Cited by 355Medicinal Plant ResearchPhytochemistry and Biological ActivitiesBioactive natural compounds

Phytobioactive compounds as therapeutic agents for human diseases: A review

Open access
Riaz, Muhammad, Khalid, Ramsha, Afzal, Muhammad, Anjum, Fozia, Fatima, Hina, Zia, Saadiya, Rasool, Ghulam, Egbuna, Chukwuebuka +3 more·2023·Food Science & Nutrition

Abstract

Phytobioactive compounds are plant secondary metabolites and bioactive compounds abundantly present in medicinal plants and have remarkable therapeutic potential. Oxidative stress and antibiotic resistance are major causes of present-day ailments such as diabetes, atherosclerosis, cardiovascular disorders, cancer, and inflammation. The data for this review were collected from Google Scholar, PubMed, Directory of Open Access Journals (DOAJ), and Science Direct by using keywords: "Medicinal plants, Phytobioactive compounds, Polyphenols, Alkaloids, Carotenoids etc." Several studies have reported the pharmacological and therapeutic potential of the phytobioactives. Polyphenols, alkaloids, terpenes, and polysaccharides isolated from medicinal plants showed remarkable antioxidant, anticancer, cytotoxic, anti-inflammatory, cardioprotective, hepatoprotective, immunomodulatory, neuroprotective, and antidiabetic activities. This literature review was planned to provide comprehensive insight into the biopharmacological and therapeutic potential of phytobioactive compounds. The techniques used for the extraction and isolation of phytobioactive compounds, and bioassays required for their biological activities such as antioxidant, antimicrobial, anti-inflammatory, and cytotoxic activities, have been discussed. Characterization techniques for the structural elucidation of phytobioactive compounds such as HPLC, TLC, FTIR, GC-MS/MS, and NMR have also been discussed. This review concludes that phytobioactive compounds may be used as potential alternative to synthetic compounds as therapeutic agents for the treatment of various diseases.

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  • Phytochemicals like alkaloids, flavonoids, and terpenoids have demonstrated potential in addressing neurodegenerative diseases including Alzheimer's disease by combating oxidative stress, minimizing inflammation, and protecting neurons.

    “Phytochemicals like alkaloids, flavonoids, and terpenoids have demonstrated potential in addressing neurodegenerative diseases (NNDs), including AD, by combating oxidative stress, minimizing inflammation, and protecting neurons [13,14].”

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Authors
Riaz, M., Khalid, R., Afzal, M., Anjum, F., Fatima, H., Zia, S., Rasool, G., Egbuna, C., Mtewa, A. G., Uche, C. Z., & Aslam, M. A.
Affiliations
  • University of Sargodha (PK)
  • University of Agriculture Faisalabad (PK)
  • Hill Fruit Research Station Sunny Bank Murree Pakistan
  • Government College University, Faisalabad (PK)
  • University of Central Punjab (PK)
  • University of Port Harcourt (NG)
  • Malawi University of Science and Technology (MW)
  • University of Nigeria (NG)
Corresponding author
  • Riaz, Muhammad
  • Anjum, Fozia
Venue
Food Science & Nutrition
Publisher
Wiley
Published
2023-04-17
Volume
11
Issue
6
Pages
2500-2529
ISSN
2048-7177 (ISSN-L)
OpenAlex
W4366287784
Cited by
355
References
220
Citations by year
2026: 153 · 2025: 118 · 2024: 73 · 2023: 10
FWCI
8.44
Type
journal article
Language
en
Open access
Locations
  • Food Science & Nutrition (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Informationszentrum Lebenswissenschaften (ZB MED) (submittedVersion, cc-by)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioactive natural compounds
Keywords
plant secondary metabolites, medicinal plants, polyphenols, alkaloids, terpenes, polysaccharides, antioxidant activity, anticancer activity, anti-inflammatory activity, cardioprotective activity, hepatoprotection, neuroprotective activity, antidiabetic activity, antimicrobial activity, cytotoxicity, oxidative stress, antibiotic resistance, structure elucidation, bioassay

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