In Vitro Study of the Effect of Quinoa and Quinoa Polysaccharides on Human Gut Microbiota
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Abstract It has been shown that whole grains and dietary fiber are important for their fermentation characteristics in the large intestine, drawing more and more attention to quinoa and quinoa polysaccharides. In this study, we evaluated the prebiotic effect of quinoa seeds and quinoa polysaccharides after human simulated digestion. The modulatory effect of the quinoa and quinoa polysaccharides (QPs) on the gut microbiota was evaluated by the in vitro fermentation using human fecal microbiota. The yield of polysaccharides extraction was 15.45%. The digestibility of the cooked and uncooked quinoa after simulation of human digestion was 69.04% and 64.09%, respectively. The effect on the microbiota composition and their metabolic products was determined by the assessment of pH, short‐chain fatty acids (SCFAs), and changes in the bacterial population. After 24 hr anaerobic incubation, the total SCFAs of cooked, uncooked quinoa, and quinoa polysaccharides were 82.99, 77.11, and 82.73 mM, respectively with a pH decrease. At the phylum, genus, and class level, it has been found that the quinoa substrates enhance the growth of certain beneficial bacteria such as Prevotella and Bacteroides . Quinoa polysaccharides can be considered prebiotic due to their ability to increase Bifidobacterium and Collinsella . Principal component analysis (PCA) showed that there was a distinct modulating effect on the fecal microbiota which represents different distribution. Our research suggests that quinoa and quinoa polysaccharides have a prebiotic potential due to their association with the positive shifts in microbiota composition and short‐chain fatty acids production, which highlights the importance of further studies around this topic.
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Quinoa's polysaccharides enhanced the synthesis of short-chain fatty acids and the composition of the microbiota; they might function as prebiotics.
“Quinoa’s polysaccharides enhanced the synthesis of short-chain fatty acids and the composition of the microbiota. They might function as prebiotics [201].”
From Ecdysterone and Turkesterone—Compounds with Prominent Potential in Sport and Healthy Nutrition (2024) · cites this paper as [201]
In vitro studies reported quinoa's effects on gut microbiota and cancer cells, antioxidant and antidiabetic properties, platelet activity, and modulating collagenase activity.
“The in vitro studies presented in Table 7 reported quinoa’s effects on gut microbiota and cancer cells, antioxidant and antidiabetic properties, platelet activity, and modulating collagenase activity [201,202,203,204,205,206,207].”
From Ecdysterone and Turkesterone—Compounds with Prominent Potential in Sport and Healthy Nutrition (2024) · cites this paper as [201]
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Ecdysterone and Turkesterone—Compounds with Prominent Potential in Sport and Healthy Nutrition
Todorova, V., Ivanova, S., Chakarov, D., Kraev, K., & Ivanov, K. (2024) · Nutrients · doi:10.3390/nu16091382 · Cited by 31 · see citing works
“…and its polysaccharides improved microbiota composition and short-chain fatty acid synthesis. properties, including anti-inflammatory They are potential prebiotics. anti-inflammatory cardio-beneficial effects (Figure 4 [201] rich in The effect of C. quinoa leaves phenolic compounds on cancer cells.”
BackgroundInfluential
- Authors
- Zeyneb, H., Pei, H., Cao, X., Wang, Y., Win, Y., & Gong, L.
- Affiliations
- Beijing Technology and Business University (CN)
- Corresponding author
- Pei, Hairun
- Cao, Xueli
- Venue
- Food Science & Nutrition
- Publisher
- Wiley
- Published
- 2021-08-21
- Volume
- 9
- Issue
- 10
- Pages
- 5735-5745
- ISSN
- 2048-7177 (ISSN-L)
- PMC
- PMC8498072
- OpenAlex
- W3194587683
- Cited by
- 62
- References
- 53
- Citations by year
- 2026: 8 · 2025: 18 · 2024: 16 · 2023: 10 · 2022: 9 · 2021: 1
- FWCI
- 5.74
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Food Science & Nutrition (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (21773014)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Seed and Plant Biochemistry
- Keywords
- quinoa, prebiotic activity, gut microbiota, human fecal microbiota, short-chain fatty acids, dietary fiber, Bifidobacterium, Collinsella, Prevotella, Bacteroides
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