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Untitled work

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Successful cognitive aging is associated with thicker anterior cingulate cortex and lower tau deposition compared to typical aging

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Sex differences in dementia: on the potentially mediating effects of educational attainment and experiences of psychological distress

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A Multi-Cohort Study of ApoE ɛ4 and Amyloid-β Effects on the Hippocampus in Alzheimer’s Disease

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Apolipoprotein E epsilon 4 ( APOE ‐ε4) genotype is associated with decreased 6‐month verbal memory performance after mild traumatic brain injury

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Sorting Out the Role of the Sortilin-Related Receptor 1 in Alzheimer’s Disease

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APOE ɛ4 Gene Dose and Sex Effects on Alzheimer’s Disease MRI Biomarkers in Older Adults with Mild Cognitive Impairment

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Apolipoprotein E Genotype e2: Neuroprotection and Its Limits

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Spatial patterns of tau deposition are associated with amyloid, ApoE, sex, and cognitive decline in older adults

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Myelin repair in Alzheimer’s disease: a review of biological pathways and potential therapeutics

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Race-Related Association between APOE Genotype and Alzheimer’s Disease: A Systematic Review and Meta-Analysis

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APOE ε4 Modifies Effect of Residential Greenness on Cognitive Function among Older Adults: A Longitudinal Analysis in China

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APOE2 mitigates disease-related phenotypes in an isogenic hiPSC-based model of Alzheimer’s disease

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The ApoE ε4 Isoform: Can the Risk of Diseases be Reduced by Environmental Factors?

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Protective role of the apolipoprotein E2 allele in age-related disease traits and survival: evidence from the Long Life Family Study

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Impact of Apolipoprotein E gene polymorphism during normal and pathological conditions of the brain across the lifespan

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Intrinsic functional connectivity alterations in cognitively intact elderly APOE ε4 carriers measured by eigenvector centrality mapping are related to cognition and CSF biomarkers: a preliminary study

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APOE modifies the interaction of entorhinal cerebral blood flow and cortical thickness on memory function in cognitively normal older adults

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Genetic and regulatory architecture of Alzheimer's disease in the APOE region

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APOE Polymorphism Affects Brain Default Mode Network in Healthy Young Adults

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Effect of apolipoprotein genotype and educational attainment on cognitive function in autosomal dominant Alzheimer’s disease

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Sex differences in risk of Alzheimer's disease in adults with Down syndrome

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Affect of APOE on information processing speed in non-demented elderly population: a preliminary structural MRI study

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Dissociable effects of the apolipoprotein-E (APOE) gene on short- and long-term memories

Zokaei, N., Čepukaitytė, G., Alexander Board, Mackay, C. E., Masud Husain, B., & Nobre, A. C. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.09.017 · Cited by 28 · see citing works

APOE region molecular signatures of Alzheimer's disease across races/ethnicities

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Alzheimer’s disease genetic risk and cognitive reserve in relationship to long-term cognitive trajectories among cognitively normal individuals

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Genetic Alzheimer’s Disease Risk Affects the Neural Mechanisms of Pattern Separation in Hippocampal Subfields

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APOE E2/E2 Is Associated with Slower Rate of Cognitive Decline with Age

Sweigart, B., Andersen, S. L., Gurinovich, A., Cosentino, S., Schupf, N., Perls, T. T., & Paola Sebastiani, B. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-201205 · Cited by 27 · see citing works

The Roles of Apolipoprotein E, Lipids, and Glucose in the Pathogenesis of Alzheimer’s Disease

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Protective Variants in Alzheimer’s Disease

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Does the imbalance in the apolipoprotein E isoforms underlie the pathophysiological process of sporadic Alzheimer's disease?

