The DOI matches its Crossref record; 131 of the 131 references it cites were found in a registry or an index.
Nanozyme for tumor therapy: Surface modification matters
Open accessAbstract
As the next generation of artificial enzymes, nanozymes have shown unique properties compared to its natural counterparts, such as stability in harsh environment, low cost, and ease of production and modification, paving the way for its biomedical applications. Among them, tumor catalytic therapy mediated by the generation of reactive oxygen species (ROS) has made great progress mainly from the peroxidase‐like activity of nanozymes. Fe 3 O 4 nanozymes, the earliest type of nanomaterial discovered to possess peroxidase‐like activity, has consequently received wide attention for tumor therapy due to its ROS generation ability and tumor cell killing ability. However, inconsistent results of cytotoxicity were observed between different reports, and some even showed the scavenging of ROS in some cases. By collectively studying these inconsistent outcomes, we raise the question whether surface modification of Fe 3 O 4 nanozymes, either through affecting peroxidase activity or by affecting the biodistribution and intracellular fate, play an important role in its therapeutic effects. This review will go over the fundamental catalytic mechanisms of Fe 3 O 4 nanozymes and recent advances in tumor catalytic therapy, and discuss the importance of surface modification. Employing Fe 3 O 4 nanozymes as an example, we hope to provide an outlook on the improvement of nanozyme‐based antitumor activity.
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Cites
Intrinsic peroxidase-like activity of ferromagnetic nanoparticles
Gao, L., Zhuang, J., Nie, L., Zhang, J., Zhang, Y., Gu, N., Wang, T., Feng, J., Yang, D., Perrett, S., et al. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.260 · Cited by 7,483
Self-citationNanomaterials with enzyme-like characteristics (nanozymes): next-generation artificial enzymes (II)
Wu, J., Wang, X., Wang, Q., Lou, Z., Li, S., Zhu, Y., Qin, L., & Wei, H. (2019) · Chemical Society Reviews · doi:10.1039/c8cs00457a · Cited by 4,108
Nanomaterials with enzyme-like characteristics (nanozymes): next-generation artificial enzymes
Wei, H., & Wang, E. (2013) · Chemical Society Reviews · doi:10.1039/c3cs35486e · Cited by 3,779
Fundamentals of Cancer Metabolism
DeBerardinis, R. J., & Chandel, N. S. (2016) · Science Advances · doi:10.1126/sciadv.1600200 · Cited by 3,013
The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles
Fröhlich, E. (2012) · International Journal of Nanomedicine · doi:10.2147/ijn.s36111 · Cited by 2,484
Reddy, L. H., Arias, J. L., Nicolas, J., & Couvreur, P. (2012) · Chemical Reviews · doi:10.1021/cr300068p · Cited by 2,010
Chemodynamic Therapy: Tumour Microenvironment‐Mediated Fenton and Fenton‐like Reactions
Tang, Z., Liu, Y., He, M., & Bu, W. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201805664 · Cited by 1,951
Nanoparticle Size and Surface Chemistry Determine Serum Protein Adsorption and Macrophage Uptake
Walkey, C. D., Olsen, J. B., Guo, H., Emili, A., & Chan, W. C. W. (2012) · Journal of the American Chemical Society · doi:10.1021/ja2084338 · Cited by 1,926
Zanganeh, S., Hutter, G., Spitler, R., Lenkov, O., Mahmoudi, M., Shaw, A., Pajarinen, J. S., Nejadnik, H., Goodman, S., Moseley, M., et al. (2016) · Nature Nanotechnology · doi:10.1038/nnano.2016.168 · Cited by 1,647
Wei, H., & Wang, E. (2008) · Analytical Chemistry · doi:10.1021/ac702203f · Cited by 1,412
Cited by
Deciphering the catalytic mechanism of superoxide dismutase activity of carbon dot nanozyme
Gao, W., He, J., Chen, L., Meng, X., Ma, Y., Cheng, L., Tu, K., Gao, X., Liu, C., Zhang, M., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-35828-2 · Cited by 622
Self-citationZhang, S., Li, Y., Sun, S., Liu, L., Mu, X., Liu, S., Jiao, M., Chen, X., Chen, K., Ma, H., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-32411-z · Cited by 280
Zhao, Y., Wang, S., Ding, Y., Zhang, Z., Huang, T., Zhang, Y., Wan, X., Wang, Z. L., & Li, L. (2022) · ACS Nano · doi:10.1021/acsnano.2c01968 · Cited by 235
Dong, C., Dai, X., Wang, X., Lu, Q., Chen, L., Song, X., Ding, L., Huang, H., Feng, W., Chen, Y., et al. (2022) · Advanced Materials · doi:10.1002/adma.202205680 · Cited by 130
Hu, B., Xiao, X., Chen, P., Qian, J., Yuan, G., Ye, Y., Zeng, L., Zhong, S., Wang, X., Qin, X., et al. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121811 · Cited by 73
Metadata
- Authors
- Tang, G., He, J., Liu, J., Yan, X., & Fan, K.
- Venue
- Exploration
- Publisher
- Wiley
- Published
- 2021-08
- Volume
- 1
- Issue
- 1
- Pages
- 75-89
- ISSN
- 2766-2098 (ISSN-L)
- OpenAlex
- W3197159314
- Cited by
- 441
- References
- 131
- FWCI
- 23.29
- Type
- journal article
- Language
- en
- Open access
- gold
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