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Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3
Open accessAbstract
Nutrient availability is the major regulator of life and reproduction, and a complex cellular signaling network has evolved to adapt organisms to fasting. These sensor pathways monitor cellular energy metabolism, especially mitochondrial ATP production and NAD + /NADH ratio, as major signals for nutritional state. We hypothesized that these signals would be modified by mitochondrial respiratory chain disease, because of inefficient NADH utilization and ATP production. Oral administration of nicotinamide riboside (NR), a vitamin B3 and NAD + precursor, was previously shown to boost NAD + levels in mice and to induce mitochondrial biogenesis. Here, we treated mitochondrial myopathy mice with NR. This vitamin effectively delayed early‐ and late‐stage disease progression, by robustly inducing mitochondrial biogenesis in skeletal muscle and brown adipose tissue, preventing mitochondrial ultrastructure abnormalities and mtDNA deletion formation. NR further stimulated mitochondrial unfolded protein response, suggesting its protective role in mitochondrial disease. These results indicate that NR and strategies boosting NAD + levels are a promising treatment strategy for mitochondrial myopathy.
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“new therapeutic strategies have emerged to restore NAD+ levels in muscle by administration of dietary NAD+ precursors such as NR or NMN46,53,54”
From Mitochondrial oxidative capacity and NAD+ biosynthesis are reduced in human sarcopenia across ethnicities (2019) · cites this paper as [54]
In the citing paper
“the conversion of these precursors to NAD+ bypasses the rate limited enzyme NAMPT”
From Mitochondrial oxidative capacity and NAD+ biosynthesis are reduced in human sarcopenia across ethnicities (2019) · cites this paper as [54]
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1 retracted
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RetractedTranscriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
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Mitochondria: In Sickness and in Health
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Self-citationAMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
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Self-citationStress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
Brunet, A., Sweeney, L. B., Sturgill, J. F., Chua, K. F., Greer, P. L., Lin, Y., Tran, H., Ross, S. E., Mostoslavsky, R., Cohen, H. Y., et al. (2004) · Science · doi:10.1126/science.1094637 · Cited by 3,239
Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
Rodgers, J. T., Lerin, C., Haas, W., Gygi, S. P., Spiegelman, B. M., & Puigserver, P. (2005) · Nature · doi:10.1038/nature03354 · Cited by 3,160
FGF-21 as a novel metabolic regulator
Kharitonenkov, A., Shiyanova, T. L., Koester, A., Ford, A. M., Micanovic, R., Galbreath, E. J., Sandusky, G. E., Hammond, L. J., Moyers, J. S., Owens, R. A., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23606 · Cited by 2,125
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Self-citationMouchiroud, L., Houtkooper, R. H., Moullan, N., Katsyuba, E., Ryu, D., Cantó, C., Mottis, A., Jo, Y.-S., Viswanathan, M., Schoonjans, K., et al. (2013) · Cell · doi:10.1016/j.cell.2013.06.016 · Cited by 1,210
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Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance
Pickles, S., Vigié, P., & Youle, R. J. (2018) · Current Biology · doi:10.1016/j.cub.2018.01.004 · Cited by 2,081
Sarcopenia: Aging-Related Loss of Muscle Mass and Function
Larsson, L., Degens, H., Li, M., Salviati, L., Lee, Y. I., Thompson, W., Kirkland, J. L., & Sandri, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00061.2017 · Cited by 1,797
Cantó, C., Menzies, K. J., & Auwerx, J. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.05.023 · Cited by 1,648
Self-citationGorman, G. S., Chinnery, P. F., DiMauro, S., Hirano, M., Koga, Y., McFarland, R., Suomalainen, A., Thorburn, D. R., Zeviani, M., & Turnbull, D. M. (2016) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2016.80 · Cited by 1,650
Self-citationNAD + in aging, metabolism, and neurodegeneration
Verdin, E. (2015) · Science · doi:10.1126/science.aac4854 · Cited by 1,319
Metadata
- Authors
- Khan, N. A., Auranen, M., Paetau, I., Pirinen, E., Euro, L., Forsström, S., Pasila, L., Velagapudi, V., Carroll, C. J., Auwerx, J., & Suomalainen, A.
- Affiliations
- University of Helsinki (FI)
- University of Eastern Finland (FI)
- Institute for Molecular Medicine Finland (FI)
- École Polytechnique Fédérale de Lausanne (CH)
- Corresponding author
- Suomalainen, Anu
- ORCID
- Venue
- EMBO Molecular Medicine
- Published
- 2014-04-07
- Volume
- 6
- Issue
- 6
- Pages
- 721-731
- ISSN
- 1757-4676 (ISSN-L)
- 1757-4684
- PMC
- PMC4203351
- OpenAlex
- W2132438126
- Cited by
- 385
- References
- 34
- Citations by year
- 2026: 15 · 2025: 25 · 2024: 19 · 2023: 32 · 2022: 29 · 2021: 36 · 2020: 45 · 2019: 37 · 2018: 39 · 2017: 31 · 2016: 30 · 2015: 34 · 2014: 12
- FWCI
- 18.17
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- EMBO Molecular Medicine (publishedVersion, other-oa)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- St George's Online Research Archive (St George's University of London) (acceptedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Työväentutkimus Vuosikirja (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Funders
- European Research Council
- Saastamoinen Foundation
- Finnish Cultural Foundation
- Finnish Diabetes Foundation
- Finnish Academy
- Jane and Aatos Erkko Foundation
- Sigrid Jusélius Foundation
- Academy of Finland, and University of Helsinki
- Ecole Polytechnique Fédérale de Lausanne
- ERC
- NIH (R01HL106511‐01A, R01AG043930)
- Velux Stiftung
- Swiss National Science Foundation
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Keywords
- nicotinamide riboside, mitochondrial myopathy, NAD+ precursors, NAD+/NADH ratio, mitochondrial biogenesis, mitochondrial unfolded protein response, mitochondrial DNA deletions, skeletal muscle, brown adipose tissue, mitochondrial ATP production, disease progression
- MeSH terms
- Forkhead Box Protein O1, Animals, Adipose Tissue, Brown, Energy Metabolism, Liver, Male, Mice, Inbred C57BL, Mitochondria, NAD, Niacinamide, Pyridinium Compounds, Vitamin B Complex, Mitochondrial Myopathies, Muscle, Skeletal, Lipid Metabolism, Mice, Forkhead Transcription Factors, Sirtuin 1, Unfolded Protein Response
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