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APOE4 is a Risk Factor and Potential Therapeutic Target for Alzheimer's Disease

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Stimulating myelin restoration with BDNF: a promising therapeutic approach for Alzheimer's disease

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Apolipoprotein E genotypes and plasma levels in mild cognitive impairment conversion to Alzheimer's disease: A follow‐up study

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Associations of Apolipoprotein E ε4 Genotype and Ball Heading With Verbal Memory in Amateur Soccer Players

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Associations Between APOE Variants, Tau and α-Synuclein

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APOE – a genetic marker of comorbidity in subjects with morbid obesity

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Prevalence and associated factors of chemotherapy‐related cognitive impairment in older breast cancer survivors

Zhou, X., Zhang, X., Zhong, T., Zhou, M., Gao, L., & Chen, L. (2023) · Journal of Advanced Nursing · doi:10.1111/jan.15842 · Cited by 24 · see citing works

Effect of apolipoprotein E polymorphism on cognition and brain in the Cambridge Centre for Ageing and Neuroscience cohort

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The protective gene dose effect of the APOE ε2 allele on gray matter volume in cognitively unimpaired individuals

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Sex differences in associations between APOE ε2 and longitudinal cognitive decline

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APOE signaling in neurodegenerative diseases: an integrative approach targeting APOE coding and noncoding variants for disease intervention

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How Research on Human Progeroid and Antigeroid Syndromes Can Contribute to the Longevity Dividend InitiativePreprint

Hisama, F. M., Oshima, J., & Martin, G. M. (2016) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a025882 · Cited by 21 · see citing works

Does apolipoprotein E genotype influence cognition in middle-aged individuals?

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APOE ε4 associated with preserved executive function performance and maintenance of temporal and cingulate brain volumes in younger adults

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APOE ε4 Genotype and Cognitive Reserve Effects on the Cognitive Functioning of Healthy Elders

López, M. E., Turrero, A., Delgado‐Losada, M. L., Rodríguez‐Rojo, I. C., Arrazola, J., Barabash, A., Maestú, F., & Fernández, A. (2017) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000481852 · Cited by 21 · see citing works

Young people's moral attitudes and motivations towards direct-to-consumer genetic testing for inherited risk of Alzheimer disease

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Altered effective connectivity anchored in the posterior cingulate cortex and the medial prefrontal cortex in cognitively intact elderly APOE ε4 carriers: a preliminary study

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The Potential of Pathological Protein Fragmentation in Blood-Based Biomarker Development for Dementia – With Emphasis on Alzheimer’s Disease

Inekci, D., Jonesco, D. S., Kennard, S., Karsdal, M. A., & Henriksen, K. (2015) · Frontiers in Neurology · doi:10.3389/fneur.2015.00090 · Cited by 19 · see citing works

Differential Effect of APOE Alleles on Brain Glucose Metabolism in Targeted Replacement Mice: An [¹⁸F]FDG-μPET Study

Venzi, M., Tóth, M., Häggkvist, J., Bogstedt, A., Rachalski, A., Mattsson, A., Frumento, P., & Farde, L. (2017) · Journal of Alzheimer's Disease Reports · doi:10.3233/adr-170006 · Cited by 18 · see citing works

Investigating the synergistic effects of hormone replacement therapy, apolipoprotein E and age on brain health in the UK Biobank

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Humanin variant P3S is associated with longevity in APOE4 carriers and resists APOE4‐induced brain pathology

Miller, B., Kim, S., Cao, K., Mehta, H. H., Thumaty, N., Kumagai, H., Iida, T., McGill, C. J., Pike, C. J., Nurmakova, K., et al. (2024) · Aging Cell · doi:10.1111/acel.14153 · Cited by 18 · see citing works

Possible positive effect of the APOE ε2 allele on cognition in early to mid-adult life

Sinclair, L. I., Pleydell-Pearce, C. W., & Day, I. N. M. (2017) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2017.10.008 · Cited by 18 · see citing works

Interaction of APOE, cerebral blood flow, and cortical thickness in the entorhinal cortex predicts memory decline

Hays, C. C., Zlatar, Z. Z., Meloy, M. J., Bondi, M. W., Gilbert, P. E., Liu, T., Helm, J. L., & Wierenga, C. E. (2020) · Brain Imaging and Behavior · doi:10.1007/s11682-019-00245-x · Cited by 18 · see citing works

Default mode network connectivity and cognition in the aging brain: the effects of age, sex, and APOE genotype.

