Recent admixture between species of the fungal pathogen Histoplasma
Open accessAbstract
Abstract Hybridization between species of pathogens has the potential to speed evolution of virulence by providing the raw material for adaptation through introgression or by assembling new combinations of virulence traits. Fungal diseases are a source high morbidity, and remain difficult to treat. Yet the frequency of hybridization between fungal species has rarely been explored, and the functional role of introgressed alleles remains largely unknown. Histoplasma mississippiense and H. ohiense are sympatric throughout their range in North America and have distinct virulence strategies, making them an ideal system to examine the role introgression may play in fungal pathogens. We identified introgressed tracts in the genomes of a sample of H. mississippiense and H. ohiense isolates. We found strong evidence in each species for recent admixture, but introgressed alleles were present at low frequencies, suggesting that they were deleterious. Consistent with this, coding and regulatory sequences were strongly depleted within introgressed regions, whereas intergenic regions were enriched, indicating that functional introgressed alleles were frequently deleterious in their new genomic context. Surprisingly, we found only two isolates with substantial admixture: the H. mississippiense and H. ohiense genomic reference strains, WU24 and G217B, respectively. Our results show that recent admixture has occurred, that it is frequently deleterious and that conclusions based on studies of the H. mississippiense and H. ohiense type strains should be revisited with more representative samples from the genus.
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Histoplasma capsulatum sensu stricto is endemic to Panama and the northern portion of South America.
“Histoplasma capsulatum sensu stricto is endemic to Panama and the northern portion of South America [161]”
From Race and ethnicity: Risk factors for fungal infections? (2023) · cites this paper as [161]
Histoplasma suramericanum is distributed widely across South America.
“while Histoplasma suramericanum is distributed widely across South America.”
From Race and ethnicity: Risk factors for fungal infections? (2023) · cites this paper as [161]
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Race and ethnicity: Risk factors for fungal infections?
Jenks, J. D., Aneke, C. I., Al-Obaidi, M. M., Egger, M., Garcia, L., Gaines, T., Hoenigl, M., & Thompson, G. R. (2023) · PLOS Pathogens · doi:10.1371/journal.ppat.1011025 · Cited by 55 · see citing works
- Authors
- Maxwell, C. S., Sepulveda, V. E., Turissini, D. A., Goldman, W. E., & Matute, D. R.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Department of Microbiology and Immunology, School of Medicine University of North Carolina Chapel Hill North Carolina 27599
- Venue
- Evolution Letters
- Publisher
- Oxford University Press (OUP)
- Published
- 2018-06-01
- Volume
- 2
- Issue
- 3
- Pages
- 210-220
- ISSN
- 2056-3744 (ISSN-L)
- PMC
- PMC6121842
- OpenAlex
- W2808719064
- Cited by
- 35
- References
- 63
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 6 · 2023: 3 · 2022: 1 · 2021: 8 · 2020: 4 · 2019: 9 · 2018: 1
- FWCI
- 4.29
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Evolution Letters (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Institute of General Medical Sciences (R01GM121750, T32-AI052080)
- Topics
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Keywords
- interspecific hybridization, introgression, admixture, fungal pathogens, virulence evolution, histoplasmosis, intergenic regions
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