The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Type‐2 cells as link between glial and neuronal lineage in adult hippocampal neurogenesis
Abstract
In the course of adult hippocampal neurogenesis, new cells go through a series of stages associated with proliferative activity. The most highly proliferative cell type is an intermediate precursor cell, called type‐2 cell. We here report that on the level of type‐2 cells a transition takes place between features associated with the glial and the neuronal lineage. We show that stem‐cell marker Sox2 and radial glia marker BLBP are expressed in type‐2 cells but label only a small percentage of the proliferating cells. By and large, precursor cell marker Sox2 was found to be widely expressed in hippocampal astrocytes. Between 3 h and 1 week after a single injection of permanent S‐phase marker bromodeoxyuridine (BrdU), the number of BrdU‐labeled BLBP‐positive cells did not change, consistent with the idea that both markers here are associated with the maintained precursor cell pool. Using reporter gene mice expressing the green fluorescent protein (GFP) under the promoter for nestin we found an overlap of GFP with markers of the neuronal lineage, doublecortin (DCX) and transcription factor NeuroD1 in type‐2 cells, whereas in glial fibrillary acidic protein (GFAP)‐GFP mice expression of GFP and NeuroD1 or DCX was mutually exclusive. Electrophysiologically, the group of type‐2 cells fell into two subgroups: one with astrocytic properties and another with an early “complex” phenotype of neural progenitor cells. Our data further support the existence of proliferative precursor cells that mark the transition between glia‐like states and neuronal differentiation. © 2006 Wiley‐Liss, Inc.
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CNS stem cells express a new class of intermediate filament protein
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Neurons derived from radial glial cells establish radial units in neocortex
Noctor, S. C., Flint, A. C., Weissman, T. A., Dammerman, R. S., & Kriegstein, A. R. (2001) · Nature · doi:10.1038/35055553 · Cited by 2,016
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Astrocytes give rise to new neurons in the adult mammalian hippocampus
Seri, B., Garcı́a-Verdugo, J. M., McEwen, B. S., & Alvarez-Buylla, A. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-18-07153.2001 · Cited by 1,495
Milestones of neuronal development in the adult hippocampus
Kempermann, G., Jessberger, S., Steiner, B., & Kronenberg, G. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.05.013 · Cited by 1,423
Self-citationAlvarez-Buylla, A., & Lim, D. A. (2004) · Neuron · doi:10.1016/s0896-6273(04)00111-4 · Cited by 1,318
GABA regulates synaptic integration of newly generated neurons in the adult brain
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Glial cells generate neurons: the role of the transcription factor Pax6
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The Glial Nature of Embryonic and Adult Neural Stem Cells
Kriegstein, A., & Alvarez-Buylla, A. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135600 · Cited by 2,475
Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults
Sorrells, S. F., Paredes, M. F., Cebrian-Silla, A., Sandoval, K., Qi, D., Kelley, K. W., James, D., Mayer, S., Chang, J., Auguste, K. I., et al. (2018) · Nature · doi:10.1038/nature25975 · Cited by 1,422
Adult Neurogenesis in the Hippocampus: From Stem Cells to Behavior
Gonçalves, J. T., Schafer, S. T., & Gage, F. H. (2016) · Cell · doi:10.1016/j.cell.2016.10.021 · Cited by 1,122
Neurogenesis in the adult hippocampus
Kempermann, G., Song, H., & Gage, F. H. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a018812 · Cited by 1,072
Self-citationLugert, S., Basak, O., Knuckles, P., Haussler, U., Fabel, K., Götz, M., Haas, C. A., Kempermann, G., Taylor, V., & Giachino, C. (2010) · Cell stem cell · doi:10.1016/j.stem.2010.03.017 · Cited by 704
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Metadata
- Authors
- Steiner, B., Klempin, F., Wang, L., Kott, M., Kettenmann, H., & Kempermann, G.
- Venue
- Glia
- Publisher
- Wiley
- Published
- 2006-09-06
- Volume
- 54
- Issue
- 8
- Pages
- 805-814
- ISSN
- 0894-1491 (ISSN-L)
- 1098-1136
- OpenAlex
- W1970330769
- Cited by
- 342
- References
- 41
- FWCI
- 5.04
- Type
- journal article
- Language
- en
- Open access
- closed
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