Shafer, A. T., Beason-Held, L., An, Y., Williams, O. A., Huo, Y., Landman, B. A., Caffo, B. S., & Resnick, S. M. (2021) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2021.03.013 · Cited by 16 · see citing works

Risk-reducing Apolipoprotein E and Clusterin genotypes protect against the consequences of poor vascular health on executive function performance and change in nondemented older adults

McFall, G. P., Sapkota, S., McDermott, K. L., & Dixon, R. A. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.02.032 · Cited by 17 · see citing works

Human Apolipoprotein E Genotype Differentially Affects Olfactory Behavior and Sensory Physiology in Mice

East, B. S., Fleming, G., Peng, K., Olofsson, J., Levy, E., Mathews, P. M., & Wilson, D. A. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.04.009 · Cited by 17 · see citing works

Exploring the effect of the apolipoprotein E (APOE) gene on executive function, working memory, and processing speed during the early recovery period following traumatic brain injury

Padgett, C. R., Summers, M. J., Vickers, J. C., McCormack, G. H., & Skilbeck, C. E. (2016) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803395.2015.1137557 · Cited by 17 · see citing works

Arabidopsis thaliana extracts optimized for polyphenols production as potential therapeutics for the APOE-modulated neuroinflammation characteristic of Alzheimer’s disease in vitro

Ghura, S., Tai, L. M., Zhao, M., Collins, N., Che, C., Warpeha, K. M., & LaDu, M. J. (2016) · Scientific Reports · doi:10.1038/srep29364 · Cited by 17 · see citing works

The Effect of Gender and APOE ɛ4 Status on Brain Amyloid-β Deposition in Different Age Groups of Mild Cognitively Impaired Individuals: A PET-CT Study

Wang, J., Wang, M., Ren, S., Huang, L., He, K., Li, J., Hua, F., Guan, Y., Guo, Q., Huang, Q., et al. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-221166 · Cited by 15 · see citing works

Decreased Inter-Hemispheric Functional Connectivity in Cognitively Intact Elderly APOE ɛ 4 Carriers: A Preliminary Study

Luo, X., Qiu, T., Xu, X., Huang, P., Gu, Q., Shen, Z., Yu, X., Jia, Y., Guan, X., Song, R., et al. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-150989 · Cited by 15 · see citing works

Apolipoprotein E Genotype e2: Neuroprotection and Its Limits

Kim, H., Devanand, D. P., Carlson, S., & Goldberg, T. E. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.919712 · Cited by 36 · see citing works

NEUROPROTECTIVE EFFECT OF APOE2: EVIDENCE AND IMPLICATION FOR COGNITIVE AGING

Paola Sebastiani, B., & Raghavachari, N. (2019) · Innovation in Aging · doi:10.1093/geroni/igz038.2312 · Cited by 1 · see citing works

APOE2: protective mechanism and therapeutic implications for Alzheimer’s disease

Li, Z., Shue, F., Zhao, N., Shinohara, M., & Bu, G. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-00413-4 · Cited by 306 · see citing works

APOE2 promotes longevity independent of Alzheimer’s diseasePreprint

Shinohara, M., Kanekiyo, T., Tachibana, M., Kurti, A., Shinohara, M., Fu, Y., Zhao, J., Han, X., Sullivan, P. M., Rebeck, W. G., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.08.31.255141

APOE2 is associated with longevity independent of Alzheimer’s disease

Shinohara, M., Kanekiyo, T., Tachibana, M., Kurti, A., Shinohara, M., Fu, Y., Zhao, J., Han, X., Sullivan, P. M., Rebeck, G. W., et al. (2020) · eLife · doi:10.7554/elife.62199 · Cited by 82 · see citing works