicroRNAs (miRs) are small, noncoding RNAs that posttranscriptionally control gene expression by inhibiting protein translation or inducing target mRNA destabilization. Besides their intracellular function, recent studies demonstrate that miRs can be exported or released by cells and circulate with the blood in a remarkably stable form. The discovery of circulating miRs opens up intriguing possibilities to use the circulating miR patterns as biomarker for cardiovascular diseases. Cardiac injury as it occurs after acute myocardial infarction increases the circulating levels of several myocardial-derived miRs (eg, miR-1, miR-133, miR-499, miR-208), whereas patients with coronary artery disease or diabetes showed reduced levels of endothelial-enriched miRs, such as miR-126. This review article summarizes the current clinical and experimental studies addressing the role of circulating miRs as a diagnostic or prognostic biomarker in cardiovascular disease. In addition, the mechanisms by which miRs are released and their putative function as long-distance communicators are discussed.
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Cited by
Turturici, G., Tinnirello, R., Sconzo, G., & Geraci, F. (2014) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00228.2013 · Cited by 483
Microparticles: major transport vehicles for distinct microRNAs in circulation
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Methodological challenges in utilizing mi RNA s as circulating biomarkers
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HDL-transferred microRNA-223 regulates ICAM-1 expression in endothelial cells
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A Consideration of Biomarkers to be Used for Evaluation of Inflammation in Human Nutritional Studies
Calder, P. C., Ahluwalia, N., Albers, R., Bosco, N., Bourdet-Sicard, R., Haller, D., Holgate, S. T., Jönsson, L. S., Latulippe, M. E., Marcos, A., et al. (2013) · British Journal of Nutrition · doi:10.1017/s0007114512005119 · Cited by 425
Metadata
- Authors
- Fichtlscherer, S., Zeiher, A. M., & Dimmeler, S.
- Venue
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Published
- 2011-11
- Volume
- 31
- Issue
- 11
- Pages
- 2383-2390
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- OpenAlex
- W2154381563
- Cited by
- 339
- References
- 60
- FWCI
- 12.76
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
