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Cited by 351Genetic Associations and EpidemiologyNeurotransmitter Receptor Influence on BehaviorPersonality Traits and Psychology

The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.

Genetic covariation between neuroticism and the symptoms of anxiety and depression

Jardine, R., Martin, N. G., Henderson, A. S., Rao, D. C.·1984·Genetic Epidemiology
DOI 10.1002/gepi.1370010202
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Abstract

A genetic analysis of the trait of neuroticism and symptoms of anxiety and depression in 3,810 pairs of adult MZ and DZ twins is reported. Differences between people in these measures can be explained simply by differences in their genes and in their individual environmental experiences. There is no evidence that environmental experiences that are shared by cotwins, such as common family environment or social influences, are important. There are differences between the sexes in gene action affecting neuroticism, and genetic effects become more pronounced with age in females. The lack of evidence for dominance variance affecting neuroticism contrasts well with the detection of considerable genetical nonadditivity for extraversion in the same sample and reinforces the view that these two traits are not only statistically, but also genetically, quite independent. An analysis of the causes of covariation between anxiety, depression, and neuroticism shows that additive gene effects are more important causes of covariation than environmental factors. Genetic variation in symptoms of anxiety and depression is largely dependent on the same factors as effect the neuroticism trait. However, there is also evidence for genetic variation specific to depression.

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Citations

Cites

Research works printed but not linked: 11

  1. Clifford CA, 1981, Twin Research 3: Intelligence, Personality, and Development, 163
  2. Eaves LJ, 1981, Genetical theory and personality differences, 129
  3. Eysenck HJ, 1975, Personality Questionnaire (Junior and Adult) Hodder and Stoughton Educational.
  4. Fulker DW, 1978, Twin Research: Psychology and Methodology, 217
  5. Lord FM, 1968, Statistical Theories of Mental Test Scores
  6. Martin NG, 1981, Twin Research 3: Epidemiological and Clinical Studies, 89
  7. Schepank H, 1973, Erb‐und unweltfaktorean bein neurosen. Ergebnisse der zwillingsforschung und anderer methoden, Nervenarzt, 44, 449
  8. Schepank H, 1971, Erb‐und unwelteindflusse bei 50 neurotischen zwillingspaaren, Z Psychother Med Psychol, 21, 41
  9. Shields J, 1976, Research in Neurosis
  10. Slater E, 1969, Studies of Anxiety, 62
  11. Snedecor GW, 1980, Statistical Methods

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Metadata

Authors
Jardine, R., Martin, N. G., Henderson, A. S., & Rao, D. C.
Affiliations
Australian National University (AU)
Corresponding author
Martin, N. G.
ORCID
Venue
Genetic Epidemiology
Publisher
Wiley
Published
1984-01
Volume
1
Issue
2
Pages
89-107
ISSN
  • 0741-0395 (ISSN-L)
  • 1098-2272
DOI
10.1002/gepi.1370010202
OpenAlex
W2118929411
Cited by
351
References
54
Citations by year
2026: 2 · 2025: 4 · 2024: 3 · 2023: 1 · 2022: 4 · 2021: 6 · 2020: 3 · 2019: 8 · 2018: 7 · 2017: 8 · 2016: 7 · 2015: 6 · 2014: 8 · 2013: 7 · 2012: 8
FWCI
4.25
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 7824 d)
Locations
  • Genetic Epidemiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Health and Medical Research Council
  • National Medical Research Council
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Social Sciences › Psychology › Clinical Psychology › Personality Traits and Psychology
Keywords
neuroticism, anxiety symptoms, depressive symptoms, genetic covariance, twin studies, monozygotic twins, dizygotic twins, heritability, sex differences, age differences, dominance variance, non-additive genetic effects, extraversion, personality traits
MeSH terms
Adolescent, Adult, Anxiety, Biometry, Depression, Diseases in Twins, Environment, Female, Humans, Male, Models, Genetic, Neurotic Disorders, Surveys and Questionnaires, Sex Factors, Twins, Dizygotic, Twins, Monozygotic, Genetic Variation

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