Genome Sequences Reveal Cryptic Speciation in the Human Pathogen Histoplasma capsulatum
Open accessAbstract
Histoplasma capsulatum is a pathogenic fungus that causes life-threatening lung infections. About 500,000 people are exposed to H. capsulatum each year in the United States, and over 60% of the U.S. population has been exposed to the fungus at some point in their life. We performed genome-wide population genetics and phylogenetic analyses with 30 Histoplasma isolates representing four recognized areas where histoplasmosis is endemic and show that the Histoplasma genus is composed of at least four species that are genetically isolated and rarely interbreed. Therefore, we propose a taxonomic rearrangement of the genus. IMPORTANCE The evolutionary processes that give rise to new pathogen lineages are critical to our understanding of how they adapt to new environments and how frequently they exchange genes with each other. The fungal pathogen Histoplasma capsulatum provides opportunities to precisely test hypotheses about the origin of new genetic variation. We find that H. capsulatum is composed of at least four different cryptic species that differ genetically and also in virulence. These results have implications for the epidemiology of histoplasmosis because not all Histoplasma species are equivalent in their geographic range and ability to cause disease.
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Histoplasma mississippiense is distributed in the Mississippi River Valley and Histoplasma ohiense in the Ohio River Valley, both in the US.
“Histoplasma mississippiense is distributed in the Mississippi River Valley and Histoplasma ohiense in the Ohio River Valley, both in the US [162].”
From Race and ethnicity: Risk factors for fungal infections? (2023) · cites this paper as [162]
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Self-citationName Changes for Fungi of Medical Importance, 2016–2017
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Histoplasmosis in Children; HIV/AIDS Not a Major Driver
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Genetic Diversity of Human Fungal Pathogens
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Recyclable CRISPR/Cas9-mediated gene disruption and deletions in Histoplasma
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Evolutionary origin, population diversity, and diagnostics for a cryptic hybrid pathogenPreprint
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Genomic epidemiology of Histoplasma in Africa
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Genotypic diversity, virulence, and molecular genetic tools in Histoplasma
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- Authors
- Sepúlveda, V. E., Márquez, R., Turissini, D. A., Goldman, W. E., & Matute, D. R.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- University of Chicago (US)
- Corresponding author
- Matute, Daniel R.
- Venue
- mBio
- Publisher
- American Society for Microbiology
- Published
- 2017-12-29
- Volume
- 8
- Issue
- 6
- ISSN
- 2150-7511 (ISSN-L)
- 2161-2129
- PMC
- PMC5717386
- OpenAlex
- W2774779777
- Cited by
- 175
- References
- 112
- Citations by year
- 2026: 11 · 2025: 21 · 2024: 25 · 2023: 26 · 2022: 18 · 2021: 23 · 2020: 21 · 2019: 23 · 2018: 7
- FWCI
- 10.92
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- mBio (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- UNC Libraries
- Topics
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Plant Pathogens and Fungal Diseases
- Keywords
- Histoplasma capsulatum, cryptic speciation, histoplasmosis, population genetics, phylogenetic analysis, virulence, genetic isolation, endemic areas, fungal evolution
- MeSH terms
- Histoplasma, Histoplasmosis, Humans, Phylogeny, Genetic Variation, Genome, Fungal, Genetic Speciation
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